other Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">The comparative analysis of minimally invasive radical hysterectomy (MIRH) and open radical hysterectomy (ORH) in cervical cancer (CC) patients undergoing primary chemoradiation has yielded divergent and contentious study conclusions. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Materials and Methods: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">A comprehensive literature search was conducted across PubMed, Web of Science core database, Nature, Science Direct, and others, covering the period from January 2007 to the present. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Results: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">Ten relevant articles were identified, encompassing 4,148 CC patients who underwent radical hysterectomy, with 1,949 (47.0%) undergoing MIRH and 2,199 (53.0%) undergoing ORH. Among these patients, 767 experienced recurrence, and 223 succumbed to the disease. The analysis revealed a slightly higher recurrence rate in patients who underwent MIRH versus ORH [OR=1.25, 95% CI=1.02~1.54, Z=2.16, P=0.03], demonstrating statistical significance (P<0.05). However, the mortality rate in MIRH patients was marginally superior to in ORH patients [OR=1.02, 95% CI=0.76 ~ 1.37, Z=0.11, P=0.91] (P>0.05). MIRH was associated with a slightly lower complication rate versus ORH [OR=0.40, 95% CI=0.28 ~ 0.57, Z=5.02, P<0.00001], and a significantly reduced incidence of perioperative blood transfusions [OR=0.19, 95% CI=0.05 ~ 0.58, Z=4.18, P<0.0001]. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Conclusion: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">The findings suggest that ORH is linked to lower recurrence and mortality rates versus minimally invasive surgery, establishing its potential advantage in the treatment of CC.</span></span></span></span></span></span></span></span></span></span></div> Minimally invasive radical hysterectomy (MIRH), cervical cancer, meta-analysis, primary chemo-radiotherapy. 185 191 http://ijrr.com/browse.php?a_code=A-10-1-1309&slc_lang=other&sid=1 J. Pan 7900319475328460029604 7900319475328460029604 No Department of Gynecology, Huzhou Maternity & Child Health Care Hospital, Zhejiang, China H. Hang 7900319475328460029605 7900319475328460029605 No Department of Gynecology, Huzhou Maternity & Child Health Care Hospital, Zhejiang, China Q. Hu likeyou022003@163.com 7900319475328460029606 7900319475328460029606 Yes Department of Gynecology, Huzhou Maternity & Child Health Care Hospital, Zhejiang, China