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:: Volume 21, Issue 4 (10-2023) ::
Int J Radiat Res 2023, 21(4): 621-625 Back to browse issues page
Computerized tomography diagnosis of pulmonary fungal infection in patients with acute leukemia after chemotherapy
D. Kong , J. Guo , Q. Li , J. Liu , L. Song
Department of Hematology, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, China , songlixiao510@126.com
Abstract:   (809 Views)
Background: To explore computerized tomography (CT) imaging features of pulmonary fungal infection (PFI) in patients with acute leukemia (AL) after chemotherapy. Materials and Methods: Totally 116 AL patients who received chemotherapy in our hospital from June 2016 to April 2023 participated into this study, and the pulmonary fungal infection was confirmed by laboratory examination and clinical antifungal treatment. The CT image signs, lesion distribution, CT concomitant signs and main types of fungal infection were analyzed. Results: CT image signs of two main types, nodule/mass type and mixed type were recorded, with76 cases of nodular/mass type and 40 cases of mixed type. There were 372 lesions in nodules/mass cases, mainly in the upper lung (46.24%). In these 372 lesions, 113 micro-tubercle, 138 small nodules, 115 nodules and 6 masses were included. There were 88 cases of halo sign, 26 cases of cavity, and 25 cases of air crescent sign. Candida albicans was the most common pathogenic fungal strain, followed by aspergillus, candida tropicalis, candida glabrata, candida parapsilosis, cryptococcus, candida dubliniensis, mucor, candida krusei and candida rugosa. Conclusion: The CT manifestations of AL complicated with pulmonary fungal infection after chemotherapy were various, most of which had no characteristics, but the “halo sign” and “air crescent sign” had certain specificity. The combined CT and clinical manifestations can narrow the range of differential diagnosis. When the diagnosis still cannot be confirmed, diagnostic therapy or early diagnosis by fungal culture and histological examination can be performed.
Keywords: Pulmonary fungal infection, acute leukemia, chemotherapy, computerized tomography.
Full-Text [PDF 572 kb]   (403 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
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Kong D, Guo J, Li Q, Liu J, Song L. Computerized tomography diagnosis of pulmonary fungal infection in patients with acute leukemia after chemotherapy. Int J Radiat Res 2023; 21 (4) :621-625
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Volume 21, Issue 4 (10-2023) Back to browse issues page
International Journal of Radiation Research
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