[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
IJRR Information::
For Authors::
For Reviewers::
Subscription::
News & Events::
Web Mail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
ISSN
Hard Copy 2322-3243
Online 2345-4229
..
Online Submission
Now you can send your articles to IJRR office using the article submission system.
..

AWT IMAGE

AWT IMAGE

Volume 19, Issue 4 (10-2021)                   Int J Radiat Res 2021, 19(4): 913-920 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Moghimi Y, Banaei A, Majdaeen M, Zamani H, Abedi-Firouzjah R. Radiation protection and cytotoxicity effects of different concentrations of cerium oxide nanoparticles in aqueous solution combined with sodium dodecyl sulphate in Vero cells irradiated with 18 MV beams. Int J Radiat Res 2021; 19 (4) :913-920
URL: http://ijrr.com/article-1-3970-en.html
Department of Radiotherapy and Oncology, Razi Hospital, Rasht, Iran , Mehrsa.majdaeen@yahoo.com,
Abstract:   (2584 Views)
Background: This study aimed to assess and compare the radioprotective and cytotoxic effects of various concentrations of cerium oxide nanoparticles (CONPs) in aqueous solution combined with sodium dodecyl sulphate (SDS) against high energy X-ray beams in Vero cells. Materials and Methods: The scanner electron microscopy (SEM) method was used to analyze the properties of CONPs. The cells were incubated with different concentrations of CONPs in aqueous solution combined with SDS. The non-toxic CONPs concentrations in Vero normal cells were determined using MTT assay. The cell’s uptake was measured by an UV/VIS absorption spectrophotometry. The cells were irradiated with different doses of 18 MV photon (1, 2, and 3 Gy), and their viabilities at various concentrations were measured to evaluate the radiation protection effects of CONPs. Results: The CONPs concentrations lower than 600 μg/ml were referred as non-toxic effects regarding MTT results. The 600 μg/ml was regarded as the highest radioprotection effect among the non-toxic concentrations (P-value˂0.05). The average percentage of cell viability improvement was estimated as 17, 23.61, and 27.21% for 1, 2, and 3 Gy doses, respectively, compared to the control group (with no CONPs). Pearson’s correlation coefficients between the CONPs concentration and cell viability were obtained as 0.96, 0.99, and 0.99 for 1, 2, and 3 Gy doses, respectively; showing that the increased concentration leads to an increase in higher radioprotection. Conclusion: The 600 μg/ml of CONPs aqueous solution combined with SDS, as a stable non-toxic concentration, has the highest radiation protection effect when exposed to high-energy photon beams. So, this concentration can be considered as an appropriate candidate of radioprotection for further research.
Full-Text [PDF 1994 kb]   (977 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

International Journal of Radiation Research
Persian site map - English site map - Created in 0.05 seconds with 50 queries by YEKTAWEB 4718