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:: Volume 21, Issue 4 (10-2023) ::
Int J Radiat Res 2023, 21(4): 693-698 Back to browse issues page
The role of FDG uptake to predict the need for re-irradiation in patients treated with 8 Gy (X-ray) single fraction palliative radiotherapy for bone metastases
A. Kuzhan , M. Adli
Department of Radiation Oncology, Pamukkale University, Denizli, Turkey , a_kuzhan46@hotmail.com
Abstract:   (1170 Views)
Background: The study aims to evaluate the relationship between the maximum standardized uptake value (SUVmax) of fluorodeoxyglucose positron emission tomography (FDG-PET) before radiation therapy (RT) and the further need for re-irradiation (re-RT) in patients with bone metastases (BM), and to predict the complete response using pre-treatment SUVmax. Materials and Methods: Fifty-three patients with 133 painful BMs were accepted into the study. Pain scores and SUVmax at painful BM were recorded. Eight Gray in single fraction palliative RT was administered to all of the patients. A total of 7 patients (8 osseous lesions) underwent re-RT.  Factors associated with re-RT were analyzed using Cox regression analysis. Results: The ideal SUVmax cut-off to predict complete response was 7.95. Median SUVmax was 12.75 (±4.1) and 7 (±3.36) in patients who required re-RT due to pain progression and in those who did not, respectively (p<0.001). Conclusion: FDG uptake may be predictive of the need for re-RT in patients with painful BM. This may impact decisions with single-fraction RT which is associated with higher rates of partial response and further need for re-RT at the same location in patients with high SUVmax. Pre-treatment FDG uptake also may be useful in predicting a complete response.
Keywords: Bone metastasis, FDG uptake, re-irradiation.
Full-Text [PDF 669 kb]   (675 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
References
1. 1. Falkmer U, Jarhult J, Wersall P, Cavallin-Stahl E (2003) A systematic overview of radiation therapy effects in skeletal metastases. Acta Oncol, 42(5-6): 620-33. [DOI:10.1080/02841860310014895] [PMID]
2. Lutz S, Berk L, Chang E, et al. (2011) Palliative radiotherapy for bone metastases: an ASTRO evidence-based guideline. Int J Radiat Oncol Biol Phys, 79(4): 965-76. [DOI:10.1016/j.ijrobp.2010.11.026] [PMID]
3. Na F, Wang J, Li C, et al. (2014) Primary tumor standardized uptake value measured on F18-Fluorodeoxyglucose positron emission tomography is of prediction value for survival and local control in non-small-cell lung cancer receiving radiotherapy: meta-analysis. J Thorac Oncol, 9(6): 834-42. [DOI:10.1097/JTO.0000000000000185] [PMID] []
4. Higgins KA, Hoang JK, Roach MC, et al. (2012) Analysis of pretreatment FDG-PET SUV parameters in head-and-neck cancer: tumor SUVmean has superior prognostic value. Int J Radiat Oncol Biol Phys, 82(2): 548-53. [DOI:10.1016/j.ijrobp.2010.11.050] [PMID]
5. Rodríguez-Fraile M, Cózar-Santiago MP, Sabaté-Llobera A, et al. (2020) FDG PET/CT in colorectal cancer. Rev Esp Med Nucl Imagen Mol (Engl Ed), 39(1): 57-66. [DOI:10.1016/j.remnie.2019.12.001]
6. Kim N, Cho H, Yun M, et al. (2019) Prognostic values of mid-radiotherapy 18F-FDG PET/CT in patients with esophageal cancer. Radiat Oncol, 14(1): 27. [DOI:10.1186/s13014-019-1232-1] [PMID] []
7. Han S, Kim H, Kim YJ, et al. (2018) Prognostic value of volume-based metabolic parameters of 18F-FDG PET/CT in uterine cervical cancer: A systematic review and meta-analysis. AJR Am J Roentgenol, 211(5): 1112-1121. [DOI:10.2214/AJR.18.19734] [PMID]
8. Zhao F, Ding G, Huang W, et al. (2015) FDG-PET predicts pain response and local control in palliative radiotherapy with or without systemic treatment in patients with bone metastasis from non-small-cell lung cancer. Clin Lung Cancer, 16(6): e111-9. [DOI:10.1016/j.cllc.2015.01.005] [PMID]
9. Choi SH, Chang JS, Jeong YH, et al. (2014) FDG-PET predicts outcomes of treated bone metastasis following palliative radiotherapy in patients with hepatocellular carcinoma. Liver Int, 34(7): 1118-25. [DOI:10.1111/liv.12487] [PMID]
10. Tateishi U, Gamez C, Dawood S, et al. (2008) Bone metastases in patients with metastatic breast cancer: morphologic and metabolic monitoring of response to systemic therapy with integrated PET/CT. Radiology, 247(1): 189-96. [DOI:10.1148/radiol.2471070567] [PMID]
11. Tahara T, Fujii S, Ogawa T, et al. (2016) Fluorodeoxyglucose uptake on positron emission tomography is a useful predictor of long-term pain control after palliative radiation therapy in patients with painful bone metastases: Results of a single-institute prospective study. Int J Radiat Oncol Biol Phys, 94(2): 322-8. [DOI:10.1016/j.ijrobp.2015.10.036] [PMID]
12. Adli M, Kuzhan A, Alkis H, et al. (2013) FDG PET uptake as a predictor of pain response in palliative radiation therapy in patients with bone metastasis. Radiology, 269(3): 850-6. [DOI:10.1148/radiol.13121981] [PMID]
13. Delbeke D, Coleman RE, Guiberteau MJ, et al. (2006) Procedure guideline for tumor imaging with 18F-FDG PET/CT 1.0. J Nucl Med, 47(5): 885-95.
14. Chow E, Hoskin P, Mitera G, et al. (2012) Update of the international consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases. Int J Radiat Oncol Biol Phys, 82(5):1730-7. [DOI:10.1016/j.ijrobp.2011.02.008] [PMID]
15. Li C, Lan X, Yuan H, et al. (2014) 18F-FDG PET predicts pathological response to preoperative chemoradiotherapy in patients with primary rectal cancer: a meta-analysis. Ann Nucl Med, 28(5): 436-46. [DOI:10.1007/s12149-014-0837-6] [PMID]
16. Yoshioka M, Sato T, Furuya T, et al. (2004) Role of positron emission tomography with 2-deoxy-2-[18F]fluoro-D-glucose in evaluating the effects of arterial infusion chemotherapy and radiotherapy on pancreatic cancer. J Gastroenterol, 39(1): 50-5. [DOI:10.1007/s00535-003-1244-2] [PMID]
17. Borst GR, Belderbos JS, Boellaard R, et al. (2005) Standardised FDG uptake: a prognostic factor for inoperable non-small cell lung cancer. Eur J Cancer, 41(11): 1533-41. [DOI:10.1016/j.ejca.2005.03.026] [PMID]
18. Yao M, Smith RB, Graham MM, et al. (2005) The role of FDG PET in management of neck metastasis from head-and-neck cancer after definitive radiation treatment. Int J Radiat Oncol Biol Phys, 63(4): 991-9. [DOI:10.1016/j.ijrobp.2005.03.066] [PMID]
19. Allal AS, Slosman DO, Kebdani T, et al. (2004) Prediction of outcome in head-and-neck cancer patients using the standardized uptake value of 2-[18F]fluoro-2-deoxy-D-glucose. Int J Radiat Oncol Biol Phys, 59(5):1295-300. [DOI:10.1016/j.ijrobp.2003.12.039] [PMID]
20. Calais J, Thureau S, Dubray B, et al. (2015) Areas of high 18F-FDG uptake on preradiotherapy PET/CT identify preferential sites of local relapse after chemoradiotherapy for non-small cell lung cancer. J Nucl Med, 56(2):196-203. [DOI:10.2967/jnumed.114.144253] [PMID]
21. Xiao W, Xu A, Han F, et al. (2015) Positron emission tomography-computed tomography before treatment is highly prognostic of distant metastasis in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy treatment: a prospective study with long-term follow-up. Oral Oncol, 51(4): 363-9. [DOI:10.1016/j.oraloncology.2015.01.009] [PMID]
22. Mizumoto M, Harada H, Asakura H, et al. (2008) Prognostic factors and a scoring system for survival after radiotherapy for metastases to the spinal column: a review of 544 patients at Shizuoka Cancer Center Hospital. Cancer, 113(10): 2816-22. [DOI:10.1002/cncr.23888] [PMID]
23. Choi Y, Kim J, Lee I, Seong J (2014) Dose escalation using helical tomotherapy improves local control in spine metastases from primary hepatic malignancies. Liver Int, 34(3): 462-8. [DOI:10.1111/liv.12260] [PMID]
24. Yamada Y, Bilsky MH, Lovelock DM, et al. (2008) High-dose, single-fraction image-guided intensity-modulated radiotherapy for metastatic spinal lesions. Int J Radiat Oncol Biol Phys, 71(2): 484-90. [DOI:10.1016/j.ijrobp.2007.11.046] [PMID]
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Kuzhan A, Adli M. The role of FDG uptake to predict the need for re-irradiation in patients treated with 8 Gy (X-ray) single fraction palliative radiotherapy for bone metastases. Int J Radiat Res 2023; 21 (4) :693-698
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Volume 21, Issue 4 (10-2023) Back to browse issues page
International Journal of Radiation Research
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