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:: Volume 11, Issue 1 (1-2013) ::
Int J Radiat Res 2013, 11(1): 17-27 Back to browse issues page
Quantitative estimation of recovery parameters after combined action of ionizing radiation and chemical agents
V.G. Petin, J.K. Kim, E.S. Evstratova, L.N. Komarova
Korea Atomic Energy Research Institute, Advanced Radiation Technology Institute, Jeongeup, 580‐185 Republic of Korea , jkkim@kaeri.re.kr
Abstract:   (8586 Views)

Background: Treatment of ionizing radiation combined with chemical agents can enhance the inactivation of cells. The aim of this study was to determine the parameters involved in the inhibition of cell recovery. Materials and Methods: A mathematical model describing the process of recovery as a decrease in the effective radiation dose was used. The model includes two parameters, recovery constant and irreversible component. Both parameters were estimated quantitatively by using experimental survival and recovery data reported by others. Results: The inhibition of cell recovery might be done via either the damage of the mechanism of the recovery itself or via the formation of irreversible damage which could not be repaired at all. Both these processes could take place at the same time. Another mechanism was the higher probability to produce primary radiation damage without changing the recovery process. Conclusions: The results indicate the opportunity to search agents, selectively or simultaneously acting on the probability of recovery and the yield of irreversible radiation damage. The results obtained may have a practical use, rather than being concerned only with theoretical position.

Keywords: Radiotherapy, Chemotherapy, cell recovery, mathematical model
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Type of Study: Original Research | Subject: Radiation Biology
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Petin V, Kim J, Evstratova E, Komarova L. Quantitative estimation of recovery parameters after combined action of ionizing radiation and chemical agents. Int J Radiat Res. 2013; 11 (1) :17-27
URL: http://ijrr.com/article-1-1006-en.html

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Volume 11, Issue 1 (1-2013) Back to browse issues page
International Journal of Radiation Research
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