International Journal of Radiation Research

en Investigation of the reproducibility of bladder dose- volume histogram (DVH) in prostate tomotherapy using the center of mass of the bladder in daily megavoltage computed tomography (MVCT) images Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: The DVH is the most used radiotherapy formulation. DVH plays a fundamental role in determining dose constraints and side effects. Volume also plays the main role in calculating DVH. In prostate treatment, there is no comprehensive consensus on determining the association between bladder volume (BV) and side effects. Our aim is to investigate the reproducibility of bladder DVH (DVHB). D50%BV (dose received by 50% of BV) is used to analysis DVHB. Materials and Methods: We contoured the bladder of 467 daily MVCT images of fifteen prostate cancer patients who underwent tomotherapy. Using R software 4.2.3, the correlation between the bladder center of mass (XCM, YCM, ZCM), BV with D50%BV were modeled by the mixed model. Two prediction models were presented for D50%BV, the first model was based on BV and (XCM, YCM, ZCM), the second model was based on BV. Results: Statistical analyses revealed that independent factors YCM, ZCM, and BV have a significant influence on the response variable D50%BV. According to mixed model, YCM has a positive correlation with D50%BV, while ZCM or BV has a negative correlation. XCM does not significantly affect D50%BV. Akaike Information Criterion (AIC) index indicated that first model has a higher goodness of fit than second one. Conclusion: Our findings demonstrate that bladder location also affects D50%BV, in addition to BV. It can be concluded that DVHB is not always repeatable as a scientific claim.</div> Prostate cancer, tomotherapy, DVH (dose volume histogram), bladder, reproducibility, mixed model. 111 120 http://ijrr.com/browse.php?a_code=A-10-1-1299&slc_lang=en&sid=1 F. Goli-Ahmadabad 7900319475328460029479 7900319475328460029479 No Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran S.R. Mahdavi srmahdavi@hotmail.com 7900319475328460029480 7900319475328460029480 Yes Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran A. Nikoofar 7900319475328460029481 7900319475328460029481 No Department of Radiation Oncology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran A. Zare-Sadeghi 7900319475328460029482 7900319475328460029482 No Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran H. Vazirinasab 7900319475328460029483 7900319475328460029483 No Department of Epidemiology and Biostatistics, School of Public Health, Kerman University of Medical Sciences, Kerman, Iran S. Bagherzadeh 7900319475328460029484 7900319475328460029484 No Cellular and Molecular Biology Research Center, Larestan University of Medical Sciences, Larestan, Iran G. Esmaili 7900319475328460029485 7900319475328460029485 No Department of Radiotherapy, Pars Hospital, Tehran, Iran N. Hasani N. Hasani 7900319475328460029486 7900319475328460029486 No Department of Radiotherapy, Pars Hospital, Tehran, Iran