[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
IJRR Information::
For Authors::
For Reviewers::
Subscription::
News & Events::
Web Mail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
ISSN
Hard Copy 2322-3243
Online 2345-4229
..
Online Submission
Now you can send your articles to IJRR office using the article submission system.
..

AWT IMAGE

AWT IMAGE

:: Volume 23, Issue 1 (1-2025) ::
Int J Radiat Res 2025, 23(1): 163-168 Back to browse issues page
Efficacy and safety of hypofractionated radiotherapy and conventional fractionated radiotherapy in the treatment of early breast cancer patients after breast-conserving surgery
J. Tang , X. Xu , M. Chen , L. Liu , Z. Zhan
Department of Oncology, Pingxiang People’s Hospital, Pingxiang, Jiangxi 337055, China , jiangxtjl350@163.com
Abstract:   (325 Views)
Background: To compare the efficacy as well as safety of hypofractionated radiotherapy (HFRT) with conventional fractionated radiotherapy (CFRT) for the treatment of early breast cancer (EBC) patients after breast-conserving surgery (BCS). Materials and Methods: Clinical data of 126 early breast cancer patients diagnosed and treated in our hospital from March 2021 to June 2023 were retrospectively analyzed. Patients were divided into HFRT group and CFRT group. The CFRT group accepted conventional segment radiotherapy. The HFRT group accepted hypofractionated radiotherapy. The clinical effect, breast beauty effect, incidence of adverse reactions, duration of hospital stay, local recurrence as well as distant metastasis in two groups were compared. Results: The HFRT and CFRT group showed no statistical difference in total response rate, breast beauty effect, length of hospital stay, local recurrence and distant metastasis rate (P>0.05). The incidence of bone marrow suppression, acute skin adverse reactions and radiation pneumonia in the HFRT group was lower than that in the CFRT group (P<0.05). The advanced skin adverse reactions were not statistically different between groups (P>0.05). Conclusion: Conventional radiotherapy and hypofractionated radiotherapy have similar clinical efficacy and safety for early breast cancer patients after BCS, while hypofractionated radiotherapy with the advantages of less radiotherapy times, short course of treatment and higher safety is valuable for clinical treatment.
Keywords: Breast cancer, breast conserving surgery, hypofractionated radiotherapy.
Full-Text [PDF 588 kb]   (33 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
References
1. 1. Lei S, Zheng R, Zhang S, et al. (2021) Breast cancer incidence and mortality in women in China: temporal trends and projections to 2030. Cancer Biol Med, 18(3): 900-9. [DOI:10.20892/j.issn.2095-3941.2020.0523]
2. Woolston C (2015) Breast cancer. Nature, 527(7578): S101. [DOI:10.1038/527S101a]
3. Bhushan A, Gonsalves A, Menon JU (2021) Current state of breast cancer diagnosis, treatment, and theranostics. Pharmaceutics, 13(5): 723. [DOI:10.3390/pharmaceutics13050723]
4. Kunkler IH, Williams LJ, Jack WJL, et al. (2023) Breast-conserving surgery with or without irradiation in early breast cancer. N Engl J Med, 388(7): 585-594. [DOI:10.1056/NEJMoa2207586]
5. Zehra S, Doyle F, Barry M, et al. (2020) Health-related quality of life following breast reconstruction compared to total mastectomy and breast-conserving surgery among breast cancer survivors: a systematic review and meta-analysis. Breast Cancer, 27(4): 534-566. [DOI:10.1007/s12282-020-01076-1]
6. Burstein HJ, Curigliano G, Thürlimann B, et al. (2021) Customizing local and systemic therapies for women with early breast cancer: the St. Gallen International Consensus Guidelines for treatment of early breast cancer 2021. Ann Oncol, 32(10): 1216-1235.
7. Hennequin C, Belkacémi Y, Bourgier C, et al. (2022) Radiotherapy of breast cancer. Cancer Radiother, 26(1-2): 221-230. [DOI:10.1016/j.canrad.2021.11.013]
8. Yarnold J (2019) Changes in radiotherapy fractionation-breast cancer. Br J Radiol, 92(1093): 20170849. [DOI:10.1259/bjr.20170849]
9. Meattini I, Becherini C, Boersma L, et al. (2022) European Society for Radiotherapy and Oncology Advisory Committee in Radiation Oncology Practice consensus recommendations on patient selection and dose and fractionation for external beam radiotherapy in early breast cancer. Lancet Oncol, 23(1): e21-e31. [DOI:10.1016/S1470-2045(21)00539-8]
10. Castaneda SA and Strasser J (2017) Updates in the treatment of breast cancer with radiotherapy. Surg Oncol Clin N Am, 26(3): 371-382. [DOI:10.1016/j.soc.2017.01.013]
11. Offersen BV, Alsner J, Nielsen HM, et al. (2020) Hypofractionated versus standard fractionated radiotherapy in patients with early breast cancer or ductal carcinoma in situ in a randomized phase III trial: The DBCG HYPO Trial. J Clin Oncol, 38(31): 3615-3625. [DOI:10.1200/JCO.20.01363]
12. Whelan TJ, Pignol JP, Levine MN, et al. (2010) Long-term results of hypofractionated radiation therapy for breast cancer. N Engl J Med, 362(6): 513-20. [DOI:10.1056/NEJMoa0906260]
13. De la Cruz Ku G, Karamchandani M, Chambergo-Michilot D, et al. (2022) Does breast-conserving surgery with radiotherapy have a better survival than mastectomy? A meta-analysis of more than 1,500,000 patients. Ann Surg Oncol, 29(10): 6163-6188. [DOI:10.1245/s10434-022-12133-8]
14. Zeng L, Xie XQ, Luo T, et al. (2021) Progress of radiotherapy after breast-conserving surgery combined with silicone prosthesis reconstruction. Eur Rev Med Pharmacol Sci, 25(5): 2193-2198.
15. Esposito E, Anninga B, Harris S, et al. (2015) Intraoperative radiotherapy in early breast cancer. Br J Surg, 102(6): 599-610. [DOI:10.1002/bjs.9781]
16. Jagsi R, Falchook AD, Hendrix LH, et al. (2014) Adoption of hypofractionated radiation therapy for breast cancer after publication of randomized trials. Int J Radiat Oncol Biol Phys, 90(5): 1001-9. [DOI:10.1016/j.ijrobp.2014.09.032]
17. Upadhyay R and Bazan JG (2023) Advances in radiotherapy for breast cancer. Surg Oncol Clin N Am, 32(3): 515-536. [DOI:10.1016/j.soc.2023.03.002]
18. Shah C, Bauer-Nilsen K, McNulty RH, et al. (2020) Novel radiation therapy approaches for breast cancer treatment. Semin Oncol, 47(4): 209-216. [DOI:10.1053/j.seminoncol.2020.05.003]
19. Rivin Del Campo E and Rivera S (2018) Hypofractionated radiotherapy for breast cancer in elderly patients: current evidence and future perspectives. Cancer Radiother, 22(6-7): 635-639. [DOI:10.1016/j.canrad.2018.07.127]
20. Krug D, Baumann R, Combs SE, et al. (2021) Moderate hypofractionation remains the standard of care for whole-breast radiotherapy in breast cancer: Considerations regarding FAST and FAST-Forward. Strahlenther Onkol, 197(4): 269-280. [DOI:10.1007/s00066-020-01744-3]
21. Liu L, Yang Y, Guo Q, et al. (2020) Comparing hypofractionated to conventional fractionated radiotherapy in postmastectomy breast cancer: a meta-analysis and systematic review. Radiat Oncol, 15(1): 17. [DOI:10.1186/s13014-020-1463-1]
22. Schneider U, Sumila M, Robotka J, et al. (2011) Dose-response relationship for breast cancer induction at radiotherapy dose. Radiat Oncol, 6: 67. [DOI:10.1186/1748-717X-6-67]
23. Zwicker F, Hoefel S, Kirchner C, et al. (2021) Hypofractionated radiotherapy with simultaneous-integrated boost after breast-conserving surgery compared to standard boost-applications using helical tomotherapy with TomoEdge. Anticancer Res, 41(4): 1909-1920. [DOI:10.21873/anticanres.14957]
24. Wei NN, Li F, Cai P, et al. (2020) Progress of clinical study on hypofractionated radiotherapy after breast-conserving surgery. Ann Palliat Med, 9(2): 463-471. [DOI:10.21037/apm.2020.02.18]
25. Wang SL, Fang H, Song YW, et al. (2019) Hypofractionated versus conventional fractionated postmastectomy radiotherapy for patients with high-risk breast cancer: a randomised, non-inferiority, open-label, phase 3 trial. Lancet Oncol, 20(3): 352-360. [DOI:10.1016/S1470-2045(18)30813-1]
26. Kim DY, Park E, Heo CY, et al. (2021) Hypofractionated versus conventional fractionated radiotherapy for breast cancer in patients with reconstructed breast: Toxicity analysis. Breast, 55: 37-44. [DOI:10.1016/j.breast.2020.11.020]
27. Soonthornrak J, Amornwichet N, Shotelersuk K, et al. (2022) Toxicity and cosmetic outcome in hypofractionated radiation therapy for ductal carcinoma in situ after breast-conserving surgery: a preliminary report. International Journal of Radiation Research, 20(2): 383-387. [DOI:10.52547/ijrr.20.2.19]
28. Valle LF, Agarwal S, Bickel KE, et al. (2017) Hypofractionated whole breast radiotherapy in breast conservation for early-stage breast cancer: a systematic review and meta-analysis of randomized trials. Breast Cancer Res Treat, 162(3): 409-417. [DOI:10.1007/s10549-017-4118-7]
29. Reboucas LM, Campos CS, D'Amico GM, et al. (2019) Once-weekly hypofractionated radiotherapy for breast cancer: First results of a phase II clinical trial. Breast J, 25(5): 953-957. [DOI:10.1111/tbj.13372]
30. Hong Z, Yang Z, Mei X, et al. (2023) A retrospective study of adjuvant proton radiotherapy for breast cancer after lumpectomy: a comparison of conventional-dose and hypofractionated dose. Radiat Oncol, 18(1): 56. [DOI:10.1186/s13014-023-02213-8]
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Tang J, Xu X, Chen M, Liu L, Zhan Z. Efficacy and safety of hypofractionated radiotherapy and conventional fractionated radiotherapy in the treatment of early breast cancer patients after breast-conserving surgery. Int J Radiat Res 2025; 23 (1) :163-168
URL: http://ijrr.com/article-1-6000-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 23, Issue 1 (1-2025) Back to browse issues page
International Journal of Radiation Research
Persian site map - English site map - Created in 0.11 seconds with 48 queries by YEKTAWEB 4704