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:: Volume 14, Number 3 (7-2016) ::
IJRR 2016, 14(3): 205-213 Back to browse issues page
Effects of Probiotics with or without Honey on Radiation-induced Diarrhea
H.s. Mansouri-Tehrani, M. Rabbani Khorasgani, Dr. M. Roayaei
Department of Radiation Oncology , Roayaei@med.mui.ac.ir
Abstract:   (979 Views)

Background: Diarrhea is a well-recognized side effect associated with pelvic radiation; however, there is not any effective common treatment for radiation-induced diarrhea. A popular alternative is probiotics, which have been used in several gastrointestinal disorders. Probiotics are live microbial food supplements. Furthermore, honey is a putative nutritional with a variety of health effects, including antibacterial, antioxidant, anti-inflammatory and prebiotic. The present study evaluated the effects of probiotic with or without honey on radiation-induced diarrhea. Materials and Methods: Sixty-seven adult patients with pelvic cancer underwent radiotherapy for four weeks. They randomized to receive probiotic (n = 22), probiotic plus honey (n = 21) or placebo (n = 24) from one week before radiotherapy for five weeks. Diarrhea grade and stool consistency score were recorded weekly according to the Common Toxicity Criteria system and the Bristol scales, respectively. Results: The results showed a decrease in the daily number of bowel movements (p = 0.003 and 0.006), diarrhea grade (p = 0.001 and 0.001) and the need for antidiarrheal medication (p = 0.021 and 0.041) also an increase in the stool consistency (p = 0.004 and 0.005) in patients who either used probiotic or probiotic plus honey (respectively), these were significant in weeks 4 and 5 of treatment. Conclusion: Probiotics with or without honey can reduce the incidence of radiation-induced diarrhea and the need for antidiarrheal medication

Keywords: Probiotics, honey, diarrhea, radiotherapy, pelvic cancer.
Full-Text [PDF 733 kb]   (470 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
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DOI: 10.18869/acadpub.ijrr.14.3.205


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Mansouri-Tehrani H, Rabbani Khorasgani M, Roayaei M. Effects of Probiotics with or without Honey on Radiation-induced Diarrhea. IJRR. 2016; 14 (3) :205-213
URL: http://ijrr.com/article-1-1763-en.html
Volume 14, Number 3 (7-2016) Back to browse issues page
International Journal of Radiation Research
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