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Clinical efficacy and safety of laparoscopic radical surgery and radiotherapy for the treatment of early-stage gallbladder cancer
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A.S. GuiFen Wei   , H. Ao , H. Yan , J. Huang |
| Department of Hepatobiliary and Pancreatic Surgery, The Second People's Hospital of Tongxiang, Zhejiang, 314511, China , Dr.med.he1234@gmail.com |
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Abstract: (640 Views) |
Background: Gallbladder cancer (GBC) is a challenging malignancy with poor prognosis. Although radical cholecystectomy is the accepted surgical approach, the safety and effectiveness of laparoscopic radical surgery and radiotherapy are remained under-studied. Materials and Methods: A single-center, prospective study was conducted from May 2020 to May 2023. One hundred patients diagnosed with early-stage GBC were categorized into two groups: an Intervention Group (n=50) that underwent laparoscopic radical surgery and radiotherapy, and a Control Group (n=50) that received conventional open surgery. Key indicators such as surgical conditions, postoperative rehabilitation, and survival rates were evaluated in both groups. Results: The Intervention Group demonstrated superior surgical outcomes, including a significantly reduced surgical bleeding volume (198.5±23.1 vs. 286.3±18.7 ml, P-value <0.001), shorter operative duration (168.6±64.8 vs. 261.1±55.3 min, P-value <0.001), and smaller incision length (1.1±0.3 vs. 8.2±1.2 cm, P-value <0.001). Postoperatively, the Intervention Group also showed marked improvements in hospital stay duration (7.5±1.4 vs. 9.3±2.9 days, P-value <0.001), time to first ambulation (2.1±0.8 vs. 6.9±1.1 days, P-value <0.001), and gastric function recovery (2.2±0.6 vs. 3.5±1.3 days, P-value <0.001). Complication rates were lower, with abdominal infections observed in 0 cases in the Intervention Group compared to 4 cases (8%) in the Control Group (P-value:0.041). Long-term follow-up indicated a trend toward better 3-year survival rates in the Intervention Group (84% vs 68%, P-value: 0.061). Conclusion: Our findings suggest that laparoscopic radical cholecystectomy is a viable and safe option for treating early-stage GBC, aligning with existing literature that advocates for minimally invasive surgical approaches. |
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| Keywords: Early-stage gallbladder cancer, Laparoscopic radical cholecystectomy, postoperative outcomes, prospective cohort study, surgical Efficacy. |
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Full-Text [PDF 466 kb]
(184 Downloads)
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Type of Study: Short Report |
Subject:
Radiation Biology
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| References |
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GuiFen Wei A, Ao H, Yan H, Huang J. Clinical efficacy and safety of laparoscopic radical surgery and radiotherapy for the treatment of early-stage gallbladder cancer. Int J Radiat Res 2024; 22 (3) :767-770 URL: http://ijrr.com/article-1-5664-en.html
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