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Efficacy and safety of hypofractionated radiotherapy and conventional fractionated radiotherapy in the treatment of early breast cancer patients after breast-conserving surgery
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J. Tang   , X. Xu , M. Chen , L. Liu , Z. Zhan |
| Department of Oncology, Pingxiang People’s Hospital, Pingxiang, Jiangxi 337055, China , jiangxtjl350@163.com |
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Abstract: (191 Views) |
Background: To compare the efficacy as well as safety of hypofractionated radiotherapy (HFRT) with conventional fractionated radiotherapy (CFRT) for the treatment of early breast cancer (EBC) patients after breast-conserving surgery (BCS). Materials and Methods: Clinical data of 126 early breast cancer patients diagnosed and treated in our hospital from March 2021 to June 2023 were retrospectively analyzed. Patients were divided into HFRT group and CFRT group. The CFRT group accepted conventional segment radiotherapy. The HFRT group accepted hypofractionated radiotherapy. The clinical effect, breast beauty effect, incidence of adverse reactions, duration of hospital stay, local recurrence as well as distant metastasis in two groups were compared. Results: The HFRT and CFRT group showed no statistical difference in total response rate, breast beauty effect, length of hospital stay, local recurrence and distant metastasis rate (P>0.05). The incidence of bone marrow suppression, acute skin adverse reactions and radiation pneumonia in the HFRT group was lower than that in the CFRT group (P<0.05). The advanced skin adverse reactions were not statistically different between groups (P>0.05). Conclusion: Conventional radiotherapy and hypofractionated radiotherapy have similar clinical efficacy and safety for early breast cancer patients after BCS, while hypofractionated radiotherapy with the advantages of less radiotherapy times, short course of treatment and higher safety is valuable for clinical treatment. |
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| Keywords: Breast cancer, breast conserving surgery, hypofractionated radiotherapy. |
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Full-Text [PDF 588 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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