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Mathematical description and prognosis of synergistic interaction of radon and tobacco smoking
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J.K. Kim   , S.A. Belkina , V.G. Petin |
| , jkkim@kaeri.re.kr |
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Abstract: (14600 Views) |
Background: Radon and its short-lived decay
products are considered as the important sources of
public exposure to natural radioactivity. The synergistic
interaction between tobacco smoking and radon is
known to be an actual problem. This study has
provided a mathematical description and prognosis of
the carcinogenic effects after combined action of
radon with smoking. Materials and Methods: A
simple mathematical model was adjusted for the
optimization and prognosis of the synergistic
interaction of radon with smoking. The model
postulates that the occurrence of synergism is to be
expected as a result of additional carcinogenic
damage arising from the interaction of sublesions
induced by the two agents under consideration.
Results: The predictions of the model were verified by
comparison with experimental data published by other
researchers. The model appears to be appropriate and
the predictions valid. Conclusion: The suggested
mathematical model predicts the greatest level of
synergistic effect and condition under which this level
is reached. The synergistic effect appeared to decline
with any deviation from the optimal value of the ratio
of carcinogenic effective damages produced by each
agent alone.
Iran. J. Radiat. Res., 2007 4 (4): 169-174 |
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| Keywords: Radon, smoking, synergistic interaction, mathematical model, carcinogenesis. |
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Full-Text [PDF 315 kb]
(2750 Downloads)
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Type of Study: Original Research |
Subject:
Radiation Biology
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