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:: Volume 18, Issue 3 (7-2020) ::
Int J Radiat Res 2020, 18(3): 549-555 Back to browse issues page
Radiosensitization of [Ru(bpy)2(phen)]Cl2 on nasopharyngeal carcinoma cells
J. Chen Ph.D., , Y. Xiao, L. Wu, F. Xiao, Q. Wang, J. Hong, P. Zhu
Department of Radiotherapy, Fujian Medical University Union Hospital, Fuzhou 350001, and the Third Affiliated Hospital, Fujian Medical University, Fuzhou 350108, People's Republic of China , jw_chen18@outlook.com
Abstract:   (140 Views)
Background: To investigate effect of radiosensitization of [Ru(bpy)2(phen)]Cl2 complex on nasopharyngeal carcinoma cell line CNE1 and its mechanism. Materials and Methods: Nasopharyngeal carcinoma cell line CNE1 in vitro culture was divided into control group, light irradiation group (4 Gy, 6 MV photonic line), simple metal ruthenium complex treatment group (Ru group, 100 μmol/L [Ru(bpy)2(phen)]Cl2) and metal ruthenium complex combined with radiotherapy group (Combined radiotherapy group, cells were irradiated with 4 Gy and 6 MV photons at 2 days after 100 μmol/L [Ru(bpy)2(phen)]Cl2). Results: Transcriptional level of P53 gene in combined radiotherapy group was higher than that in the other groups (P<0.001). Inhibition rate of combined radiotherapy group was higher than that of Ru group and irradiation group (P<0.001). Apoptotic rate was the highest (P<0.05) in the combined radiotherapy group, and irradiation group was higher than Ru group and control group (P<0.05). Survival rate of Ru group was lower than that of control group under the same radiation dose (P<0.05), and the radiotherapy sensitization ratio was 1.227 (Dq ratio). Conclusion: [Ru(bpy)2(phen)]Cl2 increases the sensitivity of nasopharyngeal carcinoma cell line CNE1 to X-ray, which may be related to increase of P53 gene expression.
Keywords: [Ru(bpy)2(phen)]Cl2, nasopharyngeal carcinoma cells, P53 gene, radiosensitization.
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Type of Study: Original Research | Subject: Radiation Biology
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Chen J, Xiao Y, Wu L, Xiao F, Wang Q, Hong J et al . Radiosensitization of [Ru(bpy)2(phen)]Cl2 on nasopharyngeal carcinoma cells. Int J Radiat Res. 2020; 18 (3) :549-555
URL: http://ijrr.com/article-1-3075-en.html


Volume 18, Issue 3 (7-2020) Back to browse issues page
International Journal of Radiation Research
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