en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background:</span></span></span></span></span></span> <span lang="en-US" style="language:en-US">It aimed to compare the efficacy of digital mammography and magnetic resonance imaging (MRI) used alone and in combination in the diagnosis of ductal carcinoma in situ (DCIS). </span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Material and Methods: </span></span></span></span></span></span><span lang="en-US" style="language:en-US">78 patients with pathologically confirmed DCIS were enrolled in this retrospective study. All patients underwent digital mammography and MRI. The imaging results were graded using the Breast Imaging Reporting and Data System (BI-RADS), and the diagnostic sensitivity (Sen), specificity (Spe), and accuracy (Acc) of the two methods, both individually and in combination, were calculated. </span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="language:en-US">imaging findings were classified as highly suspicious (BI-RADS grade 4 and above) or not highly suspicious (BI-RADS grade 3 and below). The Sen, Spe, and Acc of digital mammography in the diagnosis of DCIS were 68.97%, 60%, and 66.67%, respectively. The Sen, Spe, and Acc of MRI were 77.5%, 70%, and 75.64%, respectively. When the two techniques were combined, the Sen was increased to 87.93%, the Spe was 75%, and the Acc was 84.62%. There were visible distinctions in Sen and Acc between the combined use and single mammography detection (P<0.05). </span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion: </span></span></span></span></span></span><span lang="en-US" style="language:en-US">the combined use of digital mammography and MRI shows high Sen and Acc in the diagnosis of DCIS, which is more effective than single method. This article supports the use of multimodal diagnostic strategies in clinical practice to improve the diagnostic efficiency of DCIS.</span></span></span></span></span></span></span></div> Ductal carcinoma in situ, mammography, magnetic resonance imaging, sensitivity, specificity, diagnostic accuracy. 707 713 http://ijrr.com/browse.php?a_code=A-10-1-1387&slc_lang=en&sid=1 R. Lin Linruiying@mjc-edu.cn 7900319475328460031788 7900319475328460031788 Yes Department of Radiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou 350001,Fujian Province, China G. Xiao 7900319475328460031789 7900319475328460031789 No Department of Radiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou 350001,Fujian Province, China W. Xiu 7900319475328460031790 7900319475328460031790 No Department of Radiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou 350001,Fujian Province, China S. Cai 7900319475328460031791 7900319475328460031791 No Department of Radiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou 350001,Fujian Province, China