[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
IJRR Information::
For Authors::
For Reviewers::
Subscription::
News & Events::
Web Mail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
ISSN
Hard Copy 2322-3243
Online 2345-4229
..
Online Submission
Now you can send your articles to IJRR office using the article submission system.
..

AWT IMAGE

AWT IMAGE

Volume 19, Issue 4 (10-2021)                   Int J Radiat Res 2021, 19(4): 891-898 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Guo J, Yang Y. Synuclein-γ Polymorphisms and radiotherapy for breast cancer: a retrospective study. Int J Radiat Res 2021; 19 (4) :891-898
URL: http://ijrr.com/article-1-3965-en.html
General Medical Practice, Baoding First Central Hospital, Baoding, 071000, China , yangyingbochina@163.com
Abstract:   (2122 Views)
Background: Synuclein γ (SNCG), a member of the brain protein synuclein family, is highly expressed in pervasive human breast carcinoma and was associated with poor outcomes in radiotherapy treatment. So, the present study was conducted to assess the C243G and A377T polymorphisms of this gene in relationship with the success of radiotherapy. Materials and Methods:
In this retrospective study, 114 patients who had undergone a radical modified mastectomy and referred for radiation therapy were studied. Genomic DNA was extracted from peripheral blood cells. Genotyping was done for C243G and A377T polymorphisms. Differences in allele or genotype frequencies were evaluated. Results: The median overall Survival (OS) Rate of all patients was 44 months (IQR: 5.09). Genotyping the patients, there were 25 (%) GG, 34 (%) CG, and 55 (%) CC patients for exon 3 polymorphism (C243G). Comparison of three genotypes effect on OS was not significant (X2(2) =2.25, P=0.323). Hazard Ratio of CC vs. GG was 1.042 (95%CI:0.5360- 2.027), which was not statistically significant. There were 60 (%) AA, 37 (%) AT, and 17 (%) TT patients for exon 4 polymorphism (A377T). Comparison of three genotypes effect on OS was not significant (X2(2) =0.441, P=0.802). Comparing only patients with AA and TT genotypes, Hazard Ratio of AA vs. TT was 1.26 (95%CI:0.5123-3.118), which was not statistically significant. Conclusion: There is a possibility of the role of GG and TT genotypes as a genetic risk factor in breast cancer which should be evaluated in a study with higher sample size.
Full-Text [PDF 1650 kb]   (886 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

International Journal of Radiation Research
Persian site map - English site map - Created in 0.03 seconds with 50 queries by YEKTAWEB 4718