en
jalali
1397
1
1
gregorian
2018
4
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online
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fulltext
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A review on combined biological effects of microwave and other physical or chemical agents
With the development of science and technology, microwave has been used in many fields such as industry, military, medicine and communication. People are living in a lapped and dynamic electromagnetic environment. Concerns about potential hazards of microwave are getting increasing attentions. The single biological effects of microwave were widely discussed which was considered harmful. Relevant safety standards had been formulated and applied. However, the real environment was more complex. Microwave was not the only factor that organisms might be affected. Other physical or chemical factors, such as ionizing radiation (IR), ultraviolet (UV), magnetic field and chemical drugs, often existed with the microwave radiation. Even the microwave itself could create combined exposure situation, because the environment consisted different frequency microwaves. Nuclear weapons and high-power radar could produce microwave and ionizing radiation. The ultraviolet ray and magnetic field generated by the instrument's operation could act on the human bodies along with the microwaves. The combination of radiofrequency therapy and chemotherapeutic agents was also commonly used in cancer therapy. Therefore, the combined biological effects of microwaves and other physical or chemical factors were very important. This review had covered the original articles in this aspect. In order to better understand the combined biological effects, the comparative studies of different frequency microwaves were also included. Differences in biological effects were found among different frequency microwaves, and the combined biological effects contained both hazards and benefits. Findings in combined biological effects were very practical for rational uses of microwave technologies.
Combined biological effects, microwave, ionizing radiation, laser, ultraviolet light, drug, magnetic field.
139
153
http://ijrr.com/browse.php?a_code=A-10-1-724&slc_lang=en&sid=1
2018/07/18
1397/4/27
2018/07/18
1397/4/27
S.
Tan
Department of Experimental Pathology and Division of Radiation Protection and Health Physics, Beijing Institute of Radiation Medicine, Beijing, P.R. China
00319475328460011476
00319475328460011476
No
H.
Wang
Department of Experimental Pathology and Division of Radiation Protection and Health Physics, Beijing Institute of Radiation Medicine, Beijing, P.R. China
wanghui597bj@163.com
00319475328460011477
00319475328460011477
Yes
R.
Peng
Department of Experimental Pathology and Division of Radiation Protection and Health Physics, Beijing Institute of Radiation Medicine, Beijing, P.R. China
ruiyunpeng18@126.com
00319475328460011478
00319475328460011478
No
en
Effect of human amnion-derived multipotent progenitor cells on hematopoietic recovery after total body irradiation in C57BL/6 mice
Background: The hematopoietic system is sensitive to the adverse effects of ionizing radiation. Cellular therapies utilizing mesenchymal stem cells or vascular endothelial cells have been explored as potential countermeasures for radiation hematopoietic injuries. We investigated cells cultured from amnion (Amnion-derived Multipotent Progenitor cells, AMPs) for effects on hematopoietic recovery following total body irradiation in mice. Materials and Methods: C57BL/6J mice were sham-irradiated or exposed to 60Co irradiation (7.75 – 7.90 Gy, 0.6 Gy/min). Either AMPs (5 × 106 cells/animal) or vehicle were administered 24 h postirradiation via intraperitoneal injection. Results: We observed a 13% and 20% improvement in 30-day survival of mice treated with AMPs compared with treatment with vehicle following irradiation at 7.75 and 7.90 Gy, respectively. AMP treatment was characterized by a trend toward accelerated recovery of white blood cells, neutrophils, reticulocytes, and monocytes, measured through day 40 postirradiation after 7.75 Gy. AMP treatment enhanced hematopoietic cell repopulation of spleen and femoral bone marrow as measured by total nucleated cell and hematopoietic progenitor cell counts in comparison to vehicle-treated animals. FACS analysis showed that AMPs treatment significantly mitigated the reduction in CD11b+/Gr-1int and CD11b+/Gr-1high bone marrow cell populations at the nadir, and improved recovery of these cell types. Conclusion: Together, our data indicate that AMPs reduced hematopoietic toxicity induced by ionizing radiation when infused within 24 h after radiation injury.
adult stem cells, acute radiation syndrome, ionizing radiation, radiation countermeasure, hematopoietic progenitor.
155
168
http://ijrr.com/browse.php?a_code=A-10-1-713&slc_lang=en&sid=1
2018/07/182018/07/16
1397/4/25
2018/07/182018/07/16
1397/4/25
Y.
Du
Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
00319475328460011367
00319475328460011367
No
R.A.
Banas
Noveome Biotherapeutics. Pittsburgh, PA 15219, USA
00319475328460011368
00319475328460011368
No
E.A.
McCart
Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
00319475328460011369
00319475328460011369
No
J.
George
Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
00319475328460011370
00319475328460011370
No
K.
Oakley
Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
00319475328460011371
00319475328460011371
No
Y.
Han
Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
00319475328460011372
00319475328460011372
No
M.R.
Landauer
Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
00319475328460011373
00319475328460011373
No
R.M.
Day
Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Regina.day@usuhs.edu
00319475328460011374
00319475328460011374
Yes
en
Optimization of prostate cancer radiotherapy using of a spacer gel, volumetric modulated arc therapy and a single biological organ at risk objective
Background: The aim was to evaluate the benefit of technical advances for treatment planning: introduction of a hydrogel spacer, VMAT (volumetric modulated arc therapy) and a single biological organ at risk objective for the rectum and bladder. Initial standard was a step-and-shoot IMRT (intensity modulated radiotherapy) without a spacer and conventional organ at risk objectives. Materials and Methods: Treatment plans were calculated using IMRT and VMAT techniques before and after spacer injection in 27 patients, respectively. Conventional organ at risk objectives have been used for the optimization of IMRT plans, only a single biological organ at risk objective for VMAT plans. VMAT vs. IMRT plans and plans before vs. after spacer injection were compared. Results: VMAT plans and independently the spacer demonstrated improved dose homogeneity, whereas VMAT additionally displayed improved dose conformity. The dose to the bladder and rectum could be significantly decreased applying the VMAT technique (mean rectum volumes of 14%/10%/5% in VMAT vs. 36%/24%/12% in IMRT within the 50Gy/60Gy/70Gy isodoses; p<0.01). NTCP for ≥grade 3 rectum toxicity could be accordingly decreased with the VMAT technique (3.6 vs. 0.9% for IMRT vs. VMAT; p<0.01) and the spacer gel (3.3 vs. 1.2% for plans without vs. with spacer gel; p<0.01) – only 0.3% with VMAT and spacer gel. Conclusion: In addition to the decreased rectal dose following spacer injection, VMAT with single biological organ at risk optimization resulted in further dose reduction to the organs at risk and improved dose homogeneity and conformity in comparison to the step-and-shoot IMRT technique with conventional objectives.
Prostate cancer, intensity-modulated radiotherapy, volumetric modulated arc therapy, treatment planning, spacer gel.
169
176
http://ijrr.com/browse.php?a_code=A-10-1-714&slc_lang=en&sid=1
2018/07/182018/07/162018/07/16
1397/4/25
2018/07/182018/07/162018/07/16
1397/4/25
M.
Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Pauwelsstrasse 30, 52072 Aachen, Germany
Michael.Pinkawa@post.rwth-aachen.de
00319475328460011376
00319475328460011376
Yes
C.
Schubert
Department of Radiation Oncology, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
00319475328460011377
00319475328460011377
No
N.
Escobar-Corral
Department of Radiation Oncology, RWTH Aachen University, Pauwelsstrasse 30, 52072 Aachen, Germany
00319475328460011378
00319475328460011378
No
V.
Berneking
Department of Radiation Oncology, RWTH Aachen University, Pauwelsstrasse 30, 52072 Aachen, Germany
00319475328460011379
00319475328460011379
No
M.J.
Eble
Department of Radiation Oncology, RWTH Aachen University, Pauwelsstrasse 30, 52072 Aachen, Germany
00319475328460011380
00319475328460011380
No
en
Clinical evaluation of simultaneous integrated boost in brain metastasis patients with helical intensity modulated radiotherapy
Background: This study was performed to assess patient survival and treatment toxicity after helical tomotherapy (HT) with simultaneous integrated boost (SIB) radiotherapy (RT) for cancer patients with one to eight brain metastases (BM) who have been treated with or without surgery. Materials and Methods: A total of 48 brain metastasis (BM) patients were included in this retrospective study between April 2015 and December 2016,. The patients were treated with image-guided intensity modulated radiation therapy (IMRT) on the helical tomotherapy (HT) machine. Whole brain HT as 25 Gy and SIB to metastasis sites as 35 Gy was delivered in 10 fractions. The patient were aged between 50 to 80 years old, volume of the BM was between 6 to 75 cc and the number of brain metastasis was between 1 to 8, Karnofsky Performance Score (KPS) ranged between 50-90 and RPA I-III. Surgery was performed to two patients before RT. The maximum patient follow-up time was 20 months. Results: The primary neurotoxicity observed in patients was grade I- II brain edema related headache and lethargy. In patients who had survived 3- 12 months, KPS improved median score of 20 points and RPA was grade I after six months. Twelve patients had passed away at the end of a 20- month follow-up. Conclusion: HT utilizing SIB treatment for 1- 8 BM was achieved successfully with no significant toxicity. An improvement of performance status indicators of patients following RT was observed.
Simultaneous integrated boost, brain metastasis, Tomotherapy, radiotherapy.
177
183
http://ijrr.com/browse.php?a_code=A-10-1-715&slc_lang=en&sid=1
2018/07/182018/07/162018/07/162018/07/16
1397/4/25
2018/07/182018/07/162018/07/162018/07/16
1397/4/25
A.
Mayadagli
Department of Radiation Oncology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
alpdag@hotmail.com
00319475328460011971
00319475328460011971
Yes
H.S
Kiziltan
Department of Radiation Oncology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
00319475328460011972
00319475328460011972
No
I.
Kingir Celtik
Department of Radiation Oncology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
00319475328460011973
00319475328460011973
No
K.
Berk
Department of Radiation Oncology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
00319475328460011974
00319475328460011974
No
E.
Tekce
Department of Radiation Oncology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
00319475328460011975
00319475328460011975
No
A.H.
Eris
Department of Radiation Oncology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
00319475328460011976
00319475328460011976
No
H.
Seyithanoglu
Department of Radiation Oncology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
00319475328460011977
00319475328460011977
No
en
Demographic characteristics and prognostic factors in pediatric-type sarcomas; A 7 year single institutional experience and comprehensive review of the current literature
Background: Due to limited clinical data in pediatric-type sarcomas (rhabdomyosarcoma, Ewing's sarcoma, PNET, and desmoplastic small round-cell tumor), the aim of this study was to evaluate the demographic characteristics and identifying prognostic factors for survival. Materials and Methods: We retrospectively reviewed 110 patients with pediatric-type sarcomas. Overall and disease free survival was analyzed with the Kaplan-Meier method and log rank test. To identify prognostic factors for overall and disease free survival, multivariate survival analyses using a Cox’s proportional-hazard regression model was performed. Results: In this study mean age of patients were 20.30 years (SD=13.61; range, 1–83 years). The survival data of 54 patients (49.1%) were obtained with median survival of 27 months. 3 and 5-year survival rate of these patients were 41.5% and 28.3% respectively. Recurrence of disease (P=0.006) and Ewing sarcoma subtype (P=0.018) were significantly associated with poor overall survival and location of the lesion in the upper extremities (P=0.007) and trunk (P=0.005) were significantly associated with a lower disease free survival. Conclusion: With multivariate analysis, the authors determined that recurrence of disease and Ewing's sarcoma subtype are poor prognostic factors for overall survival and site of origin for disease free survival among patients with pediatric-type sarcoma. In addition, gender, patient's age, and size of tumor had no significant impact on overall and disease free survival.
Cancer, prognostic factor, sarcoma, small round cell, survival.
185
195
http://ijrr.com/browse.php?a_code=A-10-1-716&slc_lang=en&sid=1
2018/07/182018/07/162018/07/162018/07/162018/07/16
1397/4/25
2018/07/182018/07/162018/07/162018/07/162018/07/16
1397/4/25
E.
Esmati
Department of Radiation Oncology, Cancer Institute, Imam Khomeini Hospital, Keshavarz Blvd, Tehran, Iran
00319475328460011394
00319475328460011394
No
A.
Maddah Safaei
Department of Radiation Oncology, Cancer Institute, Imam Khomeini Hospital, Keshavarz Blvd, Tehran, Iran
afsan1980@ymail.com
00319475328460011395
00319475328460011395
Yes
H.
Nosrati
Department of Radiation Oncology, Cancer Institute, Imam Khomeini Hospital, Keshavarz Blvd, Tehran, Iran
00319475328460011396
00319475328460011396
No
M.
Babaei
Department of Radiation Oncology, Cancer Institute, Imam Khomeini Hospital, Keshavarz Blvd, Tehran, Iran
00319475328460011397
00319475328460011397
No
M.
Lashkari
Department of Radiation Oncology, Cancer Institute, Imam Khomeini Hospital, Keshavarz Blvd, Tehran, Iran
00319475328460011398
00319475328460011398
No
F.
Amouzegar Hashemi
Department of Radiation Oncology, Cancer Institute, Imam Khomeini Hospital, Keshavarz Blvd, Tehran, Iran
00319475328460011399
00319475328460011399
No
F.
Farhan
Department of Radiation Oncology, Cancer Institute, Imam Khomeini Hospital, Keshavarz Blvd, Tehran, Iran
00319475328460011400
00319475328460011400
No
M.
Mirai Ashtiani
Department of Radiation Oncology, Cancer Institute, Imam Khomeini Hospital, Keshavarz Blvd, Tehran, Iran
00319475328460011401
00319475328460011401
No
N.
Khanjani
Department of Radiation Oncology, Cancer Institute, Imam Khomeini Hospital, Keshavarz Blvd, Tehran, Iran
00319475328460011402
00319475328460011402
No
A.
Alibakhshi
Department of Surgery, Valieasr Hospital, Keshavarz Blvd, Tehran, Iran
00319475328460011403
00319475328460011403
No
en
Effect of dose rate on antitumor activity in hypoxic cells by using flattening filter free beams
Background: Recently, the Flattening Filter Free (FFF) beams, which allow a dose rate increase of up to four times compared to the normal dose rate, have been incorporated into radiation therapy machines. The aim of this study is to evaluate antitumor activity in hypoxic cells irradiated with different dose rates using FFF beams and to identify the casual mechanism for cellular damage during irradiation. Materials and Methods: EMT6 cells were treated with 95% N2 and 5% CO2 to maintain a hypoxic condition. Three dose rates, namely, 6.27 Gy/min, 12.00 Gy/min, and 18.82 Gy/min, were used to deliver the prescribed dose of 2 to 4 Gy using the TrueBeam linear accelerator. The number of colonies was counted to evaluate the cell surviving fraction. To investigate the mode of action, additional experiments to detect reactive oxygen species (ROS) by aminophenyl fluorescein (APF) assay, and DNA double-strand breaks (DSBs) by γH2AX assay were performed. Results: Irradiation of hypoxic cells using FFF beams increases antitumor activity as a function of dose rate. The fluorescence of the APF assay was significantly increased when high dose rates were used. In addition, results from our γH2AX assays show that the number of DNA DSBs increased as a function of dose rate, in hypoxic cells. Conclusion: We demonstrate that there is a significant dose rate-dependent difference in antitumor activity in hypoxic cells, when FFF beams are used.
Flattening filter free (FFF), radiation biology, hypoxic cell, dose rate effect.
197
205
http://ijrr.com/browse.php?a_code=A-10-1-717&slc_lang=en&sid=1
2018/07/182018/07/162018/07/162018/07/162018/07/162018/07/16
1397/4/25
2018/07/182018/07/162018/07/162018/07/162018/07/162018/07/16
1397/4/25
T.
Hara
Graduate School of Technology and Science, Tokushima University, Tokushima, Japan
00319475328460011405
00319475328460011405
No
M.
Tominaga
Institute of Health Science, Tokushima University, Tokushima, Japan
00319475328460011406
00319475328460011406
No
K.
Yajyu
Graduate School of Technology and Science, Tokushima University, Tokushima, Japan
00319475328460011407
00319475328460011407
No
R.
Kouzaki
Graduate School of Technology and Science, Tokushima University, Tokushima, Japan
00319475328460011408
00319475328460011408
No
A.
Hanyu
Graduate School of Technology and Science, Tokushima University, Tokushima, Japan
00319475328460011409
00319475328460011409
No
H.
Yamada
Institute of Bioscience and Bioindustry, Tokushima University, Tokushima, Japan
00319475328460011410
00319475328460011410
No
M.
Sasaki
Institute of Bioscience and Bioindustry, Tokushima University, Tokushima, Japan
00319475328460011411
00319475328460011411
No
S.
Azane
Institute of Bioscience and Bioindustry, Tokushima University, Tokushima, Japan
00319475328460011412
00319475328460011412
No
Y.
Uto
Institute of Bioscience and Bioindustry, Tokushima University, Tokushima, Japan
uto.yoshihiro@tokushima-u.ac.jp
00319475328460011413
00319475328460011413
Yes
en
Natural radioactivity of some Egyptian materials used in glasses manufacturing and glass ceramics
Background: The new glasses from harmful environmental waste such as cement dust; limestone phosphate, sand and borax (Genkare) were manufactured. Investigation of the radioactivity present in these materials (Phosphate rock, cement dust, limestone, sand and borax) enables one to assess any possible radiological hazard to humankind by such materials. Materials and Methods: Fifteen samples were collected from five locations. Activity measurements have been performed by gamma-ray spectrometer, employing a high-resolution scintillation detector NaI (Tl) crystal 3 ×3 inch. In addition, the radiological hazards were calculated for the investigated samples. Results: The average values of activity ranged from 28±2 to 163±12, 2.8±0.7 to 40±3 and from 49±4 to 1337±74 Bq kg-1 for 226R, 232Th and 40K, respectively. The values of absorbed dose rates, radium equivalent activities and annual effective dose due to 226Ra, 232Th and 40K respectively, are ranged from 22.05 to 101.59 nGy h-1, 45.90 to 224.22 Bq kg-1 and 27.04 to 124.59 µSv y-1. In addition, the values of external hazard index, internal hazard index and gamma index have been calculated. Conclusion: According to the obtained results, all materials would not present a significant radiological hazard except phosphate. The results of the study could serve as important baseline radiometric data for future epidemiological studies and monitoring initiatives.
Natural radioactivity, glass ceramics radiological hazards, phosphate rock, cement dust, limestone, sand, borax and glasses.
207
215
http://ijrr.com/browse.php?a_code=A-10-1-718&slc_lang=en&sid=1
2018/07/182018/07/162018/07/162018/07/162018/07/162018/07/162018/07/16
1397/4/25
2018/07/182018/07/162018/07/162018/07/162018/07/162018/07/162018/07/16
1397/4/25
R.
Elsaman
Physics Department, Faculty of Science, Al–Azhar University, Assiut 71524, Egypt
reda_m8282@yahoo.com
00319475328460011427
00319475328460011427
Yes
G. A. M.
Ali
Chemistry Department, Faculty of Science, Al–Azhar University, Assiut, 71524, Egypt
00319475328460011428
00319475328460011428
No
M. A. M.
Uosif
Physics Department, Faculty of Science, Al–Azhar University, Assiut 71524, Egypt
00319475328460011429
00319475328460011429
No
K. H. S.
Shaaban
Chemistry Department, Faculty of Science, Al–Azhar University, Assiut, 71524, Egypt
00319475328460011430
00319475328460011430
No
Y. B.
Saddeek
Physics Department, Faculty of Science, Al–Azhar University, Assiut 71524, Egypt
00319475328460011431
00319475328460011431
No
K. A.
Aly
Physics Department, Faculty of Science, Al–Azhar University, Assiut 71524, Egypt
00319475328460011432
00319475328460011432
No
K. F.
Chong
Faculty of Industrial Sciences and Technology, University Malaysia Pahang, Gambang, 26300 Kuantan, Malaysia
00319475328460011433
00319475328460011433
No
en
Vitamin E protects rat testis, eye and erythrocyte from oxidative stress during exposure to radiofrequency wave generated by a BTS antenna model
Background: Radio frequency wave (RFW) generated by mobile phones and wireless communication systems has been reported to cause adverse effects on reproductive function, vision and hematological parameters, possibly through oxidative stress. The aim of this study was to evaluate the effect of RFW generated bybase transceiver station BTS on oxidative stress in testis, eye and erythrocyte, and the prophylactic effect of vitamin E by measuring the antioxidant enzymes activity, including: glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT), and lipid proxidation. Materials and Methods: Thirty-two adult male Sprague–Dawley rats were randomly divided into four groups and treated daily for 45 days as follows: control, treatment control (vitamin E 200 mg/kg of body weight/day by gavage), sham exposed group (exposed to 900 MHz RFW), and treatment group (received vitamin E and exposed to RFW). Control and treatment control groups were not exposed and were only given the vehicle, i.e., distilled water. On the last day of the study, all the rats were sacrificed and their testes, eyes and erythrocyte were collected and used for measurement of antioxidant enzymes activity and lipid peroxidation. Results: Exposure to RFW in the sham exposed group decreased antioxidant enzymes activity and increased lipid peroxidation compared to both control groups (p<0.05). In the treatment group, vitamin E improved antioxidant enzymes activity and reduced lipid peroxidation compared to the sham exposed group (p<0.05). Conclusion: RFW causes oxidative stress in eye, testis and erythrocytes and vitamin E improved oxidative stress in these tissues.
Oxidative stress, radio frequency wave, testis, eye, erythrocyte, vitamin E.
217
224
http://ijrr.com/browse.php?a_code=A-10-1-719&slc_lang=en&sid=1
2018/07/182018/07/162018/07/162018/07/162018/07/162018/07/162018/07/162018/07/16
1397/4/25
2018/07/182018/07/162018/07/162018/07/162018/07/162018/07/162018/07/162018/07/16
1397/4/25
G.
Jelodar
Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz 71345, Iran
Jelodar@shirazu.ac.ir
00319475328460011423
00319475328460011423
Yes
A.
Akbari
Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz 71345, Iran
00319475328460011424
00319475328460011424
No
P.
Parvaeei
Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz 71345, Iran
00319475328460011425
00319475328460011425
No
S.
Nazifi
Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz 71345, Iran
00319475328460011426
00319475328460011426
No
en
Prospective-triggered high-pitch spiral versus sequential dual-source CT coronary angiography: comparison of image quality and radiation dose
Background: Prospectively electrocardiography (ECG)-triggered high-pitch spiral coronary computed tomography angiography (CCTA) is a unique scan mode for dual-source CT (DSCT). Our reports aim to compare image quality and radiation dose of CCTA using high-pitch spiral or sequential acquisition mode in patients with low and stable heart rates. Materials and Methods: Patients with low and stable heart rates (HR) (HR ≤ 70 beats per minute [bpm]; heart rate variability [HRV] < 10 bpm) were randomly assigned to high-pitch spiral mode (group A; n = 80) or sequential acquisition mode (group B; n = 80). Image quality scores, image noise, effective radiation dose and influencing factors on image quality were assessed. Results: Mean image quality scores were 1.51 ± 0.32 and 1.70 ± 0.38 for groups A and B (P < 0.05), respectively. Image noises of the two groups were 19.05±4.70 Hu and 27.21±8.88 Hu (P < 0.05). Contrast media cost in group A was lower than group B (P < 0.05). No statistical difference was found in the rate of diagnostic patients between the two groups (P = 0.416). The estimated radiation dose of group A was 26.0% reduced compared with group B (0.74 ± 0.34 mSv vs. 1.00 ± 0.48 mSv, P < 0.05). Conclusion: In patients with regular and low heart rates, the prospectively high-pitch spiral acquisition mode can reduce radiation dose and contrast media cost while maintaining image quality compared with the prospectively sequential mode.
Tomography, X-ray computed, coronary angiography, image quality, radiation dose.
225
233
http://ijrr.com/browse.php?a_code=A-10-1-720&slc_lang=en&sid=1
2018/07/182018/07/162018/07/162018/07/162018/07/162018/07/162018/07/162018/07/162018/07/17
1397/4/26
2018/07/182018/07/162018/07/162018/07/162018/07/162018/07/162018/07/162018/07/162018/07/17
1397/4/26
Y.
Zhuang
Shandong Medical Imaging Research Institute, Shandong University, No. 324, JingWu Road, Jinan 250021, Shandong, China
00319475328460011447
00319475328460011447
No
W.
Huang
Department of Medical Imaging, Huai’an First People’s Hospital, Affiliated to Nanjing Medical University No.6, Western Beijing Road, Huanyin District, Huai’an 223300, Jiangsu, China
00319475328460011448
00319475328460011448
No
Y.
Shi
Digestive Department, Huai’an First People’s Hospital, Affiliated to Nanjing Medical University No.6, Western Beijing Road, Huanyin District, Huai’an 223300, Jiangsu, China
00319475328460011449
00319475328460011449
No
G.
Bo
Department of Medical Imaging, Huai’an First People’s Hospital, Affiliated to Nanjing Medical University No.6, Western Beijing Road, Huanyin District, Huai’an 223300, Jiangsu, China
00319475328460011450
00319475328460011450
No
D.
Lu
Department of Medical Imaging, Huai’an First People’s Hospital, Affiliated to Nanjing Medical University No.6, Western Beijing Road, Huanyin District, Huai’an 223300, Jiangsu, China
00319475328460011451
00319475328460011451
No
J.
Zhang
Department of Medical Imaging, Huai’an First People’s Hospital, Affiliated to Nanjing Medical University No.6, Western Beijing Road, Huanyin District, Huai’an 223300, Jiangsu, China
00319475328460011452
00319475328460011452
No
D.
Kong
Department of Medical Imaging, Huai’an First People’s Hospital, Affiliated to Nanjing Medical University No.6, Western Beijing Road, Huanyin District, Huai’an 223300, Jiangsu, China
00319475328460011453
00319475328460011453
No
Y.
Shi
Department of Medical Imaging, Huai’an First People’s Hospital, Affiliated to Nanjing Medical University No.6, Western Beijing Road, Huanyin District, Huai’an 223300, Jiangsu, China
00319475328460011454
00319475328460011454
No
B.
Wang
Binzhou Medical University, No. 346, Guanhai Road, Laishan District, Yantai 264003, Shandong, China
binwang001@aliyun.com
00319475328460011455
00319475328460011455
Yes
en
Investigation of the effects of a carbon-fiber tabletop on the surface dose and attenuation dose for megavoltage photon beams
Background: Multiple beams are generally used with an increased possibility that the beam axis intersects the treatment table. Treatment tabletops are commonly made of carbon fiber due to its high mechanical strength and rigidity, low specific density, extremely light and low radiation beam attenuation properties. Purpose of this paper is investigated the dose changes in the buildup region and beam attenuation by a carbon fiber tabletop for high energy 6- and 18-MV photon beams. Materials and Methods: Measurements were performed for 10 cm × 10 cm and 20 cm × 20 cm field sizes. The surface dose and percentage depth doses (%DD) were measured by a Markus parallel plate chamber at a source-surface distance (SSD) of 100 cm for 6 MV and 18 MV photon beams. Attenuation measurements were made at the solid-water phantom for gantry angles of 0o and 180o rotation of the beam. Results: A carbon fiber tabletop increases the surface dose from 12.87% to 86.65% for 10 cm x 10 cm and from 8.72% to 71.16% for 20 cm × 20 cm field at 6 and 18 MV, respectively. The surface dose with the carbon fiber tabletop in an open field (0o) increases with field size. Conclusion: The carbon fiber tabletop causes a substantially increased surface dose, and also significantly decreases the skin-sparing effect, which is clinically important. The dosimetric effect of the tabletop may be higher, especially for the intensity-modulated radiation therapy depending on the beam orientation.
Radiation, radiotherapy, carbon fiber tabletop, surface dose, buildup region.
235
241
http://ijrr.com/browse.php?a_code=A-10-1-721&slc_lang=en&sid=1
2018/07/182018/07/162018/07/162018/07/162018/07/162018/07/162018/07/162018/07/162018/07/172018/07/18
1397/4/27
2018/07/182018/07/162018/07/162018/07/162018/07/162018/07/162018/07/162018/07/162018/07/172018/07/18
1397/4/27
G.
Gursoy
Department of Medical Services and Technical, Vocational School of Health Services, Ahi Evran University, Kırşehir, Turkey
00319475328460011457
00319475328460011457
No
E.
Eser
Department of Physics, Polatlı Faculty of Arts and Sciences, Gazi University, Ankara,Turkey
eserphy@gmail.com
00319475328460011458
00319475328460011458
Yes
I.
Yigitoglu
Department of Physics, Faculty of Arts and Sciences, Gaziosmanpasa University, Tokat,Turkey
00319475328460011459
00319475328460011459
No
H.
Koç
Department of Electrical and Electronics Engineering, Faculty of Engineering, Muş Alparslan University, Muş, Turkey
00319475328460011460
00319475328460011460
No
F.C.
Kahraman
Provincial Health Directorate, Isparta, Turkey
00319475328460011461
00319475328460011461
No
S.
Yamcıcier
Department of Medical Services and Technical, Vocational School of Health Services, Ahi Evran University, Kırşehir, Turkey
00319475328460011462
00319475328460011462
No
en
The possibility of hormone-mediated PSA derangement in prostate cancer treatment
Background: This study was designed to suggest the possibility of hormone-related derangement in salvage radiotherapy (SRT) after radical prostatectomy in terms of prostate-specific antigen (PSA) control. Materials and Methods: Among 160 consecutive prostate cancer patients who received radical prostatectomy, 34 with SRT between 2004 and 2012 were retrospectively reviewed. The numbers of patients with pathologic T3-T4 stage, Gleason score 8-10, and positive resection margin were 11 (32.4%), 10 (29.4%), and 17 (50.0%), respectively. Median SRT dose was 64.8 Gy (range, 52.9-70.0 Gy) with 1.8-2.3 Gy fractionations. Biochemical failure-free survival after SRT was counted and the median follow-up period was 32.5 months (range, 10-118 months). Results: After SRT, the median time for PSA to decrease to less than 0.2 ng/mL was four months (range, 0-25 months). The three-year survival rate was 60.3%. On univariate analysis, preferential hormone therapy (PHT) (p=0.022), higher PSA at SRT (p=0.005), and higher PSA after surgery (p=0.003) were related to a shorter biochemical survival period. On multivariate analysis, lower PSA at SRT (p=0.016), higher radiation dose (p=0.007), and non-PHT (p=0.046) suggested a consistent PSA control. Conclusion: According to these results, low PSA values by hormonal intervention need to be reconsidered with a different way to look at the relationship between the PSA and hormone therapy. SRT should be considered for postoperative salvage treatment regardless of the hormone-related PSA values.
Hormone therapy, Prostate cancer, Salvage radiotherapy.
243
250
http://ijrr.com/browse.php?a_code=A-10-1-722&slc_lang=en&sid=1
2018/07/182018/07/162018/07/162018/07/162018/07/162018/07/162018/07/162018/07/162018/07/172018/07/182018/07/18
1397/4/27
2018/07/182018/07/162018/07/162018/07/162018/07/162018/07/162018/07/162018/07/162018/07/172018/07/182018/07/18
1397/4/27
C.G.
Lee
Department of Radiation Oncology, Yonsei University, College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea
00319475328460011464
00319475328460011464
No
J.
Lee
Department of Radiation Oncology, Yonsei University, Wonju College of Medicine, 20 Ilsan-ro, Wonju, Republic of Korea
00319475328460011465
00319475328460011465
No
S.
Kim
Department of Radiation Oncology, Yonsei University, Wonju College of Medicine, 20 Ilsan-ro, Wonju, Republic of Korea
00319475328460011466
00319475328460011466
No
S.H.
You
Department of Radiation Oncology, Yonsei University, Wonju College of Medicine, 20 Ilsan-ro, Wonju, Republic of Korea
ys3259@yonsei.ac.kr
00319475328460011467
00319475328460011467
Yes
en
Mammographic findings in different breast cancer subtypes (luminal, Her2 positive, triple negative)
Background: Prognosis and management of breast cancer are defined by different variables including histological type, grading, clinical stage, Her2+, estrogen and progesterone receptor conditions. Generally, mammography is one of the most important imaging which is done in breast cancer patients. The aim of this research was to evaluate different mammographic patterns in different breast cancer sub types. Materials and Methods: Demographic and clinicopathologic data of 128 breast cancer patients which referred to two academic hospitals were obtained from their registered files and their mammographies were reviewed by two radiologists separately. Patients were categorized into 3 groups of Luminal, triple negative and Her2+ and the checklists were filled out by research team. The mentioned data was then analyzed by the SPSS software version 16. Results: In this study we found significant difference in margins' clarity and axillary lymphadenopathy between mammographic presentations of different breast cancer subtypes (P=0.041) and (P=0.14), respectively; but the difference of other mamographic presentations including mass existence, mass size, margin type, peleomorphic calcification, micro calcification, nipple retraction, skin thickening and tissue distortion were not significantly different between three groups (P>0.05). Conclusion: Results of current study showed no significant difference between mammographic features of different invasive breast cancer subtypes except for axillary lymphadenopathy and ill-defined margins. Since the majority of patients were in premenopausal status; perhaps we can say lower sensitivity of mammography in premenopausal women couldn’t accurately distinguish mammographic differences between invasive breast cancer subtypes in this study.
Breast cancer, immunohistochemistry, mammography.
251
255
http://ijrr.com/browse.php?a_code=A-10-1-723&slc_lang=en&sid=1
2018/07/182018/07/162018/07/162018/07/162018/07/162018/07/162018/07/162018/07/162018/07/172018/07/182018/07/182018/07/18
1397/4/27
2018/07/182018/07/162018/07/162018/07/162018/07/162018/07/162018/07/162018/07/162018/07/172018/07/182018/07/182018/07/18
1397/4/27
L.
Pourali
Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
00319475328460011469
00319475328460011469
No
S.
Shahid Sales
Department of Clinical Oncology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
00319475328460011470
00319475328460011470
No
A.
Taghizadeh
Department of Clinical Oncology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
taghizadeha@mums.ac.ir
00319475328460011471
00319475328460011471
No
M.
Pezeshkirad
Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
00319475328460011472
00319475328460011472
No
D.
Farokh
Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
00319475328460011473
00319475328460011473
No
E.
Andakhshideh
Medical student, Mashhad University of Medical Sciences, Mashhad, Iran
00319475328460011474
00319475328460011474
No