en Radiation Biology Radiation Biology گزارش کوتاه Short Report <span style="font-weight: bold">Background:</span> The 153Sm-[tris(1,10-phenanthroline) Samarium(III)]complex (¹⁵³Sm-PL₃) was prepared in view of development of targeting therapeutic compounds for malignancies, and interesting in-vitro anti-tumor activities of lanthanide phenanthroline complexes,. <span style="font-weight: bold">Materials and Methods:</span> Sm-153 chloride was obtained by thermal neutron flux (4 × 10¹³ n.cm^-2.s^-1) of enriched ¹⁵²Sm₂O₃ sample, dissolved in acidic media. The labeling was performed in ethanol in 24h, controlled by ITLC (1.0mM DTPA, pH.5, as mobile phase). The partition coefficient for the labeled compound was also determined. <span style="font-weight: bold">Results: </span>A radiochemical yield of more than 95% was obtained. Radiochemical purity of 96% was obtained using ITLC with specific activity of about 27.75 GBq/mg. The radio-labeled complex was stable in aqueous solution at least 24 hours and no significant amount of free ¹⁵³Sm was released from the complex. The partition coefficient for the labeled compound was determined (log P. 3.4). The complex was stable in final formulation for 66h. The biological evaluation of the compound is under investigation. <span style="font-weight: bold">Conclusion:</span> The radiolabeled compound used in this study was a very inexpensive and useful agent for the use as a therapeutic compound. <span style="font-weight: bold">Iran. J. Radiat. Res., 2012 10(1): 59-62 </span> Samarium-153, 1, 10-phenanthroline, radiolabeling, quality control 59 62 http://ijrr.com/browse.php?a_code=A-10-1-421&slc_lang=en&sid=1 Z. Naseri 790031947532846002718 790031947532846002718 No A. Hakimi 790031947532846002719 790031947532846002719 No S. Shirvani-Arani 790031947532846002720 790031947532846002720 No A.R. Jalilian ajalili@aeoi.org.ir 790031947532846002721 790031947532846002721 Yes A. Bahrami-Samani 790031947532846002722 790031947532846002722 No M. Nemati Kharat 790031947532846002723 790031947532846002723 No M. Ghannadi-Maragheh 790031947532846002724 790031947532846002724 No