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:: Volume 18, Issue 3 (7-2020) ::
Int J Radiat Res 2020, 18(3): 593-598 Back to browse issues page
Changes in the radiochemical purity of [18F]FDG radiopharmaceutical according to the amount of ethanol added
S. Kim Ph.D., , E. Han Ph.D.,
Department of Cyclotron Center of Nuclear Medicine, CareCamp Inc, Daegu 42415, Korea , stkim@carecamp.com
Abstract:   (106 Views)
Background: we aimed to find the optimal level of ethanol that can be added such that the radiochemical purity of [18F]FDG is increased and the MFDS and USP stipulated guidelines are met. Materials and Methods: Changes in the radiochemical purity of [18F]FDG were analyzed according to changes in the concentrations of ethanol added. The study used 1 L of 99.9% pure ethanol. The ethanol concentrations used were 0.0% (0 µL) for the control group and 0.1% (1 µL), 0.2% (2 µL), and 0.3% (3 µL) for the experimental groups. Since the radiochemical purity of [18F]FDG may differ according to the radioactive concentrations used, four different radioactive concentrations were prepared: 1580 mCi/16 mL, 3320 mCi/16 mL, 4840 mCi/16 mL, and 6470 mCi/16 mL. Results: The radiochemical purity of [18F]FDG increased significantly when ethanol was added to it at different radioactive concentrations in comparison to when ethanol was not added. When ethanol concentrations of 0.1%, 0.2%, and 0.3% were added, the radiochemical purity increased at all radioactive concentrations (100 mCi/mL, 200 mCi/mL, 300 mCi/mL, and 400 mCi/mL) while meeting the KP and USP standards even after 10 hours following the EOS. Conclusion: It was determined in our study that adding ethanol at the concentration of 0.1% to [18F]FDG is most suitable as it generates the least residual ethanol while maintaining the radiochemical purity of [18F]FDG at stable levels that meet the KP and USP standards.
Keywords: [18F]FDG, ethanol, radiochemical purity, radiopharmaceutical, US pharmacopeia, Korean pharmacopeia
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Type of Study: Technical Note | Subject: Medical Physics
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Kim S, Han E. Changes in the radiochemical purity of [18F]FDG radiopharmaceutical according to the amount of ethanol added. Int J Radiat Res. 2020; 18 (3) :593-598
URL: http://ijrr.com/article-1-3095-en.html

Volume 18, Issue 3 (7-2020) Back to browse issues page
International Journal of Radiation Research
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