[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 20, Issue 3 (7-2022) ::
Int J Radiat Res 2022, 20(3): 555-561 Back to browse issues page
Efficacy of Hematoporphyrin mediated photo-sonodynamic therapy on mice breast cancer
S. Moshfegh, M. Jadidi, H. Hasanzadeh, R. Nasr, M. Mirmohammadkhani
Department of Medical Physics, Semnan University of Medical Sciences, Semnan, Iran , Jadidim@semums.ac.ir
Abstract:   (490 Views)
Background: A combination of photodynamic and sonodynamic therapy (PSDT) may be a non-invasive method for cancer treatment, which incorporates a combination of low-intensity ultrasound, laser radiation, and a sensitizer agent. The goal of this research was to evaluate the effect of PSDT with Hematoporphyrin-encapsulated Mesoporous silica nanoparticles (HP-MSNs) as a sensitizer in the management of mice breast adenocarcinoma. Materials and Methods: One hundred and fifty-six female mice (tumor grafted) were separated into 26 groups; including sham, laser (650 nm), 4 groups of laser + HP or MSN-HP (2.5 and 5 mg/kg), 4 groups of laser + ultrasound (1and 3 MHz; 1, 2 W/cm2), 16 groups of PSDT + HP or HP-MSN. The tumor growth factors were used to assess the procedure findings. Results: The results indicate that PSDT with an injection of HP or HP-MSN is effective in delaying tumor growth (P<0.05). Overall comparison of data showed a non-significant difference between PSDT with HP-MSN groups. The time of T2 and T5 in the groups of PSDT with HP-MSN were increased in comparison with sham and that of PSDT with HP groups (P<0.05). The tumor growth inhibition ratio increased in all PSDT groups. This increase was transient and declined over 30 days of treatment. PSDT + HP-MSN had Grade I, while other groups had Grade III malignancy in the histological study. Conclusion: The research gave profound findings involving the employ of PSDT with HP-MSN as a photo/sonosensitizer for treating breast adenocarcinoma implanted in mice.
Keywords: Photodynamic therapy, sonodynamic therapy, laser, ultrasound, breast cancer.
Full-Text [PDF 2609 kb]   (305 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
Send email to the article author

Add your comments about this article
Your username or Email:


XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Moshfegh S, Jadidi M, Hasanzadeh H, Nasr R, Mirmohammadkhani M. Efficacy of Hematoporphyrin mediated photo-sonodynamic therapy on mice breast cancer. Int J Radiat Res 2022; 20 (3) :555-561
URL: http://ijrr.com/article-1-4325-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 20, Issue 3 (7-2022) Back to browse issues page
International Journal of Radiation Research
Persian site map - English site map - Created in 0.04 seconds with 32 queries by YEKTAWEB 4570