en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background:</span></span></span></span></span> <span lang="en-US" style="language:en-US">To assess the effectiveness and safety of combining ultrasound-guided interventional therapy with radiotherapy (RT) in treating Hepatocellular Carcinoma (HCC). </span><span lang="en-US" style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods: </span></span></span></span></span><span lang="en-US" style="language:en-US">Literature was searched in PubMed, Coghlan&#39;s database and Web of Science (WOS) up to November 2024 without language restriction. Outcome indicators included complete response (CR), partial response (PR), stable disease (SD), disease progression (PD), 1-year survival rate, and adverse events (AEs). The Cochrane Collaboration tool was utilized to evaluate the risk of bias in the included studies. Statistical analysis was performed based on revman software, and P<0.05 was considered statistically significant. </span><span lang="en-US" style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span><span lang="en-US" style="language:en-US">Five studies were included in the analysis, and the overall quality of the studies was high. The combination therapy group demonstrated statistically significant differences compared to the control group in PR (OR=2.14, 95% CI: 1.32&ndash;3.48, P=0.002), PD (OR=0.45, 95% CI: 0.27&ndash;0.76, P=0.003), and AEs (OR=0.54, 95% CI: 0.35&ndash;0.82, P=0.004). No statistically significant differences were observed between the two groups in terms of CR (OR=1.31, 95% CI: 0.24&ndash;7.01, P=0.760), SD (OR=0.88, 95% CI: 0.50&ndash;1.55, P=0.670), and one-year survival rate (OR=1.62, 95% CI: 0.85&ndash;3.09, P=0.140). </span><span lang="en-US" style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion: </span></span></span></span></span><span lang="en-US" style="language:en-US">Ultrasound-guided interventional therapy combined with RT demonstrates certain clinical advantages in the treatment of HCC, particularly in improving PR, reducing PD, and managing AEs. Additional studies are required to confirm its long-term effectiveness and safety.</span></span></span></span></span></span></span></div> Hepatocellular carcinoma, ultrasound-guided, radiotherapy, synergistic treatment, meta-analysis. 627 633 http://ijrr.com/browse.php?a_code=A-10-1-1377&slc_lang=en&sid=1 W. Zhao 7900319475328460031538 7900319475328460031538 No Department of Ultrasound, Minda Hospital of Hubei Minzu University, Enshi, Hubei, China 445000 Y. Liu 7900319475328460031539 7900319475328460031539 No Department of Ultrasound, Minda Hospital of Hubei Minzu University, Enshi, Hubei, China 445000 X. Li 7900319475328460031540 7900319475328460031540 No Department of Ultrasound, Minda Hospital of Hubei Minzu University, Enshi, Hubei, China 445000 G. Chen 819136262@qq.com 7900319475328460031541 7900319475328460031541 Yes Department of Ultrasound, Minda Hospital of Hubei Minzu University, Enshi, Hubei, China 445000