en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Chronic oxidative stress is hypothesized to precede radiation-induced brain injury in irradiated brains. This study investigated the antioxidant activity and radioprotective effects of Vitis vinifera L. seed in Wistar rats following fractionated whole-brain irradiation. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Seventy-two young adult male Wistar rats were randomly selected and divided into three equal groups. Group A was the control group, while Groups B and C received a total dose of 40 Gy of </span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="language:en-US">⁶⁰</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Co gamma radiation to the head. The radiation dose was fractionated at 5 Gy per exposure. In addition, group C rats were orally administered 100 mg/kg/day of Vitis vinifera L. seeds starting from one week before exposure and lasting until the time of sacrifice. At weeks 1, 2, 3, and 4 post-irradiations, the average brain weights, total brain protein concentration, and superoxide dismutase activity of the rat brains were determined. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">The study recorded significant reductions in the average brain weights, total brain protein concentration, and brain superoxide dismutase activity in group B rats when compared to groups A and C (P < 0.05). However, the study found that group C rats had a higher total brain protein concentration (P > 0.05), correlative average brain weight (P > 0.05), and a significant increase in brain superoxide dismutase activity (P < 0.05) when compared with group A rats. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusions: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Vitis vinifera L. seed has antioxidant and radioprotective effects on irradiated rat brains.</span></span></span></span></span></span></span></span></span></div> antioxidants, oxidative stress, radiation, superoxide dismutase, Vitis. 663 668 http://ijrr.com/browse.php?a_code=A-10-1-1223&slc_lang=en&sid=1 A.A. Abe saintcodded@gmail.com 7900319475328460027965 7900319475328460027965 Yes Department of Physics and Engineering Physics, Obafemi Awolowo University, Nigeria O.A. Ayannuga 7900319475328460027966 7900319475328460027966 No Department of Anatomy and Cell Biology, Obafemi Awolowo University, Nigeria F.A. Balogun 7900319475328460027967 7900319475328460027967 No Department of Physics and Engineering Physics, Obafemi Awolowo University, Nigeria