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Peri-operative radiotherapy for the prevention of post-operative fibrosis on rats
H.S. Kiziltan , A.H. Eris , I. Meral , H. Seyithanoglu , T. Dundar , F. Eren , N. Unver , T. Aydin , A. Mayadagli Dr. , A.G. Bayir , M. Celikten
Department of Radiation Oncology, Bezmialem Vakif University, Faculty of Medical, 34093 Fatih, Istanbul, Turkey , alpdag@hotmail.com
Abstract:   (240 Views)
Background: Post-operative fibrosis related pains and functional anomalies  can be serious problems for patients. Radiotherapy (RT) could inhibit fibrosis which may occurs post- operation especially following laminectomy. Therefore, this study was designed to investigate the effect of peri-operative RT on the prevention of post-operative fibrosis and scar formation on rats. Materials and Methods: Twenty three male Wistar albino rats,  were divided into three experimental groups. Laminectomy was performed to L3 and L4 lomber vertebral regions of group L and L+R rats. The rats in L+R group  in addition to this procedure also received peri-operative RT on the laminectomy area. A total dose of 700 cGy of RT was applied as a single fraction  using electrons. Control rats received no treatment. A rotarod test was performed at 20, 30 and 40 rpm/min speed rates to determine the physical performances of the rats. Results: The results have indicated statistically significant (P<0.05) differences for the 30 rpm/min rotarod test between the L and L+R groups. Histopatologically, significant differences were observed in epidural fibrosis, fibroblast cell density and arachnoid adhesion between the L and L+R groups. Conclusion: It was concluded that peri-operative RT may provide a significant advantage for prevention post-laminectomic of scar tissue formation.
Keywords: Laminectomy, peri-operative radiotherapy, fibrosis, rotarod tests.
Full-Text [PDF 1764 kb]   (17 Downloads)    
Type of Study: Reviews and Perspectives | Subject: Radiation Biology
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International Journal of Radiation Research
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