1. Peter K, Kar SK, Gothalwal R, et al. (2021) Curcumin in combination with other adjunct therapies for brain tumor treatment: Existing knowledge and blueprint for future research. International Journal of Molecular and Cellular Medicine, 10(3): 163-181.

2. Sung H, Ferlay J, Siegel RL, et al. (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 71: 209-49. [DOI:10.3322/caac.21660]

3. Sigmond J, Honeywell R, Postma T, et al. (2009) Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer. Annals of Oncology, 20(1): 182-187. [DOI:10.1093/annonc/mdn543]

4. Liu Y, Song X, Wu M, et al. (2020) Synergistic efffects of resveratrol and temozolomide against glioblastoma cells: underlying mechanism and therapeutic implications. Cancer Manag Res, 12: 8341-8354. [DOI:10.2147/CMAR.S258584]

5. Schwarz K, Dobiasch S, Nguyen L, et al. (2020) Modification of radiosensitivity by curcumin in human pancreatic cancer cell lines. Sci Rep, 10(1): 3815. [DOI:10.1038/s41598-020-60765-1]

6. Huang BR, Tsai CH, Chen CC, et al. (2019) Curcumin promotes connexin 43 degradation and temozolomide-induced apoptosis in glioblastoma cells. Am J Chin Med, 47(3): 657-674. [DOI:10.1142/S0192415X19500344]

7. Jäättelä M (2004) Multiple cell death pathways as regulators of tumour initiation and progression. Oncogene, 23(16): 2746-2756. [DOI:10.1038/sj.onc.1207513]

8. Blanquicett C, Gillespie GY, Nabors LB, et al. (2002) Induction of thymidine phosphorylase in both irradiated and shielded, contralateral human U87MG glioma xenografts: implications for a dual modality treatment using capecitabine and irradiation. Mol Cancer Ther, 1(12): 1139-1145.

9. Karunagaran D, Rashmi R, Kumar TR (2005) Induction of apoptosis by curcumin and its implications for cancer therapy. Curr Cancer Drug Targets, 5(2):117-129. [DOI:10.2174/1568009053202081]

10. Koul D, Takada Y, Shen R, et al. (2006) PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells. Biochem Biophys Res Commun, 350(2): 463-471. [DOI:10.1016/j.bbrc.2006.09.077]

11. Nagane M, Levitzki A, Gazit A, et al. (1998) Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases. Proc Natl Acad Sci U S A, 95(10): 5724-5729. [DOI:10.1073/pnas.95.10.5724]

12. Biswas DK, Martin KJ, McAlister C, et al. (2003) Apoptosis caused by chemotherapeutic inhibition of nuclear factor-kappaB activation. Cancer Res, 63(2): 290-295.

13. Dalen H and Neuzil J (2003) α-Tocopheryl succinate sensitises a T lymphoma cell line to TRAIL-induced apoptosis by suppressing NF-κB activation. British Journal of Cancer, 88(1): 153-158. [DOI:10.1038/sj.bjc.6600683]

14. Pennarun G, Granotier C, Gauthier LR, et al. (2005) Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands. Oncogene, 24(18): 2917-28. [DOI:10.1038/sj.onc.1208468]

15. Shervington A, Cruickshanks N, Wright H, et al. (2006) Glioma: what is the role of c-Myc, hsp90 and telomerase? Mol Cell Biochem, 283(1-2): 1-9. [DOI:10.1007/s11010-006-2495-z]

16. Woo JH, Kim YH, Choi YJ, et al. (2003) Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis, 24(7): 1199-1208. [DOI:10.1093/carcin/bgg082]

17. Laha D, Pal K, Chowdhuri AR, et al. (2019) Fabrication of curcumin-loaded folic acid-tagged metal organic framework for triple negative breast cancer therapy in in vitro and in vivo systems. New Journal of Chemistry, 43(1): 217-229. [DOI:10.1039/C8NJ03350A]

18. Karmakar S, Banik NL, Patel SJ, et al. (2006) Curcumin activated both receptor-mediated and mitochondria-mediated proteolytic pathways for apoptosis in human glioblastoma T98G cells. Neurosci Lett, 407(1): 53-58. [DOI:10.1016/j.neulet.2006.08.013]

19. Anto RJ, Mukhopadhyay A, Denning K, et al. (2002) Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl. Carcinogenesis, 23(1): 143-150. [DOI:10.1093/carcin/23.1.143]

20. Duvoix A, Blasius R, Delhalle S, et al. (2005) Chemopreventive and therapeutic effects of curcumin. Cancer Lett, 223(2): 181-190. [DOI:10.1016/j.canlet.2004.09.041]

21. Moloudi K, Neshasteriz A, Hosseini A, et al. (2017) Synergistic Effects of Arsenic Trioxide and Radiation: Triggering the Intrinsic Pathway of Apoptosis. Iran Biomed J, 21(5): 330-337. [DOI:10.18869/acadpub.ibj.21.5.330]

22. Su X, Chen S, Lu H, et al. (2021) Study on the inhibitory effect of curcumin on GBM and its potential mechanism. Drug Des Devel Ther, 15: 2769-2781. [DOI:10.2147/DDDT.S306602]

23. Lee Y-J, Park K-S, Lee S-H (2021) Curcumin targets both apoptosis and necroptosis in acidity-tolerant prostate carcinoma cells. BioMed Research International, 2021: 8859181. [DOI:10.1155/2021/8859181]

24. Kim JY, Jung CW, Lee WS, et al. (2022) Interaction of curcumin with glioblastoma cells via high and low linear energy transfer radiation therapy inducing radiosensitization effects. J Radiat Res, 63(3): 342-353. [DOI:10.1093/jrr/rrac016]

25. Hildebrandt B, Wust P, Ahlers O, et al. (2002) The cellular and molecular basis of hyperthermia. Crit Rev Oncol Hematol, 43(1): 33-56. [DOI:10.1016/S1040-8428(01)00179-2]

26. Neshasteh-Riz A, Rahdani R, Mostaar A (2014) Evaluation of The Combined Effects of Hyperthermia, Cobalt-60 Gamma Rays and IUdR on cultured glioblastoma spheroid cells and dosimetry using TLD-100. Cell J, 16(3): 335-342.

27. Rao W, Deng ZS, Liu J (2010) A review of hyperthermia combined with radiotherapy/chemotherapy on malignant tumors. Crit Rev Biomed Eng, 38(1): 101-116. [DOI:10.1615/CritRevBiomedEng.v38.i1.80]

28. Feist M, Huang X, Müller JM, et al. (2014) Can hyperthermic intraperitoneal chemotherapy efficiency be improved by blocking the DNA repair factor COP9 signalosome? Int J Colorectal Dis, 29(6): 673-680. [DOI:10.1007/s00384-014-1861-7]

29. Khaitan D, Chandna S, Arya MB (2006) Establishment and characterization of multicellular spheroids from a human glioma cell line; Implications for tumor therapy. Journal of Translational Medicine, 4(1): 12. [DOI:10.1186/1479-5876-4-12]

30. Carlsson J and Yuhas JM (1984) Liquid-overlay culture of cellular spheroids. Recent Results Cancer Res, 95: 1-23. [DOI:10.1007/978-3-642-82340-4_1]

31. McFadden RM, Larmonier CB, Shehab KW, et al. (2015) The role of curcumin in modulating colonic microbiota during colitis and colon cancer prevention. Inflamm Bowel Dis, 21(11): 2483-2494. [DOI:10.1097/MIB.0000000000000522]

32. Mittal L, Aryal UK, Camarillo IG, et al. (2020) Effective electrochemotherapy with curcumin in MDA-MB-231-human, triple negative breast cancer cells: A global proteomics study. Bioelectrochemistry, 131: 107350. [DOI:10.1016/j.bioelechem.2019.107350]

33. Zhu JY, Yang X, Chen Y, et al. (2017) Curcumin suppresses lung cancer stem cells via inhibiting wnt/β-catenin and sonic hedgehog pathways. Phytother Res, 31(4): 680-688. [DOI:10.1002/ptr.5791]

34. Qian Y, Ma J, Guo X, et al. (2015) Curcumin enhances the radiosensitivity of U87 cells by inducing DUSP-2 up-regulation. Cell Physiol Biochem, 35(4): 1381-1393. [DOI:10.1159/000373959]

35. Dhandapani KM, Mahesh VB, Brann DW (2007) Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factors. J Neurochem, 102(2): 522-538. [DOI:10.1111/j.1471-4159.2007.04633.x]

36. Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol, 35(4): 495-516. [DOI:10.1080/01926230701320337]

37. Zoi V, Galani V, Vartholomatos E, et al. (2021) Curcumin and radiotherapy exert synergistic anti-glioma effect in-vitro. Biomedicines, 9(11). [DOI:10.3390/biomedicines9111562]

38. Aravindan N, Veeraraghavan J, Madhusoodhanan R, et al. (2011) Curcumin regulates low-linear energy transfer γ-radiation-induced NFκB-dependent telomerase activity in human neuroblastoma cells. Int J Radiat Oncol Biol Phys, 79(4): 1206-1215. [DOI:10.1016/j.ijrobp.2010.10.058]

39. Faqihi F, Neshastehriz A, Soleymanifard S, et al. (2015) Radiation-induced bystander effect in non-irradiated glioblastoma spheroid cells. J Radiat Res, 56(5): 777-783. [DOI:10.1093/jrr/rrv039]

40. Hu S, Xu Y, Meng L, et al. (2018) Curcumin inhibits proliferation and promotes apoptosis of breast cancer cells. Exp Ther Med, 16(2): 1266-1272. [DOI:10.3892/etm.2018.6345]

41. Iliakis G, Wu W, Wang M (2008) DNA double strand break repair inhibition as a cause of heat radiosensitization: re-evaluation considering backup pathways of NHEJ. Int J Hyperthermia, 24(1): 17-29. [DOI:10.1080/02656730701784782]

42. Takahashi A, Matsumoto H, Nagayama K, et al. (2004) Evidence for the involvement of double-strand breaks in heat-induced cell killing. Cancer Res, 64(24): 8839-8845. [DOI:10.1158/0008-5472.CAN-04-1876]

43. Chendil D, Ranga RS, Meigooni D, et al. (2004) Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3. Oncogene, 23(8):1599-1607. [DOI:10.1038/sj.onc.1207284]

44. Lohr F, Hu K, Huang Q, et al. (2000) Enhancement of radiotherapy by hyperthermia-regulated gene therapy. Int J Radiat Oncol Biol Phys, 48(5): 1513-1518. [DOI:10.1016/S0360-3016(00)00788-4]

45. Stankiewicz AR, Livingstone AM, Mohseni N, et al. (2009) Regulation of heat-induced apoptosis by Mcl-1 degradation and its inhibition by Hsp70. Cell Death Differ, 16(4): 638-647. [DOI:10.1038/cdd.2008.189]

46. Tang JC, Shi HS, Wan LQ, et al. (2013) Enhanced antitumor effect of curcumin liposomes with local hyperthermia in the LL/2 model. Asian Pac J Cancer Prev, 14(4): 2307-2310. [DOI:10.7314/APJCP.2013.14.4.2307]

47. Helleday T, Petermann E, Lundin C, et al. (2008) DNA repair pathways as targets for cancer therapy. Nat Rev Cancer, 8(3): 193-204. [DOI:10.1038/nrc2342]

48. Wust P, Hildebrandt B, Sreenivasa G, et al. (2002) Hyperthermia in combined treatment of cancer. Lancet Oncol, 3(8): 487-497. [DOI:10.1016/S1470-2045(02)00818-5]