en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">To investigate the effects of laparoscopic ultrasound (LUS)-guided microwave ablation (MWA) combined with surgical resection on liver function and immune function of primary liver cancer (PLC) patients. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Clinical data of 100 patients with PLC after surgery in our hospital from January 2021 to December 2023 were retrospectively analyzed, and divided into laparoscopic hepatectomy (LH group) and laparoscopic ultrasound-guided microwave ablation combined with laparoscopic hepatectomy (LMWA+LH group). Clinical indicators, clinical efficacy, liver function, tumor markers, immune function, incidence of complications, postoperative overall survival rate along with tumor free survival rate between groups were compared. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Compared with the LH group, the intraoperative blood loss and postoperative hospital stay was decreased in the LMWA+LH group (P<0.05). Total effective rate of the LMWA+LH group was 90.00%, higher than the 70.00% in LH group (P<0.05). After therapy, reduction in aspartate alanine aminotransferase (ALT), aminotransferase (AST), total bilirubin (TBIL), and the elevation in albumin (ALB) in the LMWA+LH group were more obvious (P<0.05). The LMWA+LH group showed more obvious elevation in CD4+ and CD4+/CD8+ levels and reduction in CD8+ level relative to the LH group (P<0.05). The complication incidence showed no statistical difference between groups (P>0.05). Postoperative survival and tumor free survival rates in the LMWA+LH group were higher than LH group (P<0.05). </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Laparoscopic ultrasound-guided microwave ablation combined with surgical resection promotes the postoperative recovery, improves liver function and immune function and improves patient survival rate, which might provide guidance for clinical practice.</span></span></span></span></span></span></span></span></span></div> IMRT, Primary liver cancer, ultrasonography, microwave ablation, hepatectomy, liver function, immune function. 297 305 http://ijrr.com/browse.php?a_code=A-10-1-1328&slc_lang=en&sid=1 L. Zhu 7900319475328460031044 7900319475328460031044 No Department of Ultrasonic Medicine, Yichun City People's Hospital, Yichun 336000, Jiangxi, China L. Chen LICHEN7006@163.com 7900319475328460031045 7900319475328460031045 Yes Department of Ultrasonic Medicine, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China C. Du 7900319475328460031046 7900319475328460031046 No Department of Ultrasonic Medicine, Yichun City People's Hospital, Yichun 336000, Jiangxi, China N. Tao 7900319475328460031047 7900319475328460031047 No Department of Ultrasonic Medicine, Yichun City People's Hospital, Yichun 336000, Jiangxi, China J. Pan 7900319475328460031048 7900319475328460031048 No Department of Ultrasonic Medicine, Yichun City People's Hospital, Yichun 336000, Jiangxi, China