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Prophylactic irradiation meta-analysis in reducing procedure tract metastasis incidence in malignant pleural mesothelioma
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| H-F Chen, C-W Xu, W-X Wang, L-C Huang, P-E Chen, X-F Li, G. Lan, Z-Q Zhai, Y-C Zhu, K-Q Du, M-Y Fang |
| Department of Thoracic Disease Center, Zhejiang Rongjun Hospital, Jiaxing Zhejiang 314000, People's Republic of China , 918576941@qq.com |
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Abstract: (321 Views) |
Background: Malignant pleural mesothelioma (MPM) diagnoses are primarily based on pleural biopsy. Invasive procedures may result in iatrogenic dissemination of tumor cells along the subcutaneous channels. The purpose of our study was to clarify the effect of prophylactic radiotherapy on the incidence of metastasis in patients afflicted with MPM. Materials and Methods: Relevant studies were searched in PubMed, Cochrane Library, and Embase databases from the establishment of the library to February 2022. The quality of the included studies was evaluated, and the data were statistically analyzed. Results: Seven articles were obtained, and 1030 patients were included in the study, which allowed comparison of the procedure to track metastases (PTMs) incidences between radiotherapy and control groups. The results revealed statistically significant differences in the incidence of PTMs between the two groups (OR=0.48, 95% confidence interval [CI]:0.33, 0.69, p<0.0001). Subgroup analysis further showed that preventive radiotherapy could effectively reduce the incidence of PTMs in MPM patients who underwent large-caliber invasive procedures but could not reduce the incidence of PTMs after small-caliber invasive procedures. Prophylactic radiotherapy in patients with epithelial PTM types could reduce the incidence (OR=0.27, 95% CI:0.11, 0.69, P=0.006). Conclusion: Prophylactic radiotherapy is safe and can effectively prevent the occurrence of iatrogenic PTMs in patients with epithelial MPM who have undergone thoracotomy, thoracoscopy, indwelling chest wall drainage tubes, and other large-caliber operations. |
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| Keywords: Malignant pleural mesothelioma, prophylactic irradiation, procedure tract metastases. |
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Full-Text [PDF 804 kb]
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Type of Study: Review article |
Subject:
Radiation Biology
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