en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">The aim of this study was to explore the relationship between peri-coronary adipose tissue volume (V-PCAT), as assessed via coronary artery CT angiography (CCTA), and the presence and severity of coronary artery disease (CAD). </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">A retrospective analysis was conducted on 160 individuals with suspected CAD who underwent CCTA from June 2020 to December 2021. Quantification of both epicardial adipose tissue volume (V-EAT) and V-PCAT was performed. Clinical data, lipid metrics, and differences in adipose tissue volume between CAD and non-CAD groups were assessed. Variables influencing CAD were analyzed using univariate and multivariate logistic regression. The diagnostic accuracy of adipose tissue volume in predicting CAD was determined through receiver operating characteristic curves. The association between adipose tissue volume and coronary artery stenosis severity was investigated. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">The analysis included 100 patients with CAD and 60 without CAD. V-EAT and V-PCAT were notably higher in the CAD group than the without CAD group. After adjustments for confounding factors, V-EAT and V-PCAT showed a positive association with CAD. The area under the curve of V-PCAT was 0.875. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusions: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">V-PCAT, measured via CCTA was substantial associated with CAD while serving as an independent risk determinant. Additionally,&nbsp;&nbsp; V-PCAT, notably correlated with the severity of coronary artery stenosis.</span></span></span></span></span></span></span></span></span></div> Coronary artery perivascular adipose tissue volume, Coronary artery CT angiography, CAD, Coronary artery stenosis. 657 662 http://ijrr.com/browse.php?a_code=A-10-1-1222&slc_lang=en&sid=1 S.S. Yuan 7900319475328460027961 7900319475328460027961 Yes Department of Radiology, Shangyu People's Hospital of Shaoxing, Shaoxing, Zhejiang 312300, China Q. Yuan 7900319475328460027962 7900319475328460027962 No Department of Radiology, Shangyu People's Hospital of Shaoxing, Shaoxing, Zhejiang 312300, China F.Y. Xing 7900319475328460027963 7900319475328460027963 No Department of Radiology, Shangyu People's Hospital of Shaoxing, Shaoxing, Zhejiang 312300, China Y.Q. Wang wangyilan1225@163.com 7900319475328460027964 7900319475328460027964 No Department of Radiology, Shangyu People's Hospital of Shaoxing, Shaoxing, Zhejiang 312300, China