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A practical method of target volume delineation based on peritumoral edema in radiation therapy of glioblastoma
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H. Zhang   , S. Hao , T. Wu , Y. Xu , D. Yang , Y. Sun , P. Zhang , Y. Yan |
| Department of Radiation Oncology, General Hospital of Northern Theater Command, Shenyang, Liaoning Province, China , yanyingdoctor@sina.com |
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Abstract: (51 Views) |
Background: To introduce a simple glioblastoma (GBM) target delineation method based on peritumoral edema. Materials and Methods: A postoperative GBM patient was selected, the target volume was delineated using three methods, including the methods recommended by the Radiation Therapy Oncology Group (RTOG method), by the European Organization for Research and Treatment of Cancer (EORTC method) and by this study (New method), and radiotherapy plans were formulated by the same physicist. The dose distributions of each schedule were compared. Then, patients treated with the delineation method recommended in this study were retrospectively analyzed, and progression-free survival and overall survival were determined. Results: The distributions of the high-dose regions of the 3 plans were as follows: RTOG method > EORTC method > New method, as was the low-dose region. Thirty-three patients were included in this retrospective study, and the median progression-free survival (PFS) and overall survival (OS) were 12 and 25 months, respectively. Conclusions: Our study suggested that delineating the target volume for GBM radiotherapy based on peritumoral edema is a good choice. |
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| Keywords: Glioblastoma, Target volume, Delineating, Peritumoral edema. |
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Full-Text [PDF 964 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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