en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background:</span></span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Radiation therapy is one of the most important methods of breast cancer treatment that can cause complications that affect the patient&#39;s quality of life. The aim of this study was a dosimetric comparison of skin complications after hypofractionated radiotherapy (HFRT) and conventional fractionated radiotherapy (CFRT) in breast cancer patients. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">In this cross-sectional study between November 2021 and July 2022, 55 patients were reviewed. Thirty-six patients received CFRT (50Gy in 25 fractions), and 19 patients received HFRT (42. 5Gy in 16 fractions). Skin complications during treatment and 40 days after radiotherapy were evaluated and compared for these two procedures. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">The incidence of grade 1, 2, and 3 skin complications up to 40 days after CFRT was 100%, 88.8%, and 22.2%, respectively; also, in HFRT, the incidence of grade 1, 2, and 3 skin complications was 89.4%, 36.8%, and zero, respectively. The results show that the incidence of skin complications is significantly higher with the CFRT than with the HFRT (P<0.05). </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">In this clinical study, both in terms of complications and dosimetry, it was shown that patients undergoing radiation therapy with the hypofractionation technique had fewer skin complications compared to those treated with the conventional technique.</span></span></span></span></span></span></span></span></span></div> Breast cancer, radiotherapy, dermatitis. 715 720 http://ijrr.com/browse.php?a_code=A-10-1-1388&slc_lang=en&sid=1 M.A. Boroumand 7900319475328460031818 7900319475328460031818 No Clinical Oncology Department, Shahid Sadoughi University of Medical Sciences, Yazd, Iran R. Azmoonfar 7900319475328460031819 7900319475328460031819 No Department of Radiology, School of Allied Medical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran F. MadadiZadeh 7900319475328460031820 7900319475328460031820 No Biostatistics and Epidemiology Departments, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran K. Saber korosh.iut@gmail.com 7900319475328460031821 7900319475328460031821 Yes Department of Medical Physics, School of Medical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran N. Hamzian hamzian.nima@gmail.com 7900319475328460031822 7900319475328460031822 No Medical Physics Department, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran