en Radiation Biology Radiation Biology مطالعه موردي Case Report <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Here, we report a non-smoker, a 38-year-old male patient with High-Grade Glioma (HGG). The patient with the initial signs of swelling of his left arm and leg and dizziness without any nausea and vomiting and other neurological symptoms was referred to a neurosurgeon and then underwent Magnetic Resonance Imaging (MRI). The MRI showed the enhancement in T1 and T2 and flair. The radiologist suggested a tumor probably, HGG. The patient was treated with external beam radiation therapy (EBRT) with a total dose of 54 Gy in 27 fractions combined with the Temozolomide (TMZ) regime (75 mg/m</span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="language:en-US">²</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">/day). The patient was prescribed 140 mg TMZ per day. By mistake, the patient received a 280 mg drug dose daily for 29 days. Due to this miscalculation, he was hospitalized and recovered for one month. After 30 months he is alive and is free of progression according to the MRI.</span></span></span></span></span></span></span></span></span></div> Medication errors, Temozolomide, Chemotherapy Overdose, High-Grade Glioma. 807 809 http://ijrr.com/browse.php?a_code=A-10-1-1241&slc_lang=en&sid=1 A. Ebrahimi 7900319475328460028131 7900319475328460028131 No The Advocate Center for Clinical Research, Ayatollah Yasrebi Hospital, Kashan, Iran D. Khoramian daryoushkhoramian@gmail.com 7900319475328460028132 7900319475328460028132 Yes Department of Medical Physics, The Advocate Center for Clinical Research, Ayatollah Yasrebi Hospital, Kashan, Iran N. Tabatabaei 7900319475328460028133 7900319475328460028133 No The Advocate Center for Clinical Research, Ayatollah Yasrebi Hospital, Kashan, Iran S. Sarvizadeh 7900319475328460028134 7900319475328460028134 No Department of Medical Physics, The Advocate Center for Clinical Research, Ayatollah Yasrebi Hospital, Kashan, Iran