Health Radiation Research Department, National Centre for Radiation Research and Technology (NCRRT), P. O. Box 29, Nasr City, Cairo, Egypt. Egyptian Atomic Energy Authority, Nasr City, Cairo, Egypt , elkadyah13@gmail.com
Abstract: (471 Views)
Background:Radiotherapy treats over 70% of thoracic tumours; however, the technique frequently causes radiation-pneumonitis. Luteolin exhibits anti-inflammatory properties and inhibits chemotaxis release. The radio protective effects of luteolin on γ-rays-induced pneumonitis in rats were evaluated. Materials and Methods: Thirty-two rats were distributed into four groups. Rats were exposed to 8.5Gy-γ-rays then, treated with or without luteolin for 20-days. Oxidative-stress, antioxidant, anti-inflammatory markers levels, collagen content, and histopathological structures were evaluated in lung tissue. Results: Increased reactive oxygen species (ROS) production and oxidative stress after irradiation were down-regulated by luteolin treatment, demonstrating luteolin’s antioxidant and anti-inflammatory properties. Luteolin attenuated lung histopathological changes which represented by desquamation of bronchiolar epithelia with pre-bronchiolar leukocytic infiltrations, proliferation of pneumocytes type ІІ, emphysema and collapse induced by γ-rays. Conclusion: The current study found, for the first time, that luteolin has a protective effect on whole body γ-rays-induced early lung injury in rat model.
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Tawfik S, El Kady A, Ebrahim R, El khouly W. Protective efficacy of luteolin against γ-rays induced early pneumonitis in rats. Int J Radiat Res 2024; 22 (1) :193-198 URL: http://ijrr.com/article-1-5256-en.html