en Radiation Biology Radiation Biology تحقيق بديع Original Research <p><strong>Backgrounds: </strong>Bleomycin (BLM) has been labeled with radioisotopes and widely used in therapy and diagnosis. In this study BLM was labeled with [⁶²Zn] zinc chloride for oncologic PET studies. </p><p><strong>Materials and methods: </strong>The complex was obtained at the pH=2 in normal saline at 90 ° C in 60 min. Radio-TLC showed an overall radiochemical yield of 95-97% (radiochemical purity > 97%). Stability of complex was checked <i>in vitro</i> in mice and human plasma/urine. </p><p><strong>Results: </strong>Preliminary <i>in vivo</i> studies performed to determine complex stability and distribution of [⁶²Zn] BLM in normal and fibrosarcoma-bearing mice. [⁶²Zn] BLM accumulated significantly in induced fibrosarcoma tumors in mice according to bio-distribution/imaging studies. </p><p><strong>Conclusion: </strong>[⁶²Zn] BLM can be used in PET oncology studies due to its suitable physico-chemical properties as a diagnostic complex <i>in vitro</i> and <i>in vivo</i>. Further studies should be performed for evaluation of the complex behavior in higher animals. <i>Iran </i><i>. J. Radiat. Res., 2003 1(1): 37 - 44. </i></p> PET, pharmacokinetic, biodistribution, zinc-62, bleomycin 37 44 http://ijrr.com/browse.php?a_code=A-10-1-6&slc_lang=en&sid=1 A.R. Jalilian ajalilian@nrcam.org 7900319475328460013 7900319475328460013 Yes B. Fateh 7900319475328460014 7900319475328460014 No M. Ghergherehchi 7900319475328460015 7900319475328460015 No A. Karimian 7900319475328460016 7900319475328460016 No M. Matlloobi 7900319475328460017 7900319475328460017 No