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:: Volume 16, Issue 2 (4-2018) ::
Int J Radiat Res 2018, 16(2): 185-195 Back to browse issues page
Demographic characteristics and prognostic factors in pediatric-type sarcomas; A 7 year single institutional experience and comprehensive review of the current literature
E. Esmati , A. Maddah Safaei Dr. , H. Nosrati , M. Babaei , M. Lashkari , F. Amouzegar Hashemi , F. Farhan , M. Mirai Ashtiani , N. Khanjani , A. Alibakhshi
Department of Radiation Oncology, Cancer Institute, Imam Khomeini Hospital, Keshavarz Blvd, Tehran, Iran , afsan1980@ymail.com
Abstract:   (544 Views)
Background: Due to limited clinical data in pediatric-type sarcomas (rhabdomyosarcoma, Ewing's sarcoma, PNET, and desmoplastic small round-cell tumor), the aim of this study was to evaluate the demographic characteristics and identifying prognostic factors for survival. Materials and Methods: We retrospectively reviewed 110 patients with pediatric-type sarcomas. Overall and disease free survival was analyzed with the Kaplan-Meier method and log rank test. To identify prognostic factors for overall and disease free survival, multivariate survival analyses using a Cox’s proportional-hazard regression model was performed. Results: In this study mean age of patients were 20.30 years (SD=13.61; range, 1–83 years). The survival data of 54 patients (49.1%) were obtained with median survival of 27 months. 3 and 5-year survival rate of these patients were 41.5% and 28.3% respectively. Recurrence of disease (P=0.006) and Ewing sarcoma subtype (P=0.018) were significantly associated with poor overall survival and location of the lesion in the upper extremities (P=0.007) and trunk (P=0.005) were significantly associated with a lower disease free survival. Conclusion: With multivariate analysis, the authors determined that recurrence of disease and Ewing's sarcoma subtype are poor prognostic factors for overall survival and site of origin for disease free survival among patients with pediatric-type sarcoma. In addition, gender, patient's age, and size of tumor had no significant impact on overall and disease free survival.
 
Keywords: Cancer, prognostic factor, sarcoma, small round cell, survival.
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Type of Study: Original Research | Subject: Radiation Biology
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Esmati E, Maddah Safaei A, Nosrati H, Babaei M, Lashkari M, Amouzegar Hashemi F, et al . Demographic characteristics and prognostic factors in pediatric-type sarcomas; A 7 year single institutional experience and comprehensive review of the current literature . Int J Radiat Res. 2018; 16 (2) :185-195
URL: http://ijrr.com/article-1-2234-en.html


Volume 16, Issue 2 (4-2018) Back to browse issues page
International Journal of Radiation Research
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