[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 16, Issue 2 (4-2018) ::
Int J Radiat Res 2018, 16(2): 177-183 Back to browse issues page
Clinical evaluation of simultaneous integrated boost in brain metastasis patients with helical intensity modulated radiotherapy
A. Mayadagli, H.S Kiziltan, I. Kingir Celtik, K. Berk, E. Tekce, A.H. Eris, H. Seyithanoglu
Department of Radiation Oncology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey , alpdag@hotmail.com
Abstract:   (4680 Views)
Background: This study was performed to assess patient survival and treatment toxicity after helical tomotherapy (HT) with simultaneous integrated boost (SIB) radiotherapy (RT) for cancer patients with one to eight brain metastases (BM) who have been treated with or without surgery. Materials and Methods: A total of 48 brain metastasis (BM) patients were included in this retrospective study between April 2015 and December 2016,. The patients were treated with image-guided intensity modulated radiation therapy (IMRT) on the helical tomotherapy (HT) machine. Whole brain HT as 25 Gy and SIB to metastasis sites as 35 Gy was delivered in 10 fractions. The patient were aged between 50 to 80 years old, volume of the BM was between 6 to 75 cc and the number of brain metastasis was between 1 to 8, Karnofsky Performance Score (KPS) ranged between 50-90 and RPA I-III. Surgery was performed to two patients before RT. The maximum patient follow-up time was 20 months.  Results: The primary neurotoxicity observed in patients was grade I- II brain edema related headache and lethargy. In patients who had survived 3- 12 months, KPS improved median score of 20 points and RPA was grade I after six months. Twelve patients had passed away at the end of a 20- month follow-up. Conclusion: HT utilizing SIB treatment for 1- 8 BM was achieved successfully with no significant toxicity. An improvement of performance status indicators of patients following RT was observed.
Keywords: Simultaneous integrated boost, brain metastasis, Tomotherapy, radiotherapy.
Full-Text [PDF 648 kb]   (1493 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
Send email to the article author

Add your comments about this article
Your username or Email:


XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mayadagli A, Kiziltan H, Kingir Celtik I, Berk K, Tekce E, Eris A et al . Clinical evaluation of simultaneous integrated boost in brain metastasis patients with helical intensity modulated radiotherapy . Int J Radiat Res 2018; 16 (2) :177-183
URL: http://ijrr.com/article-1-2233-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 16, Issue 2 (4-2018) Back to browse issues page
International Journal of Radiation Research
Persian site map - English site map - Created in 0.04 seconds with 32 queries by YEKTAWEB 4549