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Radiobiological comparison of 3D conformal and intensity modulated radiation therapy in the treatment of left-sided breast cancer
A. Shanei, A. Amouheidari, I. Abedi Ph.D., , A. Kazemzadeh, A. Jaafari
Faculty Member of Medical Physics Department, Isfahan University of Medical Sciences, Isfahan, Iran , i.abedi@med.mui.ac.ir
Abstract:   (79 Views)
Background: The current study aimed to compare the tumor control probability (TCP) and normal tissue complication probability (NTCP) of three-dimensional conformal radiation therapy (3D-CRT) and intensity-modulated radiation therapy (IMRT) for left-sided breast cancer using radiobiological models. Methods: This study was conducted on 30 patients with left-sided breast cancer, who were planned for 3D-CRT and 6-9 fields IMRT treatments using the PROWESS treatment planning system.  The planning target volume (PTV) dose of 50 Gy was administered for the 3D-CRT and IMRT plans, respectively.  The Niemierko’s equivalent uniform dose (EUD) model was utilized for the estimation of tumor control probability (TCP) and normal tissue complication probability (NTCP). Results: According to the results, the mean TCP values for 3D-CRT, 6-fields IMRT, and 9-fields IMRT plans were 99.07 ±0.07, 99.24 ±0.05 and 99.28 ±0.04, respectively, showing no statistically significant difference. The NTCPs of the lung and heart were considerably lower in the IMRT plans, compared to those in the 3D-CRT plans.
Conclusions: From the radiobiological point of view, our results indicated that 3D-CRT produces a lower NTCP for ipsilateral lung. In contrast, for TCP calculations, there was a higher gain with IMRT plans compared to 3D-CRT plans.
Keywords: Radiobiological evaluation, left-sided breast cancer, three dimensional conformal and intensity-modulated radiation therapy.
Full-Text [PDF 1915 kb]   (16 Downloads)    
Type of Study: Original Research | Subject: Medical Physics
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International Journal of Radiation Research
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