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The effect of simultaneous low-dose splenic irradiation on immune function during esophageal cancer radiotherapy
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X. Shi   , X. Nan , J. Ren , X. Zhang , X. Li , Y. Gao |
| Department of Radiotherapy, Beijing Luhe Hospital, affiliated to Capital Medical University, Beijing, 100110, China , gyy2023@sina.com |
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Abstract: (384 Views) |
Background: The objective of this study was to examine the impact of synchronous low-dose splenic irradiation (LDSR) on immune function in patients with esophageal cancer undergoing radiotherapy. Materials and Methods: Twenty-one patients who were diagnosed with esophageal cancer were randomly allocated to either the control or experimental groups. The control group received routine radiotherapy alone, whereas the experimental group underwent simultaneous LDSR during radiotherapy. Low dosage radiation refers to a beam with a low linear energy transfer (LET) that delivers a dose of 0.2 Gy or less, or a high LET beam that delivers a dose of 0.05 Gy or less, while maintaining an exposure dose rate of 0.005 cGy/min. The lymphocyte subsets in the two groups were analyzed using flow cytometry at various time points during and after treatment. Additionally, complications and their occurrence times were recorded simultaneously. Results: Gradual decreases were observed in CD16+CD56+, CD3+CD4+, and CD4+/CD8+ ratios following radiotherapy in the control group (p < 0.05). However, no considerable differences were observed between the experimental groups in these ratios (p > 0.05). LDSR was found to induce immunological enhancement and counteract immune suppression caused by radiotherapy. Furthermore, the experimental group experienced larger cumulative dosages that led to problems compared to the control group, with a delayed onset. Despite receiving a higher cumulative dose, the experimental group exhibited lower levels of myelosuppression and radiation esophagitis than the control group (p < 0.05). Overall, the results suggest that synchronous LDSR can enhance immune function during radiotherapy in patients with esophageal cancer and reduce the adverse effects associated with routine radiotherapy. Conclusion: Synchronous LDSR may induce immunological enhancement during radiotherapy in patients with esophageal cancer, reduce adverse reactions to routine radiotherapy, and enhance tolerance. |
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| Keywords: Esophageal cancer, Immunity, Radiotherapy, Spleen, Lymphocytes. |
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Full-Text [PDF 863 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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1. 1. Lindell B and Sowby D (2008) The 1958 UNSCEAR report. Journal of Radiological Protection, 28(3): 277. [ DOI:10.1088/0952-4746/28/3/R01] [ PMID] 2. Herrera FG, Ronet C, Ochoa de Olza M, Barras D, Crespo I, Andreatta M, et al. (2022) Low-dose radiotherapy reverses tumor immune desertification and resistance to immunotherapy. Cancer Discovery, 12(1): 108-133. [ DOI:10.1158/2159-8290.CD-21-0003] [ PMID] [ ] 3. Zhang Z, Liu X, Chen D, Yu J (2022) Radiotherapy combined with immunotherapy: the dawn of cancer treatment. Signal Transduction and Targeted Therapy, 7(1): 258. [ DOI:10.1038/s41392-022-01102-y] [ PMID] [ ] 4. Liu X, Liu Z, Wang D, Han Y, Hu S, Xie Y, et al. (2020) Effects of low dose radiation on immune cells subsets and cytokines in mice. Toxicology research, 9(3): 249-262. [ DOI:10.1093/toxres/tfaa017] [ PMID] [ ] 5. Yang ZW, Li JA, Yang MH, Feng YS, Tang Z, Dai XS, et al. (2005) Comparison of blood counts in splenic, renal and mesenteric arterial and venous blood in post-pubertal rabbits. Research in veterinary science, 79(2): 149-154. [ DOI:10.1016/j.rvsc.2004.11.008] [ PMID] 6. Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, et al. (2016) Cancer statistics in China, 2015. CA: a cancer journal for clinicians, 66(2): 115-132. [ DOI:10.3322/caac.21338] [ PMID] 7. Zhu M, Yang M, Zhang J, Yin Y, Fan X, Zhang Y, et al. (2021) Immunogenic cell death induction by ionizing radiation. Frontiers in immunology, 12: 705361. [ DOI:10.3389/fimmu.2021.705361] [ PMID] [ ] 8. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians, 71(3): 209-249. [ DOI:10.3322/caac.21660] [ PMID] 9. Johnson RE, Foley HT, Swain RW, O'Conor GT (1967) Treatment of lymphosarcoma with fractionated total body irradiation. Cancer, 20(4): 482-485.
https://doi.org/10.1002/1097-0142(1967)20:4<482::AID-CNCR2820200404>3.0.CO;2-3 [ DOI:10.1002/1097-0142(1967)20:43.0.CO;2-3] 10. Chen S, Cai L, Meng Q, Xu S, Wan H, Liu S (2000) Low-dose whole-body irradiation (LD-WBI) changes protein expression of mouse thymocytes: effect of a LD-WBI-enhanced protein RIP10 on cell proliferation and spontaneous or radiation-induced thymocyte apoptosis. Toxicological Sciences, 55(1): 97-106. [ DOI:10.1093/toxsci/55.1.97] [ PMID] 11. Liu J, Zhou J, Wu M, Hu C, Yang J, Li D, et al. (2019) Low-dose total body irradiation can enhance systemic immune related response induced by hypo-fractionated radiation. Frontiers in immunology, 10: 317. [ DOI:10.3389/fimmu.2019.00317] [ PMID] [ ] 12. Savage T, Pandey S, Guha C (2020) Postablation modulation after single high-dose radiation therapy improves tumor control via enhanced immunomodulation. Clinical Cancer Research, 26(4): 910-921. [ DOI:10.1158/1078-0432.CCR-18-3518] [ PMID] 13. Yamashita M, Suda T (2020) Low-dose X-rays leave scars on human hematopoietic stem and progenitor cells: the role of reactive oxygen species. haematologica, 105(8): 1986. [ DOI:10.3324/haematol.2020.254292] [ PMID] [ ] 14. Wang P, Li Y-W, Lu X, Liu Y, Tian X-L, Gao L, et al. (2023) Low-dose ionizing radiation: Effects on the proliferation and migration of lens epithelial cells via activation of the Wnt/β-catenin pathway. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 888: 503637. [ DOI:10.1016/j.mrgentox.2023.503637] [ PMID] 15. Lumniczky K, Impens N, Armengol G, Candéias S, Georgakilas AG, Hornhardt S, et al. (2021) Low dose ionizing radiation effects on the immune system. Environment international, 149: 106212. [ DOI:10.1016/j.envint.2020.106212] [ PMID] [ ] 16. Tang FR, Loganovsky K (2018) Low dose or low dose rate ionizing radiation-induced health effect in the human. Journal of environmental radioactivity, 192: 32-47. [ DOI:10.1016/j.jenvrad.2018.05.018] [ PMID] 17. Yin L, Xue J, Li R, Zhou L, Deng L, Chen L, et al. (2020) Effect of low-dose radiation therapy on abscopal responses to hypofractionated radiation therapy and anti-PD1 in mice and patients with non-small cell lung cancer. International Journal of Radiation Oncology* Biology* Physics, 108(1): 212-224. [ DOI:10.1016/j.ijrobp.2020.05.002] [ PMID] 18. Cho SJ, Kang H, Hong EH, Kim JY, Nam SY (2018) Transcriptome analysis of low-dose ionizing radiation-impacted genes in CD4+ T-cells undergoing activation and regulation of their expression of select cytokines. Journal of Immunotoxicology, 15(1): 137-146. [ DOI:10.1080/1547691X.2018.1521484] [ PMID] 19. Hussien SM (2023) Radio-adaptive Response Induced by Low-dose Ionizing Radiation in Innate Immunity for Radiotherapy. Health Physics, 124(3): 166-174. [ DOI:10.1097/HP.0000000000001649] [ PMID] 20. Wang B, Li B, Dai Z, Ren S, Bai M, Wang Z, et al. (2014) Low-dose splenic radiation inhibits liver tumor development of rats through functional changes in CD4+ CD25+ Treg cells. The international journal of biochemistry & cell biology, 55: 98-108. [ DOI:10.1016/j.biocel.2014.08.014] [ PMID] 21. Passelli K, Repáraz D, Herrera FG (2023) Opportunities and challenges of low-dose radiation to enable immunotherapy efficacy. International Review of Cell and Molecular Biology, 378: 137-156. [ DOI:10.1016/bs.ircmb.2023.03.010] [ PMID] |
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Shi X, Nan X, Ren J, Zhang X, Li X, Gao Y. The effect of simultaneous low-dose splenic irradiation on immune function during esophageal cancer radiotherapy. Int J Radiat Res 2024; 22 (4) :903-908 URL: http://ijrr.com/article-1-5747-en.html
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