[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
IJRR Information::
For Authors::
For Reviewers::
Subscription::
News & Events::
Web Mail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
ISSN
Hard Copy 2322-3243
Online 2345-4229
..
Online Submission
Now you can send your articles to IJRR office using the article submission system.
..

AWT IMAGE

AWT IMAGE

:: Volume 21, Issue 4 (10-2023) ::
Int J Radiat Res 2023, 21(4): 751-755 Back to browse issues page
Application of magnetic resonance quantitative technique to calculate liver iron concentration in the diagnosis and efficacy evaluation of transfusion-related iron overload
Y. Niu , Y. Xia , S. Zhu , X. Zhang
Department of Hematology, The First People’s Hospital of Lanzhou City, Lanzhou, Gansu 730050, China , ZhangXL9258@163.com
Abstract:   (597 Views)
Background: To explore the diagnosis and evaluation efficacy of liver iron concentration (LIC) based on magnetic resonance quantitative technique in liver iron overload in patients with long-term transfusion. Materials and Methods: From November 2021 to January 2023, 30 chronic aplastic anemia (CAA) patients with long-term blood transfusion admitted to our hospital were included as the study group. Simultaneously, 20 healthy volunteers with matched gender and age were included in the control group. The serum ferritin (SF), serum iron, total iron binding capacity and transferrin saturation (TSAT) between the two groups was calculated and compared. LIC was evaluated using Liver Magnetic resonance imaging (MRI)-R2* map imaging. The correlation between LIC and SF and TSAT was analyzed, and the diagnosis value of LIC in hepatic iron overload was calculated. Low-risk patients (n=22) diagnosed with iron overload received continuous regular iron removal treatment and the SF, TSAT and LIC were measured after 6 months. Results: SF, TSAT and LIC were higher in CAA patients relative to the healthy controls (P<0.05). LIC was positively correlated with SF (r=0.74, P<0.001) and TSAT (r=0.67, P<0.001). The sensitivity and specificity of LIC in the diagnosis of hepatic iron overload were 80.00% and 100% based on SF, and 76.0% and 100% based on TSAT, respectively. Additionally, SF, TSAT and LIC were all declined after 6 months of treatment (P<0.05). Conclusion: The detection of LIC based on MRI-R2* is an effective and non-invasive means for the assessment of liver iron load in patients with long-term transfusion.
Keywords: Magnetic resonance imaging, blood transfusion, aplastic anemia, iron overload.
Full-Text [PDF 605 kb]   (414 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
References
1. 1. Bacigalupo A and Benintende G (2021) Bone marrow transplantation for acquired aplastic anemia: What's new. Best Pract Res Clin Haematol, 34(2): 101284. [DOI:10.1016/j.beha.2021.101284] [PMID]
2. Young NS, Bacigalupo A, Marsh JC (2010) Aplastic anemia: pathophysiology and treatment. Biol Blood Marrow Transplant, 16(1 Suppl): S119-25. [DOI:10.1016/j.bbmt.2009.09.013] [PMID] []
3. Furlong E and Carter T (2020) Aplastic anaemia: Current concepts in diagnosis and management. J Paediatr Child Health, 56(7): 1023-8. [DOI:10.1111/jpc.14996] [PMID]
4. Ye L, Zhang F, Kojima S (2020) Current insights into the treatments of severe aplastic anemia in China. Int J Hematol, 112(3): 292-9. [DOI:10.1007/s12185-020-02955-1] [PMID]
5. Yang W, Zhao X, He G, et al. (2022) Iron chelation of hetrombopag in aplastic anemia: a post hoc analysis of a phase II study. Ann Hematol, 101(12): 2611-6. [DOI:10.1007/s00277-022-04968-8] [PMID]
6. Cheong JW, Kim HJ, Lee KH, et al. (2014) Deferasirox improves hematologic and hepatic function with effective reduction of serum ferritin and liver iron concentration in transfusional iron overload patients with myelodysplastic syndrome or aplastic anemia. Transfusion, 54(6): 1542-51. [DOI:10.1111/trf.12507] [PMID]
7. Pan T, Ji Y, Liu H, et al. (2023) Impact of Iron Overload and Iron Chelation with Deferasirox on Outcomes of Patients with Severe Aplastic Anemia after Allogeneic Hematopoietic Stem Cell Transplantation. Transplant Cell Ther. [DOI:10.1016/j.jtct.2023.04.016] [PMID]
8. Labranche R, Gilbert G, Cerny M, et al. (2018) Liver Iron Quantification with MR Imaging: A Primer for Radiologists. Radiographics, 38(2): 392-412. [DOI:10.1148/rg.2018170079] [PMID]
9. Ghoti H, Rachmilewitz EA, Simon-Lopez R, et al. (2012) Evidence for tissue iron overload in long-term hemodialysis patients and the impact of withdrawing parenteral iron. Eur J Haematol, 89(1): 87-93. [DOI:10.1111/j.1600-0609.2012.01783.x] [PMID]
10. Zimmerman MJ, Rosing DR, Shizukuda Y (2021) Advancement of echocardiography for surveillance of iron overload cardiomyopathy: comparison to cardiac magnetic resonance imaging. J Echocardiogr, 19(3): 141-9. [DOI:10.1007/s12574-021-00524-x] [PMID]
11. Sheth S, Allen CJ, Farrell DE, et al. (2019) Measurement of the liver iron concentration in transfusional iron overload by MRI R2* and by high-transition-temperature superconducting magnetic susceptometry. Clin Imaging, 55: 65-70. [DOI:10.1016/j.clinimag.2019.01.012] [PMID] []
12. Killick SB, Bown N, Cavenagh J, et al. (2016) Guidelines for the diagnosis and management of adult aplastic anaemia. Br J Haematol, 172(2): 187-207. [DOI:10.1111/bjh.13853] [PMID]
13. Wu D, Wen X, Liu W, et al. (2018) A composite mouse model of aplastic anemia complicated with iron overload. Exp Ther Med, 15(2): 1449-55. [DOI:10.3892/etm.2017.5523]
14. Yang L, Wang H, Yang X, et al. (2020) Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms. Signal Transduct Target Ther, 5(1): 138. [DOI:10.1038/s41392-020-00253-0] [PMID] []
15. Li LX, Guo FF, Liu H, et al. (2022) Iron overload in alcoholic liver disease: underlying mechanisms, detrimental effects, and potential therapeutic targets. Cell Mol Life Sci, 79(4): 201. [DOI:10.1007/s00018-022-04239-9] [PMID]
16. Hilken A, Langebrake C, Wolschke C, et al. (2017) Impact of non-transferrin-bound iron (NTBI) in comparison to serum ferritin on outcome after allogeneic stem cell transplantation (ASCT). Ann Hematol, 96(8): 1379-88. [DOI:10.1007/s00277-017-3034-6] [PMID]
17. Zhang X, Shi Y, Huang Y, et al. (2018) Serum ferritin is a different predictor from transfusion history for allogeneic transplantation outcome in patients with severe aplastic anemia. Hematology, 23(5): 291-8. [DOI:10.1080/10245332.2017.1390929] [PMID]
18. Chen CH, Shu KH, Yang Y (2015) Long-term effects of an oral iron chelator, deferasirox, in hemodialysis patients with iron overload. Hematology, 20(5): 304-10. [DOI:10.1179/1607845414Y.0000000199] [PMID]
19. Teawtrakul N, Sirijerachai C, Chansung K, et al. (2021) The serum ferritin levels and liver iron concentrations in patients with alpha-thalassemia: is there a good correlation? Hematology, 26(1): 473-7. [DOI:10.1080/16078454.2021.1943829] [PMID]
20. Kell DB and Pretorius E (2014) Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells. Metallomics, 6(4): 748-73. [DOI:10.1039/C3MT00347G] [PMID]
21. Atmakusuma TD, Kalwani R, Nasution SA, et al. (2021) Correlation of Serum Ferritin and Cardiac Iron Toxicity with Cardiac Function in Transfusion Dependent Beta-Thalassemia Major Patients. Acta Med Indones, 53(3): 291-8.
22. Elsayed ME, Sharif MU, Stack AG (2016) Transferrin Saturation: A Body Iron Biomarker. Adv Clin Chem, 75: 71-97. [DOI:10.1016/bs.acc.2016.03.002] [PMID]
23. Peyrin-Biroulet L, Williet N, Cacoub P (2015) Guidelines on the diagnosis and treatment of iron deficiency across indications: a systematic review. Am J Clin Nutr, 102(6): 1585-94. [DOI:10.3945/ajcn.114.103366] [PMID]
24. Khalifa A and Rockey DC (2020) The utility of liver biopsy in 2020. Curr Opin Gastroenterol, 36(3): 184-91. [DOI:10.1097/MOG.0000000000000621] [PMID]
25. Rockey DC, Caldwell SH, Goodman ZD, et al. (2009) Liver biopsy. Hepatology, 49(3): 1017-44. [DOI:10.1002/hep.22742] [PMID]
26. Golfeyz S, Lewis S, Weisberg IS (2018) Hemochromatosis: pathophysiology, evaluation, and management of hepatic iron overload with a focus on MRI. Expert Rev Gastroenterol Hepatol, 12(8): 767-78. [DOI:10.1080/17474124.2018.1496016] [PMID]
27. Reeder SB, Yokoo T, França M, et al. (2023) Quantification of Liver Iron Overload with MRI: Review and Guidelines from the ESGAR and SAR. Radiology, 307(1): e221856. [DOI:10.1148/radiol.221856] [PMID]
28. Campbell-Washburn AE, Mancini C, Conrey A, et al. (2022) Evaluation of Hepatic Iron Overload Using a Contemporary 0.55 T MRI System. J Magn Reson Imaging, 55(6): 1855-63. [DOI:10.1002/jmri.27950] [PMID] []
29. Chapchap EC, Silva MMA, de Assis RA, et al. (2023) Cardiac iron overload evaluation in thalassaemic patients using R2* magnetic resonance imaging following chelation therapy: a multicentre cross-sectional study. Hematol Transfus Cell Ther, 45(1): 7-15. [DOI:10.1016/j.htct.2021.01.014] [PMID] []
30. Wood JC, Enriquez C, Ghugre N, et al. (2005) MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood, 106(4): 1460-5. [DOI:10.1182/blood-2004-10-3982] [PMID] []
31. Nashwan AJ, Yassin MA, Mohamed Ibrahim MI, et al. (2022) Iron Overload in Chronic Kidney Disease: Less Ferritin, More T2(*)MRI. Front Med (Lausanne), 9: 865669. [DOI:10.3389/fmed.2022.865669] [PMID] []
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Niu Y, Xia Y, Zhu S, Zhang X. Application of magnetic resonance quantitative technique to calculate liver iron concentration in the diagnosis and efficacy evaluation of transfusion-related iron overload. Int J Radiat Res 2023; 21 (4) :751-755
URL: http://ijrr.com/article-1-5062-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 21, Issue 4 (10-2023) Back to browse issues page
International Journal of Radiation Research
Persian site map - English site map - Created in 0.05 seconds with 50 queries by YEKTAWEB 4652