@article{ author = {M.Rezvani, and G.A.Ross, and K.Lamb, and J.H.Wilkinson,}, title = {Effects of Pentoxifylline on the healing of irradiated wounds in pig skin}, abstract ={Background: This study was designed to investigate the efficacy of Pentoxifylline (PTX) in the treatment of irradiated wounds. Materials and Methods: Ten female pigs of the Large White strain were used in these investigations. Six skin fields, 4 * 4 cm and separated from each other by 4 cm, were marked out on each flank and those on left flank were irradiated with 18Gy single dose of 250 kV X-rays. The animals were then randomly allocated to one of three groups. Ten weeks after irradiation a 2 * 2 cm surgical wound was produced, by removing the skin up to facia level, at the centre of the original skin fields. This was done on both irradiated (left flank) and unirradiated control (right flank) fields. Two groups of animals were treated by daily oral gavaging, with 13.3mg/kg/day PTX dissolved in 10 ml water while a group of control animals received only 10 ml water by oral gavage as placebo. PTX treatment started either two weeks prior to wounding or at the day of wounding. The progression of the healing of excision wounds were evaluated periodically by assessment of wound contraction. Results and Conclusion: Overall, irradiated wounds healed much slower than unirradiated wounds. While PTX treatment had no effect on the healing rate of unirradiated wounds it appeared that treating the animals with PTX delayed the healing of irradiated wounds. This was true whether PTX treatment started two weeks prior to or at the time of wounding. Iran . J. Radiat. Res., 2004 2 (1): 1-7}, Keywords = {, wound healing, Pentoxifylline, pig skin}, volume = {2}, Number = {1}, pages = {1-7}, publisher = {Dr. Hossein Mozdarani}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijrr.com/article-1-35-en.html}, eprint = {http://ijrr.com/article-1-35-en.pdf}, journal = {International Journal of Radiation Research}, issn = {2322-3243}, eissn = {2345-4229}, year = {2004} } @article{ author = {K.Firouznia, and H.Ghanaati, and H.Hashemi, and N.Ahmadinezhad, and H.Soroush, and M.Shakiba,}, title = {Percutaneous laser photocoagulation of osteoid osteoma: Assessment of treatment in nine cases}, abstract ={ABSTRACT Background: Osteoid osteoma is a benign bony neoplasm and its classic treatment is surgery. In the r ecent decades percutaneous laser therapy was suggested to be replaced by surgery. In this study we have reviewed the results of the first applications of interstitial laser photocoagulation (ILP) for treatment of osteoid osteoma in Iranian patients. Materials and Methods: In this case series study, we evaluated 9 known cases of osteoid osteoma that were referred for ILP from orthopedic section of Imam Khomeini hospital during 2001 and 2002. Diagnosis was confirmed by plain X-ray, CT, isotope & MR scan. ILP was done by interventional radiologists of medical imaging center. Percutaneous ILP was performed by Nd-Yag laser, using 400-1000 joules energy (according to nidus size) and adjusting on 2 watts power. Results: The procedure was successful in all patients. We had pain relief in 24 hours. Follow up from 5 months to one year showed no recurrence. Conclusion: The procedure is a safe and effective method for patients and could be applied for proper cases.}, Keywords = {, interstitial laser photocoagulation, CT scan, bone tumors, interventional radiology}, volume = {2}, Number = {1}, pages = {9-14}, publisher = {Dr. Hossein Mozdarani}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijrr.com/article-1-42-en.html}, eprint = {http://ijrr.com/article-1-42-en.pdf}, journal = {International Journal of Radiation Research}, issn = {2322-3243}, eissn = {2345-4229}, year = {2004} } @article{ author = {S.Hosseini, and H.Mozdarani,}, title = {Induction of premature chromosome condensation (PCC) by calyculin A for biodosimetry}, abstract ={Background: Premature chromosome condensation (PCC) is a method for interphase chromosome analysis in biodosimetry. This study was performed to verify the usefulness of PCC induced by calyculin A in human peripheral blood lymphocytes (pbl) for biological dosimetry and possible construction of dose-response curve. Materials and Methods: Peripheral blood was obtained from a healthy donor and exposed to various doses (0.25–4 Gy) of γ -rays. The frequency of simple breaks and dicentrics were scored in G2/M chromosomes of Giemsa stained cells. Results: Results show that the frequency of simple chromosome breaks appears to increase linearly with dose while the frequency of dicentrics apparently increases linear-quadratically with the dose. Conclusion: Induction of chromosome condensation by calyculin A is a powerful biodisimetric method, which provides a high number of spreads for analysis. With the use of this method, it is possible to overcome problems related to low mitotic index or cell-cycle alterations in routine metaphase analysis and low fusion rate in conventional PCC technique. Iran . J. Radiat. Res., 2004 2 (1): 15-20}, Keywords = {, PCC, calyculin A, human lymphocytes}, volume = {2}, Number = {1}, pages = {15-20}, publisher = {Dr. Hossein Mozdarani}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijrr.com/article-1-36-en.html}, eprint = {http://ijrr.com/article-1-36-en.pdf}, journal = {International Journal of Radiation Research}, issn = {2322-3243}, eissn = {2345-4229}, year = {2004} } @article{ author = {S.M.J.Mortazavi, and M.Ghiassi-Nejad, and M.Bakhshi, and M.Jafari-Zadeh, and A.Kavousi, and J.Ahmadi, and A.Shareghi,}, title = {Entrance surface dose measurement on the thyroid gland in orthopantomography: The need for optimization}, abstract ={Background: The anatomic position and proven radiosensitivity of the thyroid make it an organ of concern in dental X-ray examinations. A National Radiation Protection Department (NRPD)-sponsored pilot study carried out in the Dental Radiology Department of RUMS., to assess if the radiation dose in panoramic radiographies could be reduced without significant impairment of the subjective image quality. Materials and Methods: Thermoluminescent dosimetry (TLD) is widely acknowledged to be the recommended method for measuring entrance surface doses (ESD). In this study, ESD was measured using LiF thermoluminescent dosimeters (TLD-100) on the thyroid of 40 patients who had referred to the School of Dentistry , Rafsanjan University of Medical Sciences. Patients were not exposed to any additional radiation and the radiographs were used for diagnostic purposes. TLDs were calibrated with radiation energies similar to those commonly used in orthopantomography. Results: The overall mean ESD on the thyroid in orthopantomography was 0.071 ± 0.012 mGy (ranged from 0.01 to 0.40 mGy). The mean ESD for radiographies performed with 66 kVp (20 patients) and 68 kVp (20 patients) were 0.072 ± 0.019, and 0.070 ± 0.016 respectively. No statistically significant difference was found between these means. Conclusions: The measured surface doses in our study are inconsistent with the only one already reported about the same experiment. However, due to lack of national diagnostic reference levels for orthopantomography, it is not clear whether in case of the PM 2002 CC unit used in this experiment, reducing the radiation dose to a level that still keeps a diagnostically acceptable image quality is necessary. Iran . J. Radiat. Res., 2004 2 (1): 21-26}, Keywords = {, OPG, panoramic radiography, entrance surface dose, thyroid}, volume = {2}, Number = {1}, pages = {21-26}, publisher = {Dr. Hossein Mozdarani}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijrr.com/article-1-37-en.html}, eprint = {http://ijrr.com/article-1-37-en.pdf}, journal = {International Journal of Radiation Research}, issn = {2322-3243}, eissn = {2345-4229}, year = {2004} } @article{ author = {P.Abdolmaleki, and M.MokhtariDizaji, and M.R.Vahead, and M.Gity,}, title = {Logistic discriminant analysis of breast cancer using ultrasound measurements}, abstract ={Background: Logistic discriminant method was applied to differentiate malignant from benign in a group of patients with proved breast lesions on the basis of ultrasonic parameters. Materials and Methods: Our database include 273 patients' ultrasonographic pictures consisting of 14 quantitative variables. The measured variables were ultrasound propagation velocity, acoustic impedence and attenuation coefficient at 10 MHz in breast lesions at 20, 25, 30 and 35 º C temperature, physicsl density and age. This database was randomly divided into the estimation of 201 and validation of 72 samples. The estimation samples were used to build the logistic discriminant model, and validation samples were used to validate the performance. Finally, important criteria such as sensitivity, specificity, accuracy and area under the receiver operating characteristic curve (ROC) were evaluated. Results: Our results showed that the logistic discriminant method was able to classify correctly 67 out of 72 cases presented in the validation sample. The results indicate a remarkable diagnostic accuracy of 93%. Conclusion: A logistic discriminantor approach is capable of predicting the probability of malignancy of breast cancer. Features extracted from ultrasonic measurement on ultrasound imaging is used in this approach. Iran . J. Radiat. Res., 2004 2 (1): 27-34}, Keywords = {, ultrasonic tissue characterization, ultrasonic imaging, logistic discriminant analysis, receiver operating characteristic curve (ROC)}, volume = {2}, Number = {1}, pages = {27-34}, publisher = {Dr. Hossein Mozdarani}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijrr.com/article-1-38-en.html}, eprint = {http://ijrr.com/article-1-38-en.pdf}, journal = {International Journal of Radiation Research}, issn = {2322-3243}, eissn = {2345-4229}, year = {2004} } @article{ author = {F.Abbasisiar, and T.Hosseini, and A.Fathivand, and Gh.Heravi,}, title = {Determination of uranium isotopes (234U, 238U) and natural uranium (U-nat) in water samples by alpha spectrometry}, abstract ={Background: Due to the potential public health effects of releases of uranium to the environment, isotopic determination and measurement of this radionuclide in environmental samples is very important. Achieving this goal, monitoring programs for this radionuclide seems necessary to be applied in many countries. Materials and Methods: The uranium was separated from the water samples using anion exchange resin (Dowex 1×8 Cl- form) and then purified by electrodeposition or co-precipitation method with Lanthanide fluorides such as Lanthanum fluoride (LaF3) and finally the prepared source it is counted by Alpha spectrometry. Results: The activity of 234U, 238U and natural uranium (U-nat) in 4 water samples, sent by Analytical Quality Control Services (AQCS) center of International Atomic Energy Agency (IAEA), were determined and the results were compared with the AQCS laboratories data. The ranges of measured activities for low and high activity samples were from 3.217×10-3 to 597 Bq/kg respectively. Conclusion: Since the results were relatively close to the AQCS data, the applied procedure seems to be proper for isotopic uranium determination. It was observed that in case of low activity level samples, preparing source by co-precipitation method showed more accurate results. Iran . J. Radiat. Res., 2004 2 (1): 35-40}, Keywords = {, activity, anion exchange resin, electrodeposition, co-precipitation, alpha spectrometry}, volume = {2}, Number = {1}, pages = {35-40}, publisher = {Dr. Hossein Mozdarani}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijrr.com/article-1-39-en.html}, eprint = {http://ijrr.com/article-1-39-en.pdf}, journal = {International Journal of Radiation Research}, issn = {2322-3243}, eissn = {2345-4229}, year = {2004} } @article{ author = {T.Hosseini, and A.A.Fathivand,}, title = {Measurement of radium micro-precipitates using alpha spectrometry and total alpha counting methods}, abstract ={Background: This study consists of two parts. The first part deals with both qualitative and quantitative analysis of 226Ra using alpha spectrometry measurement method. In the second part, the percentage of radioactive equilibrium between 226 Ra and its daughter products were determined by alpha spectrometry and total alpha measurement system after elapsed time of 15 days from precipitation. Materials and Methods: Twelve 226Ra samples as barium-radium sulfate in form of micro-precipitate on millipore and Whatman #42 filters were prepared. An alpha spectrometer with surface barrier detector and a total alpha measurement system consists of scintillation crystal assembly ZnS (Ag) were used for counting. Results: The minimum detection limit of alpha spectrometry and total alpha counting for 226Ra measurements in samples for counting time equal to 10000 seconds, were found to be 3.7 mBq and 15.8 mBq respectively. Results from total alpha counting showed that radioactive equilibrium between 226Ra and its daughter products reached to about 92%±3.5, where as, in the case of alpha spectrometry radioactive equilibrium, it was destroyed due to vacuum during counting the sample. Also in case of alpha spectrometry, the optimum sample to detector distance, was found to be 0.5 centimeter. Conclusion: From this study it was concluded that micro-precipitation can be used as a proper method for sample preparation and alpha spectrometry due to its lower detection limit to measure low concenteration of 224Ra and 226Ra in these precipitates, prepared from different samples. Besides it is not time consuming and sources can be measured immediately after sample preparation. Iran . J. Radiat. Res., 2004 2 (1): 41-44}, Keywords = {, micro-precipitate, millipore and Whatman filters, alpha spectrometry, total alpha counter}, volume = {2}, Number = {1}, pages = {41-44}, publisher = {Dr. Hossein Mozdarani}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijrr.com/article-1-40-en.html}, eprint = {http://ijrr.com/article-1-40-en.pdf}, journal = {International Journal of Radiation Research}, issn = {2322-3243}, eissn = {2345-4229}, year = {2004} } @article{ author = {P.Rowshanfarzad, and A.R.Jalilian, and M.Sabet,}, title = {Simultaneous production and quality control of 73Se and 75Se radioisotopes in a 30 MeV cyclotron}, abstract ={Background : Selenium-73 (T 1/2 =7.1h) and Selenium-75 (T 1/2 =119.8d) are useful radioisotopes in many research fields. The wide ranges of applications of these radioisotopes arose great interest for their production. Simultaneous production of 73 Se and 75 Se is more cost-effective and less time-consuming. Materials and Methods : 73 As (p, 3n) 73 Se and 75 As (p,n) 75 Se reactions were determined as the best choices for the production of 73 Se and 75 Se radioisotopes, according to the present facilities and conditions. The bombardment was performed by 30 MeV protons in Cyclone 30-IBA accelerator. ALICE and SRIM nuclear codes were used to determine the best energy and target thicknesses. Targets were specifically designed for simultaneous production of the radioisotopes as two consecutive pellets. Chemical processing was performed by no carrier added solvent extraction method. Radio-TLC was performed on polymer backed silica gel. A colorimetricmethod was used for chemical quality control. Radionuclidic quality control of the inal products was carried out by gamma spectroscopy with HPGe detector. Results: The production yield was 5.3 mCi/µAh for 73 Se and 50 µCi/µAh and 678 µCi/µAh for 75 Se in the first and second pellets respectively. The specific activity of 73 Se was 1.06 mCi/ml and that of 75 Se was 135.6 µCi/ml after one hour of proton bombardment with a current of 5µA. The isotopic purity of 73 Se was 99% in the first pellet and that of 75 Se was 100% in the second, just after the end of bombardment. A 0.04 ppm colorimetric method showed no traces of arsenic in the final product. Conclusion : The quick and inexpensive procedure used in this research, resulted in high yields,high chemical and high isotopic purity for both radioisotopes. It can be considered as the method of choice for simultaneous production of 73 Se and 75 Se. Iran . J. Radiat. Res., 2004 2 (1): 45-51}, Keywords = {, Selenium-73, cyclotron, simultaneous production, quality control}, volume = {2}, Number = {1}, pages = {45-51}, publisher = {Dr. Hossein Mozdarani}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijrr.com/article-1-41-en.html}, eprint = {http://ijrr.com/article-1-41-en.pdf}, journal = {International Journal of Radiation Research}, issn = {2322-3243}, eissn = {2345-4229}, year = {2004} }