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Volume 22, Issue 2 (4-2024)                   Int J Radiat Res 2024, 22(2): 515-519 | Back to browse issues page

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Neshastehriz A, Hormozi-Moghaddam Z, Amini S, Taheri S, Abedi Kichi Z. Combined sonodynamic therapy and X-ray radiation with methylene blue and gold nanoparticles coated with apigenin: Impact on MCF7 cell viability. Int J Radiat Res 2024; 22 (2) :515-519
URL: http://ijrr.com/article-1-5488-en.html
Combined sonodynamic therapy and X-ray radiation with methylene blue and gold nanoparticles coated with apigenin: Impact on MCF7 cell viability
A. Neshastehriz , Z. Hormozi-Moghaddam , S.M. Amini , S.M. Taheri , Z. Abedi Kichi
Department of Radiation Sciences, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran , Hormozimoghadam.z@iums.ac.ir
Abstract:   (1446 Views)
Background: This study investigates the efficacy of sonodynamic and low-dose radiation with methylene blue and gold nanoparticles coated with apigenin sonosensitizer on breast cancer cells. Method and Materials: HR-TEM, UV-visible, zeta-potential, FTIR, and DLS were used to confirm the synthesized gold nanoparticles coated with apigenin. The concentration of gold nanoparticles coated with apigenin and methylene blue was calculated, and then ultrasound and 2 Gy x-rays were used to irradiate them. Results: The results showed that sonodynamic therapy in combination with radiation at a concentration of 8 µg/ml nanoparticles and 0.4 µmol methylene blue had a significant effect on cell death (0.26± 0.02). Conclusion: This study highlights the potential of sonodynamic therapy as a non-ionizing and non-invasive treatment, as well as the possibility of eliminating the side effects of cancer treatment by using green nanoparticles rather than chemical sensitizers.
Keywords: Sonodynamic therapy, radiation, gold nanoparticles, Apigenin, methylene blue.
Full-Text [PDF 681 kb]   (391 Downloads)    
Type of Study: Short Report | Subject: Radiation Biology
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