en Radiation Biology Radiation Biology گزارش کوتاه Short Report <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">The aim of this study was to elucidate the efficacy of atorvastatin calcium tablets to relieve morphine tolerance in cancer pain patients. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Cancer patients were randomized into the control and observational groups. The morphine dose increment time (T2), the onset time of morphine (T1), the titration dose and pain management rate in the two groups were evaluated and compared. Adverse events such as nausea, vomiting, constipation and respiratory depression were recorded. The impact of different treatments on the life quality of patients was assessed with Karnofsky performance status (KPS) score. Liver function and hematologic toxicities of different treatment was evaluated and examined. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">The duration of T2 was significantly prolonged in the observational group (P=0.04), while the time of T1 as well as the titration dose showed no significant difference between the two groups (P>0.05). The adverse effects were slighter in the observational group (P>0.05). There was no respiratory depression case in either group. The life quality in two groups of patients showed no difference (P>0.05). Liver function and hematologic toxicitie results indicated that the combined treatment showed no extra damage to liver function and had no severe haematologic toxicity compared with the control. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">The combined treatment of atorvastatin calcium tablets and morphine effectively prolonged the time between morphine dose increments, alleviating the morphine tolerance with high safety in cancer pain patients, which may provide clues for morphine tolerance treatment in cancer pain management.</span></span></span></span></span></span></span></span></span></div> Morphine, Drug tolerance, atorvastatin calcium, cancer pain. 505 508 http://ijrr.com/browse.php?a_code=A-10-1-1201&slc_lang=en&sid=1 LF. Quan 7900319475328460027845 7900319475328460027845 No Department of Oncology, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China J. Fan fanjuan_edu@hotmail.com 7900319475328460027846 7900319475328460027846 Yes Department of Oncology, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China