en Radiation Biology Radiation Biology گزارش کوتاه Short Report <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">This study investigates the efficacy of sonodynamic and low-dose radiation with methylene blue and gold nanoparticles coated with apigenin sonosensitizer on breast cancer cells. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Method and Materials: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">HR-TEM, UV-visible, zeta-potential, FTIR, and DLS were used to confirm the synthesized gold nanoparticles coated with apigenin. The concentration of gold nanoparticles coated with apigenin and methylene blue was calculated, and then ultrasound and 2 Gy x-rays were used to irradiate them. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">The results showed that sonodynamic therapy in combination with radiation at a concentration of 8 &micro;g/ml nanoparticles and 0.4 &micro;mol methylene blue had a significant effect on cell death (0.26&plusmn; 0.02). </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">This study highlights the potential of sonodynamic therapy as a non-ionizing and non-invasive treatment, as well as the possibility of eliminating the side effects of cancer treatment by using green nanoparticles rather than chemical sensitizers.</span></span></span></span></span></span></span></span></span></div> Sonodynamic therapy, radiation, gold nanoparticles, Apigenin, methylene blue. 515 519 http://ijrr.com/browse.php?a_code=A-10-1-1203&slc_lang=en&sid=1 A. Neshastehriz 7900319475328460027851 7900319475328460027851 No Radiation Biology Research center, Iran University of Medical Sciences (IUMS), Tehran, Iran Z. Hormozi-Moghaddam Hormozimoghadam.z@iums.ac.ir 7900319475328460027852 7900319475328460027852 Yes Department of Radiation Sciences, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran S.M. Amini Amini.sm@iums.ac.ir 7900319475328460027853 7900319475328460027853 No Department of Radiation Sciences, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran S.M. Taheri 7900319475328460027854 7900319475328460027854 No Radiation Biology Research center, Iran University of Medical Sciences (IUMS), Tehran, Iran Z. Abedi Kichi 7900319475328460027855 7900319475328460027855 No Institute for cardiovascular prevention (IPEK), Ludwig-Maximilians University Munich, Germany