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:: Volume 13, Issue 4 (10-2015) ::
Int J Radiat Res 2015, 13(4): 317-324 Back to browse issues page
Radiation-induced acute kidney toxicity: Protective effect of L-carnitine versus amifostine
V. Yurut-Caloglu , M. Caloglu, T. Deniz-Yalta, T. Aktoz, D. Nurlu, N. Kilic-Durankus, E. Arda, G. Turkkan, O. İnci
Departments of Radiation Oncology, Edirne
Abstract:   (6021 Views)

Background:  The aim of the study was to compare the radioprotective efficacy in the kidney of L-carnitine to that of amifostine. Materials and Methods: Thirty three-month-old Wistar albino rats were randomly assigned to four groups: Group 1 (Control); Group 2 (Irradiation alone); Group 3 (amifostine plus irradiation); and Group 4 (L-carnitine before irradiation). The rats in Groups 2, 3, and 4 were irradiated individually with a single dose of 20 Gy to whole abdomen. L-carnitine (300 mg/kg) or amifostine (200 mg/kg) was administered 30 minutes before irradiation. Euthanasia was performed 5 days after irradiation, and kidneys were evaluated histopathologically. Results: Dilatation of Bowman’s capsule, congestion of blood vessels, and tubular epithelial degeneration were significantly different among the groups (p < 0.05). Pretreatment with both L-carnitine and amifostine reduced the radiation-induced dilatation of Bowman’s capsule (p < 0.05), congestion of blood vessels (p < 0.05), and tubular epithelial degeneration (p < 0.05). L-carnitine and amifostine were similar in protective effect. Conclusion: L-carnitine was equally effective as amifostine in protecting the kidney against acute irradiation damage.

Keywords: Amifostine, histopathology, irradiation, kidney, L-carnitine, radioprotection
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Type of Study: Original Research | Subject: Radiation Biology
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Yurut-Caloglu V, Caloglu M, Deniz-Yalta T, Aktoz T, Nurlu D, Kilic-Durankus N, et al . Radiation-induced acute kidney toxicity: Protective effect of L-carnitine versus amifostine. Int J Radiat Res. 2015; 13 (4) :317-324
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Volume 13, Issue 4 (10-2015) Back to browse issues page
International Journal of Radiation Research
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