en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">To analyze the sensitivity and specificity of magnetic resonance imaging (MRI) in diagnosing cartilage invasion in laryngeal neoplasms. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">A comprehensive search for relevant studies was conducted in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and the Cochrane Trials Registry, with the search period extending until September 1, 2024.Sensitivity, specificity, and diagnostic likelihood ratio (DLR) were combined. Symmetrical Receiver Operating Characteristic (SROC) curves and Fagan nomograms were plotted. Meta-regression and subgroup analyses were performed to identify heterogeneity sources. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">A total of seven studies involving 418 participants were included. MRI demonstrated a sensitivity of 0.93 [95% CI: 0.89&ndash;0.96, I&sup2;=0.00] and a specificity of 0.88 [95% CI: 0.81&ndash;0.92, I&sup2;=70.36] for detecting cartilage invasion. The negative diagnostic likelihood ratio (DLR-) was 0.08 with a 95% confidence interval of 0.05 to 0.13. The Area Under Curve(AUC) of the SROC curve was 0.95 with a 95% confidence interval of 0.85 to 0.99. Leave-one-out sensitivity analysis validated the robustness of the results concerning heterogeneity, as subgroup analysis did not mitigate it. Deek&#39;s funnel plot showed a symmetrical distribution of studies around the regression line, indicating no significant publication bias (t=0.92, P=0.40). </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">MRI provides a reliable diagnostic performance for cartilage invasion in Laryngeal Neoplasms.</span></span></span></span></span></span></span></span></span></div> IMRT, Laryngeal neoplasms, cartilage invasion, magnetic resonance imaging, meta-analysis. 455 460 http://ijrr.com/browse.php?a_code=A-10-1-1350&slc_lang=en&sid=1 Z.D. Wang 7900319475328460030843 7900319475328460030843 No Department of Otolaryngology, The Air Force Hospital of the Northern Theater Command of the Chinese People's Liberation Army, Shenyang, Liaoning, China Y. Zhan 7900319475328460030844 7900319475328460030844 No Department of Otolaryngology, The Air Force Hospital of the Northern Theater Command of the Chinese People's Liberation Army, Shenyang, Liaoning, China H. Cao 7900319475328460030845 7900319475328460030845 No Department of Otolaryngology, The Air Force Hospital of the Northern Theater Command of the Chinese People's Liberation Army, Shenyang, Liaoning, China X.D. Shan 7900319475328460030846 7900319475328460030846 No Department of Otolaryngology, The Air Force Hospital of the Northern Theater Command of the Chinese People's Liberation Army, Shenyang, Liaoning, China X.H. Tai 13324042800@163.com 7900319475328460030847 7900319475328460030847 Yes Department of Otolaryngology, The Air Force Hospital of the Northern Theater Command of the Chinese People's Liberation Army, Shenyang, Liaoning, China