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:: Volume 22, Issue 2 (4-2024) ::
Int J Radiat Res 2024, 22(2): 505-508 Back to browse issues page
Atorvastatin calcium tablets effectively alleviated the morphine tolerance in the management of cancer pain
LF. Quan , J. Fan
Department of Oncology, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China , fanjuan_edu@hotmail.com
Abstract:   (752 Views)
Background: The aim of this study was to elucidate the efficacy of atorvastatin calcium tablets to relieve morphine tolerance in cancer pain patients. Materials and Methods: Cancer patients were randomized into the control and observational groups. The morphine dose increment time (T2), the onset time of morphine (T1), the titration dose and pain management rate in the two groups were evaluated and compared. Adverse events such as nausea, vomiting, constipation and respiratory depression were recorded. The impact of different treatments on the life quality of patients was assessed with Karnofsky performance status (KPS) score. Liver function and hematologic toxicities of different treatment was evaluated and examined. Results: The duration of T2 was significantly prolonged in the observational group (P=0.04), while the time of T1 as well as the titration dose showed no significant difference between the two groups (P>0.05). The adverse effects were slighter in the observational group (P>0.05). There was no respiratory depression case in either group. The life quality in two groups of patients showed no difference (P>0.05). Liver function and hematologic toxicitie results indicated that the combined treatment showed no extra damage to liver function and had no severe haematologic toxicity compared with the control. Conclusion: The combined treatment of atorvastatin calcium tablets and morphine effectively prolonged the time between morphine dose increments, alleviating the morphine tolerance with high safety in cancer pain patients, which may provide clues for morphine tolerance treatment in cancer pain management.
Keywords: Morphine, Drug tolerance, atorvastatin calcium, cancer pain.
Full-Text [PDF 499 kb]   (216 Downloads)    
Type of Study: Short Report | Subject: Radiation Biology
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Quan L, Fan J. Atorvastatin calcium tablets effectively alleviated the morphine tolerance in the management of cancer pain. Int J Radiat Res 2024; 22 (2) :505-508
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Volume 22, Issue 2 (4-2024) Back to browse issues page
International Journal of Radiation Research
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