[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
IJRR Information::
For Authors::
For Reviewers::
Subscription::
News & Events::
Web Mail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
ISSN
Hard Copy 2322-3243
Online 2345-4229
..
Online Submission
Now you can send your articles to IJRR office using the article submission system.
..

AWT IMAGE

AWT IMAGE

Volume 14, Issue 4 (10-2016)                   Int J Radiat Res 2016, 14(4): 297-303 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Kim H, Phak J, Kim W. Prostate-specific antigen kinetics after hypofractionated stereotactic body radiotherapy for localized prostate cancer. Int J Radiat Res 2016; 14 (4) :297-303
URL: http://ijrr.com/article-1-1814-en.html
Department of Radiation Oncology, Inha University Hospital, Inha University of Medicine, Inchon, Korea
Abstract:   (6973 Views)

Background: stereotactic body radiotherapy (SBRT) has emerged as an effective treatment for localized prostate cancer. However, prostate-specific antigen (PSA) kinetics after SBRT has not been well characterized. The objective of the current study is to analyze the rate of PSA decline and PSA nadir following hypofractonated SBRT in localized prostate cancer. Materials and Methods: From 2008 to 2014, thirty-nine patients newly diagnosed, localized prostate (25.6% low risk, 66.7% intermediate risk and 7.7% high risk) cancer were treated with SBRT using Cyberknife. Total dose of 36.25 Gy in 5 fractions of 7.25 Gy were administered. No one received androgen deprivation therapy (ADT). PSA nadir and rate of change in PSA (slope) were calculated and compared. Results: With a median follow-up of 52 months (range, 13-71), the median rates of decline of PSA were -0.372, -0.211 and -0.128 ng/mL/month, respectively, for durations of 1, 2 and 3 years after radiotherapy, respectively. The decline of PSA was maximal in the first year and continuously decreased for durations of 2 and 3 year. The median PSA nadir was 0.28 ng/mL after a median 33 months. There was one biochemical failure, occurring in a high risk patient. 5-year actuarial biochemical failure (BCF) free survival was 94.2%. Conclusion: In this report of localized prostate cancer, continuous decrease of PSA level for duration 1, 2 and 3 year following SBRT using Cyberknife resulted in lower PSA nadir. Also, SBRT leaded to long-term favorable BCF-free survival.

Full-Text [PDF 659 kb]   (1825 Downloads)    
Type of Study: Short Report | Subject: Radiation Biology

Add your comments about this article : Your username or Email:
CAPTCHA

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

International Journal of Radiation Research
Persian site map - English site map - Created in 0.03 seconds with 50 queries by YEKTAWEB 4718