en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Following surgery, lung infections are a frequent side effect that colorectal cancer patients experience and can be fatal. A meta-analysis was carried out to elucidate the risk variables for postoperative lung infection in patients with colorectal cancer. This information can help direct treatment and prevention strategies in clinical practice. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods:</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US"> Searches in PubMed, PMC, and other databases yielded clinical trials pertaining to aspects that increase the likelihood of postoperative lung infection in colorectal cancer patients. According to the abstract, key words, etc., literature screening. The Rev Man 5.4.1 was utilised to carry out a meta-analysis of the publications that fulfilled the grade requirements. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Finally, 10 studies were included, including 5165 patients with colorectal cancer, and the differences between infected and non-infected patients were analyzed. The results indicate that there were no risk factors for postoperative pulmonary infection in colorectal cancer patients based on age (95%CI (-23.16, 15.39), P = 0.69), TNM grade (95%CI (-0.06, 0.11), P = 0.56), operation time (95%CI (-0.02, 0.27), I2=89%, P=0.09), or COPD (95%CI (-0.01, 0.61), I2=98%, P=0.06). Factors that increase the likelihood of postoperative pulmonary infection in colorectal cancer patients include gender (95%CI [0.01,0.09]; P = 0.01), body mass index (95%CI [0.00,0.22]; P=0.04), surgical approach (95%CI [0.01,0.42]; P = 0.04), and a history of smoking (95%CI [0.06,0.34]; P=0.006). </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Clinical treatment and rehabilitation for colorectal cancer patients should take into account the multiple risk factors for lung infection following surgery, including gender, body mass index (BMI), surgical technique, and smoking history.</span></span></span></span></span></span></span></span></span></div> Colorectal cancer, risk factors, postoperative pulmonary infection, meta-analysis, radiotherapy. 719 725 http://ijrr.com/browse.php?a_code=A-10-1-1231&slc_lang=en&sid=1 Z. Xiaoshuai 7900319475328460028066 7900319475328460028066 No Ningbo Yinzhou District Second Hospital, Ningbo, China Z. Zhendong 7900319475328460028067 7900319475328460028067 No Ningbo Second Hospital, Ningbo, China S. Xiaoke sxk841201@163.com 7900319475328460028068 7900319475328460028068 Yes Cixi People's Hospital Medical and Health Group (Cixi People's Hospital), Cixi, China