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:: Volume 22, Issue 4 (10-2024) ::
Int J Radiat Res 2024, 22(4): 1027-1035 Back to browse issues page
Protective effect of Zingiber officinale extract and vitamin C in modulating radiation-induced brain damage in male albino rats
D.S. Mansour , R.M. Morsi , A.M. Mousa
Biological Applications Department, Nuclear Research Center, Atomic Energy Authority, Egypt , amr_halim72@yahoo.com
Abstract:   (325 Views)
Background: Radiation therapy is associated with a risk of long-term adverse effects. Ginger extract has several components that have many biological activities and vitamin c has also been recognized for protection against radiation-induced cell damage. The present study is designed to investigate the possible ameliorating effect of ginger extract and vitamin C on radiation-induced oxidative body damage.  Ginger extract and vitamin C were daily given to rats during 14 days before starting irradiation. Materials and Method: Rats were exposed to gamma radiation (6 Gray). Results: the result revealed that the levels of lipid peroxidation measured in brain tissues such as malondialdehyde (MDA), acetylcholinesterase (AChE) were significantly increased, while reduced the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) content, dopamine (DA) and serotonin (ST) levels were significantly decreased in the brain homogenate of irradiated rats. Gamma-irradiation (6 Gy) resulted in a significant elevation in inflammatory markers of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-12 (IL-12) and C-reactive protein (CRP) compared to the control group. The rats that were administrated combined treatment with ginger extract and vitamin C showed significantly less severe damage and remarkable improvement in all of the last mentioned parameters when compared to irradiated rats. Conclusions: According to the results obtained it could be concluded that a combined treatment with ginger extract by its antioxidant constituents, and vitamin C might be a useful candidate against radiation-induced oxidative stress, enzyme activities in the brain and metabolic disorders without any toxicity.
Keywords: Gamma radiation, brain, Ginger extract, vitamin C, oxidative stress, antioxidants.
Full-Text [PDF 673 kb]   (105 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
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Mansour D, Morsi R, Mousa A. Protective effect of Zingiber officinale extract and vitamin C in modulating radiation-induced brain damage in male albino rats. Int J Radiat Res 2024; 22 (4) :1027-1035
URL: http://ijrr.com/article-1-5801-en.html


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Volume 22, Issue 4 (10-2024) Back to browse issues page
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