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:: Volume 17, Issue 1 (1-2019) ::
Int J Radiat Res 2019, 17(1): 57-65 Back to browse issues page
Inhibitory effects of Cheonggukjang extracts on radiation-induced micronucleus formation and inflammasome activation
J.H. Kim, L. Li, D.H. Park, I.W. Lee, N. Ham, H.S. Kim, Y.J. Kim, J. Shim, S.W. Kwon, M.J. Lee PhD
Department of Laboratory Animal Medicine, College of Veterinary Medicine Kangwon National University, Chuncheon, Republic of Korea , mjlee@kangwon.ac.kr
Abstract:   (351 Views)
Background: People are exposed to more radiation than before with the application of radiation technology. Radiation is known to induce damage to cell structure, DNA, chromosomes and nucleus. In this study, we showed that CGJ extract can inhibit radiation-induced chromosomal damage in vivo and NLRP7 inflammasome activation in vitro, suggesting that the compound from CGJ can Be considered as a therapeutic materials to reduce adverse effect inflammation and chromosome aberration during radio-therapy. Materials and methods: In this study the inhibitory effects of Cheonggukjang (CGJ) extract on the radiation-induced micronucleus formation in vivo and the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation in vitro. Results: We observed the prolonged presence of radiation-induced inflammation and its onsecutive damage in hematopoietic tissues after irradiation by examining micronucleus formation in polychromatic erythrocytes. Mouse bone marrow-derived macrophages were used to investigate NLRP3 inflammasome activation. The micronucleus analysis with mouse peripheral polychromatic erythrocytes using acridine orange staining showed a significantly (p<0.05) reduced frequency of micronucleated bone marrow polychromatic erythrocytes (MnPCEs) in CGJ-treated mice. Conclusion: CGJ extract elevated the chance that mice would survive a potentially lethal dose of gamma-irradiation. Additionally, The CGJ extract attenuated IL-1β maturation by interrupting the inflammasome. The CGJ extract attenuates radiation-induced micronucleus formation possibly mediated by inhibiting inflammasome, which provides valuable information for the further study of the mechanism of action of CGJ extract.
Keywords: Cheonggukjang, radiation, micronuclei, inflammasome, NLRP3.
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Type of Study: Original Research | Subject: Radiation Biology
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Kim J, Li L, Park D, Lee I, Ham N, Kim H, et al . Inhibitory effects of Cheonggukjang extracts on radiation-induced micronucleus formation and inflammasome activation . Int J Radiat Res. 2019; 17 (1) :57-65
URL: http://ijrr.com/article-1-2458-en.html


Volume 17, Issue 1 (1-2019) Back to browse issues page
International Journal of Radiation Research
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