en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">A custom-built head phantom has the potential as a dosimetric phantom in brain radiotherapy. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Materials and Methods</span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-GB">:</span></span></span></span></span> <span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">Computed tomography (CT) was used to scan the phantom with CT data imported to treatment planning system (TPS) for dose computation. The dose prescription was pre-determined to deliver 300 cGy per fraction to the isocenter of the beam. 6 MV photon with parallel-opposed technique was used in this work. Absorbed dose computed in planning target volume (PTV) and organ at risks (OARs) were computed, and comparison was made with Monte Carlo (MC) Geant4 Application for Tomographic Emission (GATE). </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Results: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">The result demonstrates a close proximity of computed dose for TPS and GATE with a 1.6 % discrepancy for the PTV, with less than 1 % statistical uncertainty for GATE. The dose measured by TPS for most of the target of interest was in close proximity with the dose measured in MC. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Conclusion: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">This study revealed the potential of MC GATE simulation in the dosimetric evaluation and verification of the treatment planning.</span></span></span></span></span></span></span></span></span></span></div> Dosimetry, brain radiotherapy, Monte Carlo simulation, treatment-planning system, GATE. 13 20 http://ijrr.com/browse.php?a_code=A-10-1-1286&slc_lang=en&sid=1 S.H. Zuber hajarzuber@ukm.edu.my 7900319475328460029946 7900319475328460029946 Yes Centre for Diagnostic, Therapeutic and Investigative Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia M.F.R. Abdul Hadi 7900319475328460029947 7900319475328460029947 No School of Physics, Universiti Sains Malaysia, Penang, Malaysia N.A.A. Hashikin 7900319475328460029948 7900319475328460029948 No School of Physics, Universiti Sains Malaysia, Penang, Malaysia D.O. Samson 7900319475328460029949 7900319475328460029949 No Department of Physics, Faculty of Science, University of Abuja, Abuja, Malaysia N.H. Ishak 7900319475328460029950 7900319475328460029950 No Advanced Medical & Dental Institute, Universiti Sains Malaysia, Penang, Malaysia N.A. Raof 7900319475328460029951 7900319475328460029951 No Advanced Medical & Dental Institute, Universiti Sains Malaysia, Penang, Malaysia M.Z. Abdul Aziz 7900319475328460029952 7900319475328460029952 No Advanced Medical & Dental Institute, Universiti Sains Malaysia, Penang, Malaysia M.F.M. Yusof 7900319475328460029953 7900319475328460029953 No Faculty of Health and Life Sciences, Management & Science University, Selangor, Malaysia N.A. Rabaiee 7900319475328460029954 7900319475328460029954 No Department of Radiology, Kulliyyah of Medicine, International Islamic University Malaysia, Gombak, Malaysia