en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">To explore the diffusion characteristics of the hippocampus injury (HI) in children during the complex acute febrile seizure (CAFS) through multiple b value (1000-2000 s/mm</span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="language:en-US">²</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">) of diffusion-weighted imaging (DWI). </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">This prospective observational study enrolled children with HI during CAFS, and nasopharyngeal and sinus disease (NSD). The multiple b value from DWI of the hippocampus were scanned. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">A total of 41 children were included, with 21 of them had HI during CAFS, while the other 20 children were NSD. There was significant difference in apparent diffusion coefficient (ADC) values of the left and right hippocampus between children with HI during CAFS and NSD (r < 0.05). The corresponding ADC graphs were relatively clear at b = 1000 s/mm2 and 1200 s/mm</span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="language:en-US">²</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Hippocampal DWI scans at b = 1000 s/mm</span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="language:en-US">²</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US"> and 1200 s/mm</span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="language:en-US">²</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US"> might be recommended clinical b value point for diffusion characterization of HI.</span></span></span></span></span></span></span></span></span></div> Febrile seizures, hippocampus injury, diffusion characteristics, b-value, DWI, ADC map. 971 975 http://ijrr.com/browse.php?a_code=A-10-1-1265&slc_lang=en&sid=1 X. He 7900319475328460028642 7900319475328460028642 No Department of Radiology, Hainan Women & Children's Medical Center, Haikou, Hainan 570206, China Y. Wei 7900319475328460028643 7900319475328460028643 No Department of Radiology, Hainan Women & Children's Medical Center, Haikou, Hainan 570206, China Sh. Wu 7900319475328460028644 7900319475328460028644 No Department of Radiology, Hainan Women & Children's Medical Center, Haikou, Hainan 570206, China F. Huang 7900319475328460028645 7900319475328460028645 No Department of Radiology, Hainan Women & Children's Medical Center, Haikou, Hainan 570206, China K. Zhang 15595840997@163.com 7900319475328460028646 7900319475328460028646 Yes Department of Radiology, Hainan Women & Children's Medical Center, Haikou, Hainan 570206, China