Department of Laboratory of Optoelectronics and Devices, Physics Department, Faculty of Sciences, UFAS1; Algeria , narimane.dahdouh@univ-setif.dz
Abstract: (10 Views)
Background: Our new present study uses biological indices to predict NTCP (normal tissue complications probability) and TCP (tumor control probability) in breast cancer patients undergoing mastectomy planned with MIT (monoisocentric technique) and DIT (dual isocentric technique) in the 3DCRT (three-dimensional conformal radiotherapy). Materials and Methods: This study involved using DVH (dose-volume histograms) from randomly selected patients to calculate the NTCP and TCP with our in-house program, RADBIOFOR. We focused on specific parameters related to pneumonitis in the lungs, pericarditis in the heart, and tumor control for the targeted area. Results: The incidence of clinical symptomatic pneumonitis grade 2 is lower for MIT than DIT, with a mean difference of 6.86%, 1.39% for symptomatic radiation pneumonitis grade 2, 1.17% and 0.82% for radiation pneumonitis grade 2. Both techniques produced comparable results, with MIT showing slightly better control than DIT, resulting in a mean difference of 0.18%. Our study suggests that the mean lung dose significantly affects the incidence of radiation pneumonitis. Conclusion: MIT outperforms DIT and offers better lung and heart protection with a lower incidence of radiation complications. Similar local control rates in the chest wall and lymph node region.
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