[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
IJRR Information::
About the Journal
Editorial Board
Keywords
For Authors::
Aims and Scope
Call for Papers
Submission Instructions
For Reviewers::
Referee page
Subscription::
Subscription Form
News & Events::
Journal News
Web Mail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
ISSN
Hard Copy 2322-3243
Online 2345-4229
..
Online Submission
Now you can send your articles to IJRR office using the article submission system.
..

AWT IMAGE

AWT IMAGE
Volume 22, Issue 2 (4-2024)                   Int J Radiat Res 2024, 22(2): 387-393 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Tian X, Shen Z, Wang S, Liu X, Luo H, Jin F. Dosimetric comparison of different radial and longitudinal margins for tomotherapy in esophageal cancer. Int J Radiat Res 2024; 22 (2) :387-393
URL: http://ijrr.com/article-1-5444-en.html
Dosimetric comparison of different radial and longitudinal margins for tomotherapy in esophageal cancer
X. Tian , Z. Shen , S. Wang , X. Liu , H. Luo , F. Jin
Department Radiation Oncology, Chongqing University Cancer Hospital, Chongqing, China , jfazj@126.com
Abstract:   (1067 Views)
Background: This paper aimed to investigate the radiation dosimetry and dose deposition to the surrounded organs at risk (OARs) with different radial and longitudinal margins based on the normal tissue complication probability (NTCP) and dose-volume histogram (DVH) methods. Materials and Methods: Fifteen patients with histologically diagnosed esophageal cancer were retrospectively selected. From the clinical target volume (CTV), eight planning target volumes (PTV) were expanded for each patient, with one group of four radial margins (3mm, 5mm, 7mm, 10mm) and the other group of four longitudinal margins (3mm, 5mm, 7mm, 10mm). Then, eight plans with the prescription dose of 50.4Gy were designed in the tomotherapy system. Within each group, doses for the OARs and NTCP-based risk of pneumonitis and pericardial disease were compared. Results: Almost all the dose parameters in both groups, except for the Dmax (maximum dose) of the spinal cord in the longitudinal direction, showed significant linearly increasing trends with the expansion of margins. For same dose parameters, the increased slopes in the radial direction were larger than those in the longitudinal. Heart V30Gy (the percent volume of receiving 30Gy) grew fastest compared to other clinical constraint indexes in both groups, and the most significant difference in the risk of pneumonitis was observed in the radial group when the margin was expanded from 3 to 10mm. Conclusions: In order to lower the likelihood of radiation-related toxicity, radial margin expansion should be more strictly controlled in the radiotherapy of esophageal cancer with tomotherapy.
Keywords: Esophageal cancer, tomotherapy, margins, radiation dosimetry.
Full-Text [PDF 788 kb]   (411 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
References
1. 1. Siegel RL, Miller KD, Wagle NS, Jemal A (2023) Cancer statistics, 2023. CA Cancer J Clin, 73(1): 17-48. [DOI:10.3322/caac.21763]
2. Park S, Oh D, Choi YL, et al. (2022) Durvalumab and tremelimumab with definitive chemoradiotherapy for locally advanced esophageal squamous cell carcinoma. Cancer, 128(11):2148-2158. [DOI:10.1002/cncr.34176]
3. Shah MA, Bennouna J, Doi T, Shen L, et al. (2021) KEYNOTE-975 study design: a phase III study of definitive chemoradiotherapy plus pembrolizumab in patients with esophageal carcinoma. Future Oncol, 17(10): 1143-1153. [DOI:10.2217/fon-2020-0969]
4. Cinicola J, Mamidanna S, Yegya-Raman N, et al. (2023) A review of advances in radiotherapy in the setting of esophageal cancers. Surg Oncol Clin N Am, 32(3): 433-459. [DOI:10.1016/j.soc.2023.03.004]
5. Hridya VT, Khanna D, Aswathi R, et al. (2023) A study to evaluate optimal plan through different photon. Int J Radiat Res, 21(2): 337-342.
6. Lee SL, Mahler P, Olson S, et al. (2021) Reduction of cardiac dose using respiratory-gated MR-linac plans for gastro-esophageal junction cancer. Med Dosim, 46(2): 152-156. [DOI:10.1016/j.meddos.2020.10.002]
7. Vošmik M, Hodek M, Buka D, et al. (2020) Cardiotoxicity of radiation therapy in esophageal cancer. Reports of Practical Oncology & Radiotherapy, 25(3): 318-22. [DOI:10.1016/j.rpor.2020.02.005]
8. Boekhoff MR, Defize IL, Borggreve AS, et al. (2021) CTV-to-PTV margin assessment for esophageal cancer radiotherapy based on an accumulated dose analysis. Radiother Oncol, 161:16-22. [DOI:10.1016/j.radonc.2021.05.005]
9. Voncken FEM, Nakhaee S, Stam B, et al. (2020) Quantification of esophageal tumor motion and investigation of different image-guided correction strategies. Pract Radiat Oncol, 10(2): 84-92. [DOI:10.1016/j.prro.2019.11.012]
10. Hoffmann L, Poulsen PR, Ravkilde T, et al. (2019) Setup strategies and uncertainties in esophageal radiotherapy based on detailed intra-and interfractional tumor motion mapping. Radiother Oncol, 136:161-168. [DOI:10.1016/j.radonc.2019.04.014]
11. Monadi N, Shahbazi-Gahrouei D, et al. (2023) Dosimetric characteristics of tomotherapy and three dimensional conformal radiotherapy for head and neck. Int J Radiat Res, 21(3):427-434. [DOI:10.61186/ijrr.21.3.427]
12. Watcharawipha A, Chitapanarux I, Jia-Mahasap B (2022) Dosimetric comparison of large field widths in helical tomotherapy for intracranial stereotactic radiosurgery. Int J Radiat Res, 20(3):701-707.
13. Kirli-Bolukbas M and Karaca S (2020) Effect of lung volume on helical radiotherapy in esophageal cancer: are there predictive factors to achieve acceptable lung doses? Strahlenther Onkol, 196(9): 805-812. [DOI:10.1007/s00066-020-01581-4]
14. Guo MF, Zhao XJ, Huang Y, et al. (2022) The dosimetric and clinical comparison between helical tomotherapy and fixed-field intensity-modulated radiotherapy in radical irradiation for cervical cancer. Int J Radiat Res, 20(2):377-382. [DOI:10.52547/ijrr.20.2.18]
15. Wang Y, Xiao Q, Zeng B, et al. (2020) Tomotherapy as a neoadjuvant treatment for locally advanced esophageal cancer might increase bone marrow toxicity in comparison with intensity-modulated radiotherapy and volumetric-modulated arc therapy. Med Dosim, 45(1): e6-e12. [DOI:10.1016/j.meddos.2019.05.001]
16. Gu Q, Lai XJ, Yang SY, et al. (2017) Dosimetric comparison between helical tomotherapy and intensity-modulated radiotherapy for esophageal carcinoma. Precision Radiation Oncology, 1(3):88-93. [DOI:10.1002/pro6.21]
17. Gay HA and Niemierko A (2007) A free program for calculating EUD-based NTCP and TCP in external beam radiotherapy. Phys Med, 23(3-4): 115-125. [DOI:10.1016/j.ejmp.2007.07.001]
18. Kastelowitz N, Marsh MD, McCarter M, et al. (2021) Impact of radiation dose on postoperative complications in esophageal and gastroesophageal junction cancers. Front Oncol, 11. [DOI:10.3389/fonc.2021.614640]
19. Takeuchi Y, Murakami Y, Kameoka T, et al. (2020) Analysis of cardiac toxicity after definitive chemoradiotherapy for esophageal cancer using a biological dose-volume histogram. J Radiat Res, 61(2):298-306. [DOI:10.1093/jrr/rraa001]
20. Yakar M, Etiz D, Metintas M, et al. (2021) Prediction of radiation pneumonitis with machine learning in stage III lung cancer: A pilot study. Technol. Cancer Res Treat, 20:1-10. [DOI:10.1177/15330338211016373]
21. Mijiti M, Li D, Yan R, et al. (2023) Development of nomogram for predicting major complications in patients with esophageal cancer in the early postoperative period. BMC Surg, 23(1):186. [DOI:10.1186/s12893-023-02090-8]
22. Katsuta T, Murakami Y, Kawahara D, et al. (2023) Novel simulation for dosimetry impact of diaphragm respiratory motion in four-dimensional volumetric modulated arc therapy for esophageal cancer. Radiother Oncol, 187. [DOI:10.1016/j.radonc.2023.109849]
23. Münch S, Oechsner M, Combs SE, Habermehl D (2017) DVH- and NTCP-based dosimetric comparison of different longitudinal margins for VMAT-IMRT of esophageal cancer. Radiat Oncol, 12:128. [DOI:10.1186/s13014-017-0871-3]
24. Tang W, Li X, Yu H, et al. (2021) A novel nomogram containing acute radiation esophagitis predicting radiation pneumonitis in thoracic cancer receiving radiotherapy. BMC Cancer, 21(1):585. [DOI:10.1186/s12885-021-08264-y]
25. Inoo H, Sakanaka K, Fujii K, et al. (2022) Association of volumetric-modulated arc therapy with radiation pneumonitis in thoracic esophageal cancer. Int J Radiat Res, 63(4):646-656. [DOI:10.1093/jrr/rrac021]
26. Tonison JJ, Fischer SG, Viehrig M, et al. (2019) Radiation pneumonitis after intensity-modulated radiotherapy for esophageal cancer: Institutional data and a systematic review. Sci Rep, 9(1): 2255. [DOI:10.1038/s41598-018-38414-5]
27. Luna JM, Chao H-H, Diffenderfer ES, et al. (2019) Predicting radiation pneumonitis in locally advanced stage II-III non-small cell lung cancer using machine learning. Radiother Oncol, 133:106-112. [DOI:10.1016/j.radonc.2019.01.003]
28. Boekhoff MR, Lagendijk JJW, van Lier ALHMW, et al. (2023) Intrafraction motion analysis in online adaptive radiotherapy for esophageal cancer. Phys Imag Radiat Onc, 26. [DOI:10.1016/j.phro.2023.100432]
29. Frandsen J, Boothe D, Gaffney DK, et al. (2015) Increased risk of death due to heart disease after radiotherapy for esophageal cancer. J Gastrointest Oncol, 6(5):516-523.
30. Tao Y, Lu J, Deng W, et al. (2023) Correlation of mean heart dose and cardiac biomarkers with electrocardiographic changes in patients receiving thoracic radiation therapy. Radiat Res, 199(4): 336-345. [DOI:10.1667/RADE-22-00135.1]
31. Goldoost B, Goldoost N, Esnaashari O, Mostafanezhad K (2019) Evaluating the effects of esophageal and breast cancer. Int J Radiat Res, 17(2):237-244.
32. Wang X, Palaskas NL, Yusuf SW, et al. (2020) Incidence and onset of severe cardiac events after radiotherapy for esophageal cancer. J Thorac Oncol, 15(10):1682-1690. [DOI:10.1016/j.jtho.2020.06.014]
Add your comments about this article : Your username or Email:
CAPTCHA
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
International Journal of Radiation Research
Persian site map - English site map - Created in 0.05 seconds with 50 queries by YEKTAWEB 4718