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Micro-pixe analysis in invasive ductal carcinoma tissues after treatment of astaxanthin
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S. Safaverdi   , F. Roshani , M. Lamehi Rashti , Sh. Golkhoo , Z.M. Hassan , L. Langroudi |
| , hassan_zm@modares.ac.ir |
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Abstract: (17229 Views) |
| Background: Trace elements play an important
role in a number of biological processes. Astaxanthin
(ASX), a carotoid pigment found in certain marine
plant and animals, has shown anti cancer and anti
free radical properties. This work intended to
understand the effect of Astaxanthin in breast cancer
(invasive ductal carcinoma, IDC) by using micro-pixe
method. For this aim the concentration of trace
elements were compared in healthy, cancerous and
cancer treated with astaxanthin in the breast and
liver tissues of breast cancer bearing mice, using
proton induced X-ray emission (PIXE). Materials and
Methods: Proton induced X-ray emission (PIXE) was
used in a study intending to compare the
concentration of trace elements in breast and liver
tissues of mice bearing tumor, three groups of mice:
healthy, cancerous, and cancerous treated by
astaxanthin, were considered. Astaxanthin was
supplied from Research Institute of women, Alzahra
University. Results: Comparing the untreated tumor
tissue, treatment with Astaxanthin significantly
decreased the amount Fe, P, S, and Ca elements
level in tumor tissue of the breast cancer. It is also
found that the concentrations of those elements in
liver of the untreated mice and the liver of treated
mice with astaxanthin were fairly equal. Astaxanthin
significantly decrease the accumulation of elements
in the site of tumor, and caused the breast cancer
cell membrane to lose their desire to collect the
elements from healthy tissues. Conclusion: The micro
-pixe technique could calculate elemental
concentrations in tissues. Changes in metallic
elements may affect microenvironment and cell
functions, which might led lead to cell degeneration
or death, the results shows that astaxanthin reduces
vital element concentration in tumor site, thus it
could be used as an anti tumor agent. Iran. J. Radiat.
Res., 2009 7 (1): 33-39 |
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| Keywords: Breast cancerous tissues, proton-induced X-ray emission, astaxanthin, trace elements. |
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Full-Text [PDF 413 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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